DRSC/TRiP Functional Genomics Resources

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Protein Alignment Con and LRRC4

DIOPT Version :9

Sequence 1:NP_001246635.1 Gene:Con / 38590 FlyBaseID:FBgn0005775 Length:691 Species:Drosophila melanogaster
Sequence 2:NP_071426.1 Gene:LRRC4 / 64101 HGNCID:15586 Length:653 Species:Homo sapiens


Alignment Length:309 Identity:76/309 - (24%)
Similarity:128/309 - (41%) Gaps:47/309 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   118 MCYCTPDENHVPVQKAECWVFSEGLHQNDTTWTRFYQQKRLRELKFVIQNNARLDYIPTMIIEPL 182
            :|.|:...:.|...:.......:|:..|    ||:..         :::||.::  |.......|
Human    49 VCSCSNQFSKVVCTRRGLSEVPQGIPSN----TRYLN---------LMENNIQM--IQADTFRHL 98

  Fly   183 KNLSSIVIEYSQVEIVKSYAFANLPFLERIILNNNHIMALDQDAFANHIRLRELNLEHNQIFEMD 247
            .:|..:.:..:.:..::..||..|..|..:.|.:|.:..:...||....:||||.|.:|.|..:.
Human    99 HHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPIESIP 163

  Fly   248 RYAFRNLPLCERLFLNN-NNISTLHEGLFADMARLTFLNLAHNQINVLTSEIFRGLGNLNVLKLT 311
            .|||..:|...||.|.. ..:..:.||.|..:..|.:|||              |:.|:..:.  
Human   164 SYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNL--------------GMCNIKDMP-- 212

  Fly   312 RNNLNFIGDTVFAELWSLSELELDDNRIERISERALDGLNTLKTLNLRNNLLKKIDNGLLRGTPA 376
              ||        ..|..|.|||:..|....|...:..||::||.|.:.|:.:..|:.....|..:
Human   213 --NL--------TPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLAS 267

  Fly   377 LLSINVQANKLETLTFYTFQPIMDNLVNSTSELLVSDNKFICDCRLQWI 425
            |:.:|:..|.|.:|....|.|:. .||    ||.:..|.:.|||.:.|:
Human   268 LVELNLAHNNLSSLPHDLFTPLR-YLV----ELHLHHNPWNCDCDILWL 311

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ConNP_001246635.1 LRR_RI <147..291 CDD:238064 36/144 (25%)
LRR_8 183..243 CDD:290566 15/59 (25%)
leucine-rich repeat 185..208 CDD:275380 4/22 (18%)
leucine-rich repeat 209..232 CDD:275380 5/22 (23%)
LRR_RI <225..416 CDD:238064 54/191 (28%)
LRR_8 232..291 CDD:290566 21/59 (36%)
leucine-rich repeat 233..256 CDD:275380 10/22 (45%)
leucine-rich repeat 257..280 CDD:275380 6/23 (26%)
leucine-rich repeat 281..304 CDD:275380 5/22 (23%)
LRR_8 304..363 CDD:290566 16/58 (28%)
leucine-rich repeat 305..328 CDD:275380 3/22 (14%)
leucine-rich repeat 329..352 CDD:275380 8/22 (36%)
LRR_8 352..416 CDD:290566 18/63 (29%)
leucine-rich repeat 353..376 CDD:275380 6/22 (27%)
LRRCT 414..>450 CDD:214507 5/12 (42%)
LRRC4NP_071426.1 LRRNT 46..79 CDD:214470 6/33 (18%)
LRR <74..291 CDD:227223 63/258 (24%)
LRR 1 76..97 6/35 (17%)
leucine-rich repeat 77..100 CDD:275380 6/33 (18%)
LRR 2 100..121 3/20 (15%)
leucine-rich repeat 101..124 CDD:275380 4/22 (18%)
LRR 3 124..145 5/20 (25%)
leucine-rich repeat 125..148 CDD:275380 5/22 (23%)
LRR 4 148..169 10/20 (50%)
leucine-rich repeat 149..172 CDD:275380 10/22 (45%)
LRR 5 172..194 6/21 (29%)
leucine-rich repeat 173..197 CDD:275380 6/23 (26%)
LRR 6 197..218 8/46 (17%)
leucine-rich repeat 198..219 CDD:275380 9/46 (20%)
LRR 7 219..240 6/20 (30%)
leucine-rich repeat 220..243 CDD:275380 8/22 (36%)
LRR 8 243..264 5/20 (25%)
leucine-rich repeat 244..267 CDD:275380 6/22 (27%)
LRR 9 267..288 6/20 (30%)
leucine-rich repeat 268..289 CDD:275380 6/20 (30%)
LRRCT 300..351 CDD:214507 5/12 (42%)
IG 359..441 CDD:214652
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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