DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Con and LGR6

DIOPT Version :9

Sequence 1:	NP_001246635.1	Gene:	Con / 38590	FlyBaseID:	FBgn0005775	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_001017403.1	Gene:	LGR6 / 59352	HGNCID:	19719	Length:	967	Species:	Homo sapiens

Alignment Length:	374	Identity:	100/374 - (26%)
Similarity:	158/374 - (42%)	Gaps:	66/374 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 CYCTPDENHVPVQKAECWVFSE-----------------GLHQNDTTWTR---FYQQKRLRELKF 163
            |:|..|.   .:..|:|   ||                 .|..|:.|..:   |:..:.|.||:.
Human    39 CHCQEDG---IMLSADC---SELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLRFLEELRL 97

  Fly   164 VIQNNARLDYIPTMIIEPLKNLSSIVIEYSQVEIVKSYAFANLPFLERIILNNNHIMALDQDAFA 228
               :...|.:||......|.:|..::::.:|:..:.:.|...||.|:.:.|:.|.|..:.:.:|.
Human    98 ---SGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFE 159

  Fly   229 NHIRLRELNLEHNQIFEMDRYAFRNLPLCERLFLNNNNISTLHEGLFADMARLTFLNLAHNQINV 293
            ....||.|.|:.|.:.|:...|..|||..:.:.|..|.||.:.:..|.::..|..|:|.:|:|..
Human   160 GLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQH 224

  Fly   294 LTSEIFRGLGNLNVLKLTRNNLNFIGDTVFAELWSLSELELDDNRIERISERALDGLNTLKTLNL 358
            |.:..|.||.||..|.|..|.|... ......|..|.||...:|.|:.|.|:|..|...|:|::.
Human   225 LGTHSFEGLHNLETLDLNYNKLQEF-PVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHF 288

  Fly   359 RNNLLKKIDNGLLRGTPAL--LSIN----VQ-------ANKLETLTFYTFQPIMDNLVNSTSELL 410
            .:|.::.:.....:..|.|  ||:|    :|       ...||.||          |..:...||
Human   289 YDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILT----------LTRAGIRLL 343

  Fly   411 VSDNKFICD--CRLQWIFELKNRTRHLQLRDSLEDLH-C-TLQEPKLSH 455
            .|.   :|.  .||: :.||.    |.|: :.|..|| | .|:|..|.|
Human   344 PSG---MCQQLPRLR-VLELS----HNQI-EELPSLHRCQKLEEIGLQH 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Con	NP_001246635.1	LRR_RI	<147..291	CDD:238064	38/146 (26%)
		LRR_8	183..243	CDD:290566	15/59 (25%)
		leucine-rich repeat	185..208	CDD:275380	4/22 (18%)
		leucine-rich repeat	209..232	CDD:275380	5/22 (23%)
		LRR_RI	<225..416	CDD:238064	58/203 (29%)
		LRR_8	232..291	CDD:290566	19/58 (33%)
		leucine-rich repeat	233..256	CDD:275380	9/22 (41%)
		leucine-rich repeat	257..280	CDD:275380	5/22 (23%)
		leucine-rich repeat	281..304	CDD:275380	9/22 (41%)
		LRR_8	304..363	CDD:290566	19/58 (33%)
		leucine-rich repeat	305..328	CDD:275380	6/22 (27%)
		leucine-rich repeat	329..352	CDD:275380	9/22 (41%)
		LRR_8	352..416	CDD:290566	17/76 (22%)
		leucine-rich repeat	353..376	CDD:275380	3/22 (14%)
		LRRCT	414..>450	CDD:214507	12/39 (31%)
LGR6	NP_001017403.1	LRRNT	34..68	CDD:214470	7/34 (21%)
		LRR_RI	<57..199	CDD:238064	33/144 (23%)
		leucine-rich repeat	70..91	CDD:275380	4/20 (20%)
		LRR 1	91..112		6/23 (26%)
		LRR_8	92..150	CDD:290566	15/60 (25%)
		leucine-rich repeat	92..115	CDD:275380	7/25 (28%)
		LRR 2	115..136		3/20 (15%)
		leucine-rich repeat	116..139	CDD:275380	4/22 (18%)
		LRR_RI	131..392	CDD:238064	80/273 (29%)
		LRR 3	139..160		5/20 (25%)
		leucine-rich repeat	140..163	CDD:275380	5/22 (23%)
		LRR 4	163..186		8/22 (36%)
		leucine-rich repeat	164..187	CDD:275380	9/22 (41%)
		LRR_8	186..246	CDD:290566	20/59 (34%)
		LRR 5	187..208		5/20 (25%)
		leucine-rich repeat	188..211	CDD:275380	5/22 (23%)
		LRR 6	211..232		7/20 (35%)
		leucine-rich repeat	212..235	CDD:275380	9/22 (41%)
		LRR 7	235..256		6/21 (29%)
		leucine-rich repeat	236..258	CDD:275380	6/22 (27%)
		LRR_8	258..314	CDD:290566	16/55 (29%)
		LRR 8	258..279		8/20 (40%)
		leucine-rich repeat	259..282	CDD:275380	9/22 (41%)
		LRR 9	282..303		3/20 (15%)
		leucine-rich repeat	283..304	CDD:275380	3/20 (15%)
		LRR 10	306..328		5/21 (24%)
		LRR 11	329..350		9/33 (27%)
		leucine-rich repeat	330..344	CDD:275378	6/23 (26%)
		LRR 12	353..374		9/26 (35%)
		leucine-rich repeat	354..399	CDD:275380	13/36 (36%)
		LRR_8	375..434	CDD:290566	4/9 (44%)
		LRR 13	375..396		4/9 (44%)
		leucine-rich repeat	376..390	CDD:275378	4/8 (50%)
		LRR 14	399..420
		leucine-rich repeat	400..423	CDD:275380
		LRR 15	423..443
		leucine-rich repeat	424..444	CDD:275380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141303
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840