DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Con and lrig3

DIOPT Version :9

Sequence 1:	NP_001246635.1	Gene:	Con / 38590	FlyBaseID:	FBgn0005775	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_001103817.1	Gene:	lrig3 / 564554	ZFINID:	ZDB-GENE-130530-866	Length:	1070	Species:	Danio rerio

Alignment Length:	751	Identity:	152/751 - (20%)
Similarity:	258/751 - (34%)	Gaps:	247/751 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 SGSTGYSGPMDSTGFCTRRRDMKLMCYCTPDENHVPVQKAECWVFSEGLHQNDTTWTRFYQQKRL 158
            ||.|..:|  ||..  |.......:|.||.:       .|:|.....|         |..::...
Zfish    18 SGFTAVTG--DSRR--TEHEPCPSVCSCTGN-------LADCSRLKAG---------RTVERLPA 62

  Fly   159 RELKFVIQNNARLDYIPTMIIEPLKNLSSIVIEYSQVEIVKSYAFANLPFLERIILNNNHIMALD 223
            |..:..:.:| :|...|..:...|..||.|.:..::.|.:.... .|...|..:||.:|.|..:.
Zfish    63 RITRLDLSHN-KLRVFPEALFSSLPQLSEIKLSNNEFESIPDLG-PNAGNLSSLILASNRIGRVS 125

  Fly   224 QDAFANHIRLRELNLEHNQIFEMDRYAFRNLPLCERLFLNNNNISTLHEGLFADM-ARLTFLNLA 287
            .:..:..:.|..|:|.:|.|.::...||..:|| :.||:|||.||||..|.|::: :.|..|.|.
Zfish   126 SERLSPLLTLETLDLSNNNIVDVYAGAFPPIPL-KNLFMNNNRISTLEHGCFSNLSSSLLVLKLN 189

  Fly   288 HNQINVLTSEIFR-----------------------------------------------GLGNL 305
            .|::|.:.::||.                                               ||.|:
Zfish   190 KNRLNSIPAKIFSLPHLQHLELSRNRLRRVEGLTFQGLHGLRSLKMQRNGISRLMDGAFWGLNNM 254

  Fly   306 NVLKLTRNNLNFIG--------------------DTVFAELW----SLSELELDDNRIERISERA 346
            .||:|..|||..:.                    ..:..:.|    .|:||:|..|::.|:.|.:
Zfish   255 EVLQLEFNNLTEVSKGWLYGLLTLQQLHLSHNSISRIKPDAWEFCQKLAELDLSWNQLSRLEEGS 319

  Fly   347 LDGLNTLKTLNLRNNLLKKIDNGLLRGTPALLSIN---------------------------VQA 384
            ..||:.|:.|::.||.:..|.:|..||...|.:::                           :|.
Zfish   320 FVGLSVLEQLHIGNNRISFIADGAFRGLTNLQTLDLKFNEISWTIEDMNGPFSALDNLRKLFLQG 384

  Fly   385 NKLETLTFYTF-------------QPIMDNLVNS------TSELLVSDNKFICDCRLQWIFELKN 430
            |::.::|..:|             ..||....|:      .|||.::.:..:|||:|:|.
Zfish   385 NRIRSVTRKSFTGLEMLEQLDLSNNAIMSLQANAFSQMKKLSELHLNTSSLLCDCQLKWF----- 444

  Fly   431 RTRHLQLRDSL---EDLHCTLQEPKLSHFVDPVPPTILDVLNIGGFTAIGSNSASMGGVGNSVVG 492
                     ||   |.....|.....:|      |.:|.                    |.||..
Zfish   445 ---------SLWVAEQAFLALLNASCAH------PHLLK--------------------GRSVFS 474

  Fly   493 SSYSGLTMDDSRK---HLGSRSRQALRGQR-QFASSAENVVESKMRRRRKRQEE-VKEKDLAAVA 552
            .:......||..|   .:...::.|::|.. .|..||.:..:|.|....|:..| :.|.::.  .
Zfish   475 IAQDEFVCDDFPKPQITVQPETQSAIKGNNVTFVCSAASSSDSPMTFAWKKDNELLSEPEIQ--N 537

  Fly   553 PAHKRYDYYDDNNGGMSLGHGLDLDDNLSLHKQGFYGAGSPVVGHNDVDVLMTSHSASGDALDIL 617
            .||.|       ......|...:....|.|.:..|...|.       ...::::|..|..:....
Zfish   538 QAHVR-------AAAGETGELTEYTTTLQLRQVEFTSEGR-------YQCVISNHFGSSYSNKAK 588

  Fly   618 TTKNAIYIKLFLLKPEM-----------LPC----HD------ELSDPTELPLSRD--------- 652
            .|.|.:   .|..|..|           |.|    |.      :....|:.|.:|:
Zfish   589 LTVNML---PFFTKTPMDLTIRAGATARLECAASGHPSPQIAWQKDGGTDFPAARERRMHVMPRD 650

  Fly   653 ----LMDVRS-NVG----QDMSTAGANSLAQGMTII 679
                ::||:: ::|    ...:||||.|....:|::
Zfish   651 DVFFIVDVKTEDIGVYSCTAQNTAGAISANATLTVL 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Con	NP_001246635.1	LRR_RI	<147..291	CDD:238064	40/144 (28%)
		LRR_8	183..243	CDD:290566	14/59 (24%)
		leucine-rich repeat	185..208	CDD:275380	5/22 (23%)
		leucine-rich repeat	209..232	CDD:275380	5/22 (23%)
		LRR_RI	<225..416	CDD:238064	65/308 (21%)
		LRR_8	232..291	CDD:290566	24/59 (41%)
		leucine-rich repeat	233..256	CDD:275380	7/22 (32%)
		leucine-rich repeat	257..280	CDD:275380	11/23 (48%)
		leucine-rich repeat	281..304	CDD:275380	9/69 (13%)
		LRR_8	304..363	CDD:290566	21/82 (26%)
		leucine-rich repeat	305..328	CDD:275380	7/46 (15%)
		leucine-rich repeat	329..352	CDD:275380	9/22 (41%)
		LRR_8	352..416	CDD:290566	19/109 (17%)
		leucine-rich repeat	353..376	CDD:275380	8/22 (36%)
		LRRCT	414..>450	CDD:214507	9/38 (24%)
lrig3	NP_001103817.1	LRR_RI	<62..330	CDD:238064	62/270 (23%)
		LRR_8	63..121	CDD:290566	14/59 (24%)
		leucine-rich repeat	64..87	CDD:275378	4/23 (17%)
		leucine-rich repeat	88..110	CDD:275378	5/22 (23%)
		LRR_8	110..168	CDD:290566	19/58 (33%)
		leucine-rich repeat	111..134	CDD:275380	5/22 (23%)
		leucine-rich repeat	135..156	CDD:275380	7/20 (35%)
		leucine-rich repeat	158..205	CDD:275380	19/47 (40%)
		LRR_8	204..264	CDD:290566	7/59 (12%)
		leucine-rich repeat	206..229	CDD:275380	0/22 (0%)
		leucine-rich repeat	230..253	CDD:275380	2/22 (9%)
		LRR_RI	251..>435	CDD:238064	37/183 (20%)
		LRR_8	253..312	CDD:290566	13/58 (22%)
		leucine-rich repeat	254..277	CDD:275380	6/22 (27%)
		leucine-rich repeat	278..301	CDD:275380	1/22 (5%)
		LRR_8	301..360	CDD:290566	18/58 (31%)
		leucine-rich repeat	302..325	CDD:275380	9/22 (41%)
		leucine-rich repeat	326..349	CDD:275380	8/22 (36%)
		LRR_8	376..431	CDD:290566	10/54 (19%)
		leucine-rich repeat	377..400	CDD:275380	4/22 (18%)
		leucine-rich repeat	401..422	CDD:275380	3/20 (15%)
		TPKR_C2	435..483	CDD:301599	15/87 (17%)
		I-set	488..591	CDD:254352	20/118 (17%)
		Ig	505..581	CDD:143165	17/91 (19%)
		I-set	595..685	CDD:254352	17/89 (19%)
		Ig_1	612..686	CDD:143240	15/73 (21%)
		I-set	689..776	CDD:254352
		IGc2	703..766	CDD:197706
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574232
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840