DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Con and nyx

DIOPT Version :9

Sequence 1:	NP_001246635.1	Gene:	Con / 38590	FlyBaseID:	FBgn0005775	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_001071085.1	Gene:	nyx / 568821	ZFINID:	ZDB-GENE-061026-3	Length:	469	Species:	Danio rerio

Alignment Length:	414	Identity:	99/414 - (23%)
Similarity:	160/414 - (38%)	Gaps:	96/414 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 CTRRRDMKLMCYCTPDENHVPV----QKAECWVFSEGLHQNDTTWTRFYQQKRLRELKFVIQNNA 169
            ||:.:...::|      :||.:    ::..|...|..|.:|              .|||:.:.
Zfish    34 CTQEKSCSVLC------DHVNMMDLPKEFPCEASSINLDKN--------------SLKFLSER-- 76

  Fly   170 RLDYIPTMIIEPLKNLSSIVIEYSQVEIVKSYAFANLP-FLERIILNNNHIMALDQDAFANHIRL 233
                    ....|.:|.::.::|:.:..:...||..|| .:|..:.:|.:|..|....|....||
Zfish    77 --------AFGTLPSLKTLSLKYNNISFITPGAFKGLPNLVELKMAHNEYIRYLHTRTFTALKRL 133

  Fly   234 RELNLEHNQIFEM-DRYAFRNLPLCERLFLNNNNISTLHEGLFADMARLTFLNLAHNQINVLTSE 297
            ..|:|....:|.| ||.....:.|.|.|...||....  .|....|..||.:.|..|:|..:...
Zfish   134 VRLDLSDCNLFNMPDRIFLEQITLKELLCFQNNFRRV--PGALRGMENLTHVYLERNKIEAVAYN 196

  Fly   298 IFRGLGNLNVLKLTRNNLNFIGDTVFAELWSLSELELDDNRIERISERALDGLNTLKTLNLRNNL 362
            ...||.:|..|.|..|.:|.|.|..|.:|..|....|:||.:..:.::|..||:.||.|||..||
Zfish   197 SLLGLTSLKYLNLQENRINVIHDEAFKDLIRLENFYLNDNLLVDLPQQAFKGLSNLKMLNLGGNL 261

  Fly   363 LKK------------------------IDNGLLRGTPALLSINVQANKLETLTFYTFQPIMDNLV 403
            |..                        |::|......:|:::::.:|.|.:|.|..||||.
Zfish   262 LTNVSKTWFSDLVELEVLYLDRNRLSYIEDGSFENLTSLITLHLNSNNLTSLPFSVFQPIY---- 322

  Fly   404 NSTSELLVSDNKFICDCRLQWIFELKNRTRHLQLRDSLEDLHCT---------LQEPKLSHF--- 456
             ....|.:..|.:.|.|.|:|:.|      .::....:.|:.|.         |.|...:|.
Zfish   323 -FIGRLYLFRNPWECTCDLEWLRE------WMESYKLVRDIPCASPSSVAGLDLSEVVFAHLNST 380

  Fly   457 -VDP--------VP--PTILDVLN 469
             :||        :|  ||:.:..|
Zfish   381 CLDPPELNMTTSLPDYPTVENKFN 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Con	NP_001246635.1	LRR_RI	<147..291	CDD:238064	34/145 (23%)
		LRR_8	183..243	CDD:290566	15/60 (25%)
		leucine-rich repeat	185..208	CDD:275380	6/23 (26%)
		leucine-rich repeat	209..232	CDD:275380	5/22 (23%)
		LRR_RI	<225..416	CDD:238064	60/215 (28%)
		LRR_8	232..291	CDD:290566	19/59 (32%)
		leucine-rich repeat	233..256	CDD:275380	7/23 (30%)
		leucine-rich repeat	257..280	CDD:275380	6/22 (27%)
		leucine-rich repeat	281..304	CDD:275380	7/22 (32%)
		LRR_8	304..363	CDD:290566	22/58 (38%)
		leucine-rich repeat	305..328	CDD:275380	9/22 (41%)
		leucine-rich repeat	329..352	CDD:275380	7/22 (32%)
		LRR_8	352..416	CDD:290566	21/87 (24%)
		leucine-rich repeat	353..376	CDD:275380	10/46 (22%)
		LRRCT	414..>450	CDD:214507	9/44 (20%)
nyx	NP_001071085.1	leucine-rich repeat	64..83	CDD:275380	6/42 (14%)
		LRR_8	82..143	CDD:290566	15/60 (25%)
		leucine-rich repeat	84..107	CDD:275380	5/22 (23%)
		leucine-rich repeat	108..132	CDD:275380	5/23 (22%)
		LRR_RI	<127..311	CDD:238064	51/185 (28%)
		leucine-rich repeat	133..179	CDD:275380	14/47 (30%)
		LRR_8	179..238	CDD:290566	20/58 (34%)
		leucine-rich repeat	180..203	CDD:275380	7/22 (32%)
		leucine-rich repeat	204..227	CDD:275380	9/22 (41%)
		LRR_8	227..286	CDD:290566	15/58 (26%)
		leucine-rich repeat	228..251	CDD:275380	7/22 (32%)
		leucine-rich repeat	252..275	CDD:275380	8/22 (36%)
		LRR_8	275..333	CDD:290566	12/62 (19%)
		leucine-rich repeat	276..299	CDD:275380	2/22 (9%)
		leucine-rich repeat	300..319	CDD:275380	5/18 (28%)
		LRRCT	332..>366	CDD:214507	8/39 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D277227at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010