DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Con and zgc:153913

DIOPT Version :9

Sequence 1:	NP_001246635.1	Gene:	Con / 38590	FlyBaseID:	FBgn0005775	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_001073448.1	Gene:	zgc:153913 / 559700	ZFINID:	ZDB-GENE-061103-397	Length:	496	Species:	Danio rerio

Alignment Length:	399	Identity:	99/399 - (24%)
Similarity:	174/399 - (43%)	Gaps:	52/399 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 FTSSSAVNSGSTGYSGPMDSTGFCTRRRDMKLMCYCTPD---ENHVPVQKAECWVFSEGLHQNDT 147
            |:.|..|.|.....|.|::   ..|:.|::.::....||   ::.....:....||..|:.:: .
Zfish    28 FSGSKLVCSDDRMKSLPVN---ISTQVRELIVVASGIPDLDQQSFPETLRLSKLVFLNGMLKS-V 88

  Fly   148 TWTRFYQQKRLRELKFVIQNNARLDYIPTMIIEPLKNLSSIVIEYSQVEIVKSYAFANLPFLERI 212
            :...|.:...||||:  |..|.....:.......|.||:.:::..:::..|.:..|.:|..||.:
Zfish    89 SGEAFERLVELRELE--ISGNICWMSLDIQTFSSLTNLTRLLLNNNKLSGVDAGLFHSLHQLEML 151

  Fly   213 ILNNNHIMALDQDAFANHIRLRELNLEHNQIFEMDRYAFRNLPLCERLFLNNNNISTLHEGLFAD 277
            .|..|.:..|....|....||:||:|..|||..:....|:|......|.|..|.|..|.:|:|..
Zfish   152 QLRGNGLSFLSGRLFQRLHRLQELDLSFNQISSLSTELFQNNSELRVLSLQANKIPNLPDGIFTH 216

  Fly   278 MARLTFLNLAHNQINV----------------------LTSEIFRGLGNLNVLKLTRNNLNFIGD 320
            :..|..|||..|.|.|                      ||:.:|..|..:..|.|::|:|..:..
Zfish   217 LDHLQELNLRSNLIRVLTPGSFPASLKTLILKKNLLEKLTNAVFHTLHYITYLDLSQNSLTEVPA 281

  Fly   321 TVFAELWSLSELELDDNRIERISERALDGLNTLKTLNLRNNLLKKIDNGLLRGTPALLSINVQAN 385
            .:|..|.||..|:|.:|||..::.....||.::|::.|:.|.|..:|..||:....|..:::..|
Zfish   282 DLFQNLISLETLDLSENRISTLAGSVFKGLFSIKSVYLQKNSLISVDAHLLKDQHDLQLLDLSNN 346

  Fly   386 KLETLT--FY---TFQPIMDNLVNSTSELLVSDNKFICDCRLQWIFE-LKNRTRHLQLRDSLEDL 444
            .|.::.  |:   .||.:.:          :..|.:.|||.:.:.:: ||...:|::   .|..:
Zfish   347 SLRSIPSGFFEDLDFQCVFE----------LRGNPWSCDCGIHYFYDWLKYNHKHVK---DLSRV 398

  Fly   445 HCTLQEPKL 453
            .|  :.|:|
Zfish   399 SC--EAPEL 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Con	NP_001246635.1	LRR_RI	<147..291	CDD:238064	41/143 (29%)
		LRR_8	183..243	CDD:290566	17/59 (29%)
		leucine-rich repeat	185..208	CDD:275380	4/22 (18%)
		leucine-rich repeat	209..232	CDD:275380	6/22 (27%)
		LRR_RI	<225..416	CDD:238064	58/217 (27%)
		LRR_8	232..291	CDD:290566	22/58 (38%)
		leucine-rich repeat	233..256	CDD:275380	9/22 (41%)
		leucine-rich repeat	257..280	CDD:275380	7/22 (32%)
		leucine-rich repeat	281..304	CDD:275380	11/44 (25%)
		LRR_8	304..363	CDD:290566	18/58 (31%)
		leucine-rich repeat	305..328	CDD:275380	6/22 (27%)
		leucine-rich repeat	329..352	CDD:275380	8/22 (36%)
		LRR_8	352..416	CDD:290566	14/68 (21%)
		leucine-rich repeat	353..376	CDD:275380	7/22 (32%)
		LRRCT	414..>450	CDD:214507	9/36 (25%)
zgc:153913	NP_001073448.1	leucine-rich repeat	75..98	CDD:275380	4/23 (17%)
		LRR_RI	141..>350	CDD:238064	61/208 (29%)
		LRR_8	147..206	CDD:290566	19/58 (33%)
		leucine-rich repeat	148..171	CDD:275380	6/22 (27%)
		leucine-rich repeat	172..195	CDD:275380	9/22 (41%)
		LRR_8	194..252	CDD:290566	14/57 (25%)
		leucine-rich repeat	196..219	CDD:275380	7/22 (32%)
		leucine-rich repeat	220..241	CDD:275380	7/20 (35%)
		leucine-rich repeat	242..265	CDD:275380	4/22 (18%)
		leucine-rich repeat	266..289	CDD:275380	6/22 (27%)
		LRR_8	267..324	CDD:290566	18/56 (32%)
		leucine-rich repeat	290..313	CDD:275380	8/22 (36%)
		leucine-rich repeat	314..337	CDD:275380	7/22 (32%)
		leucine-rich repeat	338..359	CDD:275380	4/20 (20%)
		TPKR_C2	370..>404	CDD:301599	9/38 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000