DRSC/TRiP Functional Genomics Resources

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Protein Alignment Con and lrit1a

DIOPT Version :10

Sequence 1:NP_523930.3 Gene:Con / 38590 FlyBaseID:FBgn0005775 Length:691 Species:Drosophila melanogaster
Sequence 2:NP_001018174.2 Gene:lrit1a / 553943 ZFINID:ZDB-GENE-040924-5 Length:643 Species:Danio rerio


Alignment Length:419 Identity:90/419 - (21%)
Similarity:159/419 - (37%) Gaps:110/419 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   263 NNNNISTLHEGLFADMARLTFLNLAHNQINVLTSEIFRGLGNLNVLKLTRNNLNFIGDTVFAELW 327
            |:..||.:......|.::   |.:....|..:.||.|..|.||..|.::.|.|:.:....|..|:
Zfish    46 NDPEISLVPASFPGDTSK---LRIEKTAIKRIPSEAFSYLSNLEFLWMSFNVLSSLNSDSFRGLY 107

  Fly   328 SLSELELDDNRIERISERALDGLNTLKTLNLRNNLLKKIDNGLLRGTPALLSINVQANKLETL-- 390
            ||.||.||.|.:......:|..:.:|:.|::.||.|..:.:........:..:::.:|.|.|:  
Zfish   108 SLEELRLDGNSLSSFPWESLMDMPSLRLLDIHNNQLSSLPSEAALYMKNITYLDLSSNNLLTVPA 172

  Fly   391 ----TFYTFQPIMDNLVNSTSELLVS--DNKFICDCRLQWIFELKNRTRHLQLRDSLED--LHCT 447
                |:.|.:|   .|...:|:|::.  ||.::|||||   ::|....:...|..:..|  |.|.
Zfish   173 EVLNTWLTIKP---TLGAESSKLILGLHDNPWLCDCRL---YDLVQFQKSPSLSVAFIDTRLRCA 231

  Fly   448 ---------LQEPKLSHFVDPVPPTILDVLNIGGFTAIGSN-SASMGGVG--------------- 487
                     ..:.:|.....|...|.:..:.    :|:|:| ....|.||               
Zfish   232 DPESLSGVLFSDAELRRCQGPRVHTAVARVR----SAVGNNVLLRCGTVGVPIPELAWRRADGKP 292

  Fly   488 --------NSVVGSSYSGLTMD-----DSRKHLGSRSRQALRGQRQFASSAENVV---------- 529
                    ||..|..:|.|::.     |:.|::...:        .:|.|||.|:          
Zfish   293 LNGTVLLENSKEGIVWSILSVPAVSYRDTGKYICKAT--------NYAGSAEAVISLIINDAPKM 349

  Fly   530 -----ESKMRRRRKRQEEV-----KEKDLAA-VAPAHKRYDYYDDNNGGMSLGHGLDLDDNLSLH 583
                 :.|.:.:.|:...:     :||.:|. |:|..|               :||.|...:|  
Zfish   350 ENPTLDPKPKLKSKKPNTMVKAAYQEKHIATYVSPTPK---------------NGLPLSGTVS-- 397

  Fly   584 KQGFYGAGSPVVGHNDVDVLMTSHSASGD 612
               :.|....:...|..:..|.:.:||.|
Zfish   398 ---YTGPYPGMESDNAANSRMNTQTASPD 423

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ConNP_523930.3 LRR <157..459 CDD:443914 52/214 (24%)
leucine-rich repeat 185..208 CDD:275380
leucine-rich repeat 209..232 CDD:275380
leucine-rich repeat 233..256 CDD:275380
leucine-rich repeat 257..280 CDD:275380 4/16 (25%)
leucine-rich repeat 281..304 CDD:275380 6/22 (27%)
leucine-rich repeat 305..328 CDD:275380 6/22 (27%)
leucine-rich repeat 329..352 CDD:275380 7/22 (32%)
leucine-rich repeat 353..376 CDD:275380 5/22 (23%)
lrit1aNP_001018174.2 LRR <49..>199 CDD:443914 38/155 (25%)
leucine-rich repeat 61..84 CDD:275378 6/25 (24%)
leucine-rich repeat 85..108 CDD:275378 6/22 (27%)
leucine-rich repeat 109..132 CDD:275378 7/22 (32%)
leucine-rich repeat 133..156 CDD:275378 5/22 (23%)
leucine-rich repeat 157..170 CDD:275378 2/12 (17%)
LRRCT 199..243 CDD:214507 11/46 (24%)
Ig 259..333 CDD:472250 13/85 (15%)
Ig strand B 269..273 CDD:409353 0/3 (0%)
Ig strand C 282..286 CDD:409353 0/3 (0%)
Ig strand E 309..313 CDD:409353 2/3 (67%)
Ig strand F 323..328 CDD:409353 1/4 (25%)
fn3 448..515 CDD:394996
Blue background indicates that the domain is not in the aligned region.

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