DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Con and lrrc24

DIOPT Version :9

Sequence 1:	NP_001246635.1	Gene:	Con / 38590	FlyBaseID:	FBgn0005775	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	XP_009297158.1	Gene:	lrrc24 / 565790	ZFINID:	ZDB-GENE-060503-496	Length:	692	Species:	Danio rerio

Alignment Length:	495	Identity:	115/495 - (23%)
Similarity:	197/495 - (39%)	Gaps:	133/495 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   238 LEHNQIFEMDRYAFRNLPLCERLFLNNNNISTLHEGLFADMARLTFLNLAHNQINVLTSEIFRGL 302
            |:.|.|.::.:....:|.....|:|.||:||||..|.|..:..|..|.|..|:|:::|:::||||
Zfish   156 LQDNAIGQIRQRDLSDLGQLHYLYLQNNSISTLEPGAFRSLGLLLELALNGNRIHLITADVFRGL 220

  Fly   303 GNLNVLKLTRNNLNFIGDTVFAELWSLSELELDDNRIERISERALDGLNTLKTLNL-RNNLLKKI 366
            .:|.:|.|..|.:|.:.|..|..|..|.||.|.:|.:|.:.::||.||::|..|:| |||
Zfish   221 DHLRILYLAGNQINRLEDYTFRGLQRLQELHLQENVLEVLGDQALVGLSSLALLDLSRNN----- 280

  Fly   367 DNGLLRGTPALLSINVQANKLETLTFYTFQPIMDNLVNSTSELLVSDNKFICDCRLQWIFELKNR 431
                                |.||:..:.:|::     |...|.|:||.:.|||.|.|:....|.
Zfish   281 --------------------LRTLSPASLKPLV-----SLQVLRVTDNPWRCDCALHWLRGWINE 320

  Fly   432 TRHLQLRDSLEDLHCTLQEPKLSHF----VDP-----VPPTILDVLNIGGFTAIGSNSASMGGVG 487
            .....|..:...:.|. :.|:|||.    |.|     :||.:
Zfish   321 EGQRLLSSAERRMLCA-EPPRLSHLSLVEVPPNSLVCIPPVV----------------------- 361

  Fly   488 NSVVGSSYSGLTMDDSRKHLGSRSRQALRGQRQFASSAENVV--------ESKMRRRRKRQEEVK 544
                       .::.|  ||..|..::||...|.:...:..|        ::::..|...||...
Zfish   362 -----------QLEPS--HLTVRLGESLRVSCQASGYPQPQVTWRKASHGKAQLSPRGLVQEVGM 413

  Fly   545 EKD------LAAVAPAHK------------RYDYYDDNNGGMSLGHGLDLDDNLSLHKQGFY--- 588
            :.|      |....|..|            ..|..|..|.....|.|:....|:::...|.|
Zfish   414 DGDTRNGGRLVTARPGGKGGPSSHGPIRGGADDGADRENFDPDTGSGMLFLSNVTVAHAGRYECE 478

  Fly   589 ----GAGSPVVGHNDVDVLMTSHSASGDALDILTTKNAIYIKLFLLKPEMLPCHDELSDPTELPL 649
                |..:.|..|  :.|.|:|.|:..:....|.:.:..:                   |:.:.:
Zfish   479 AWNPGGVARVTFH--LSVNMSSSSSRSEIWPRLHSSSYYH-------------------PSSVDV 522

  Fly   650 SRD-LMDVRSNVGQDMSTAGANSLAQGMTIIVSLVALMMI 688
            |:: |.::.|.....:.||...::|.|:::: :|.||:::
Zfish   523 SQEPLYELESMDFNALGTATQTAIAVGISLL-ALTALLLL 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Con	NP_001246635.1	LRR_RI	<147..291	CDD:238064	18/52 (35%)
		LRR_8	183..243	CDD:290566	2/4 (50%)
		leucine-rich repeat	185..208	CDD:275380
		leucine-rich repeat	209..232	CDD:275380
		LRR_RI	<225..416	CDD:238064	57/178 (32%)
		LRR_8	232..291	CDD:290566	18/52 (35%)
		leucine-rich repeat	233..256	CDD:275380	4/17 (24%)
		leucine-rich repeat	257..280	CDD:275380	10/22 (45%)
		leucine-rich repeat	281..304	CDD:275380	10/22 (45%)
		LRR_8	304..363	CDD:290566	24/59 (41%)
		leucine-rich repeat	305..328	CDD:275380	8/22 (36%)
		leucine-rich repeat	329..352	CDD:275380	10/22 (45%)
		LRR_8	352..416	CDD:290566	15/64 (23%)
		leucine-rich repeat	353..376	CDD:275380	6/23 (26%)
		LRRCT	414..>450	CDD:214507	9/35 (26%)
lrrc24	XP_009297158.1	leucine-rich repeat	151..174	CDD:275378	4/17 (24%)
		LRR_8	174..257	CDD:290566	33/82 (40%)
		LRR_4	174..238	CDD:289563	25/63 (40%)
		leucine-rich repeat	175..222	CDD:275378	20/46 (43%)
		leucine-rich repeat	199..218	CDD:275380	6/18 (33%)
		LRR_8	222..304	CDD:290566	32/111 (29%)
		LRR_4	222..258	CDD:289563	13/35 (37%)
		leucine-rich repeat	223..246	CDD:275378	8/22 (36%)
		leucine-rich repeat	247..294	CDD:275378	20/76 (26%)
		leucine-rich repeat	295..307	CDD:275378	4/11 (36%)
		LRRCT	303..356	CDD:214507	15/53 (28%)
		IG_like	365..494	CDD:214653	26/132 (20%)
		Ig	376..491	CDD:143165	21/114 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574233
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930