DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Con and LGR4

DIOPT Version :9

Sequence 1:	NP_001246635.1	Gene:	Con / 38590	FlyBaseID:	FBgn0005775	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_060960.2	Gene:	LGR4 / 55366	HGNCID:	13299	Length:	951	Species:	Homo sapiens

Alignment Length:	566	Identity:	137/566 - (24%)
Similarity:	213/566 - (37%)	Gaps:	114/566 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 GSTGYSGPMDSTGFCTRRRDMKLMCYCTPDENHVPVQKAEC-----WVFSEGL---------HQN 145
            ||.|.||.  :...|.      ..|.|..|      ::.:|     ....|||         ..|
Human    17 GSAGPSGA--APPLCA------APCSCDGD------RRVDCSGKGLTAVPEGLSAFTQALDISMN 67

  Fly   146 DTTW---TRFYQQKRLRELKFVIQNNARLDYIPTMIIEPLKNLSSIVIEYSQVEIVKSYAFANLP 207
            :.|.   ..|.....|.||:....:   |.:|....:..||.|..:.::.:|::.|.|.|...|.
Human    68 NITQLPEDAFKNFPFLEELQLAGND---LSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLS 129

  Fly   208 FLERIILNNNHIMALDQDAFANHIRLRELNLEHNQIFEMDRYAFRNLPLCERLFLNNNNISTLHE 272
            .|:.:.|:.|||.::.:|:|...::||.|.|:.|.:.|:..:...|||..:.|.|..|.||::.:
Human   130 ALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPD 194

  Fly   273 GLFADMARLTFLNLAHNQINVLTSEIFRGLGNLNVLKLTRNNLNFIGDTVFAELWSLSELELDDN 337
            ..|.:::.|..|:|.:|:|..|:...|.||.||..|.|..|||......:.| |.||.||....|
Human   195 FAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFPQAIKA-LPSLKELGFHSN 258

  Fly   338 RIERISERALDGLNTLKTLNLRNNLLKKIDNGLLRGTPALLSINVQANK-------------LET 389
            .|..|.:.|.||...|:|::|.:|.|..:.|........|.|:.::...             ||:
Human   259 SISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLES 323

  Fly   390 LTFYTFQPIMDNLVNSTSELLVSDNKFICDCRLQWIFELKNRTRHLQLRDSLEDLHCTLQEPKLS 454
            ||      :....::|....|..:.|.:....|.:     |..|.|   .|....| .|:|..|.
Human   324 LT------LTGTKISSIPNNLCQEQKMLRTLDLSY-----NNIRDL---PSFNGCH-ALEEISLQ 373

  Fly   455 H----------FVDPVPPTILDVLNIGGFTAIGSNS-ASMGGVGNSVVGSSYSGLTMDDSRKHLG 508
            .          |...:...||| |:......|.|.: |::|.:.|           :|.|...|.
Human   374 RNQIYQIKEGTFQGLISLRILD-LSRNLIHEIHSRAFATLGPITN-----------LDVSFNELT 426

  Fly   509 SRSRQALRGQRQFASSAENVVESKMRRRRKRQEEVKEKDLAAVAPAHKRYDYYDDNNGGMSLGHG 573
            |...:.|.|..|.          |:....|.:|.:..||...:......|.|......|......
Human   427 SFPTEGLNGLNQL----------KLVGNFKLKEALAAKDFVNLRSLSVPYAYQCCAFWGCDSYAN 481

  Fly   574 LDLDDNLSLHKQGFYGAGSPVVGHNDVDVLMTSHSASGDALDILTT 619
            |:.:|| ||.                 |..:.....:.||.::.:|
Human   482 LNTEDN-SLQ-----------------DHSVAQEKGTADAANVTST 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Con	NP_001246635.1	LRR_RI	<147..291	CDD:238064	41/146 (28%)
		LRR_8	183..243	CDD:290566	19/59 (32%)
		leucine-rich repeat	185..208	CDD:275380	6/22 (27%)
		leucine-rich repeat	209..232	CDD:275380	7/22 (32%)
		LRR_RI	<225..416	CDD:238064	59/203 (29%)
		LRR_8	232..291	CDD:290566	19/58 (33%)
		leucine-rich repeat	233..256	CDD:275380	8/22 (36%)
		leucine-rich repeat	257..280	CDD:275380	6/22 (27%)
		leucine-rich repeat	281..304	CDD:275380	9/22 (41%)
		LRR_8	304..363	CDD:290566	23/58 (40%)
		leucine-rich repeat	305..328	CDD:275380	8/22 (36%)
		leucine-rich repeat	329..352	CDD:275380	9/22 (41%)
		LRR_8	352..416	CDD:290566	14/76 (18%)
		leucine-rich repeat	353..376	CDD:275380	6/22 (27%)
		LRRCT	414..>450	CDD:214507	8/35 (23%)
LGR4	NP_060960.2	LRRNT	29..56	CDD:279764	7/38 (18%)
		LRR_RI	<44..239	CDD:238064	57/197 (29%)
		LRR 1	58..79		3/20 (15%)
		leucine-rich repeat	59..82	CDD:275380	3/22 (14%)
		LRR 2	82..103		5/23 (22%)
		LRR_8	83..141	CDD:290566	16/60 (27%)
		leucine-rich repeat	83..106	CDD:275380	6/25 (24%)
		LRR 3	106..127		5/20 (25%)
		leucine-rich repeat	107..130	CDD:275380	6/22 (27%)
		LRR 4	130..151		7/20 (35%)
		LRR_8	131..189	CDD:290566	19/57 (33%)
		leucine-rich repeat	131..154	CDD:275380	7/22 (32%)
		LRR 5	154..177		7/22 (32%)
		leucine-rich repeat	155..178	CDD:275380	8/22 (36%)
		LRR_8	177..237	CDD:290566	21/59 (36%)
		LRR 6	178..199		6/20 (30%)
		leucine-rich repeat	179..202	CDD:275380	6/22 (27%)
		LRR 7	202..223		7/20 (35%)
		leucine-rich repeat	203..226	CDD:275380	9/22 (41%)
		LRR_RI	221..426	CDD:238064	58/232 (25%)
		LRR 8	226..247		8/21 (38%)
		leucine-rich repeat	227..249	CDD:275380	8/22 (36%)
		LRR_8	248..305	CDD:290566	18/56 (32%)
		LRR 9	249..270		8/20 (40%)
		leucine-rich repeat	250..273	CDD:275380	9/22 (41%)
		LRR 10	273..294		6/20 (30%)
		leucine-rich repeat	274..295	CDD:275380	6/20 (30%)
		LRR 11	320..341		6/26 (23%)
		LRR 12	344..365		5/28 (18%)
		LRR_8	345..401	CDD:290566	14/65 (22%)
		leucine-rich repeat	345..366	CDD:275380	6/29 (21%)
		LRR 13	366..387		4/20 (20%)
		leucine-rich repeat	367..390	CDD:275380	4/22 (18%)
		LRR_8	390..444	CDD:290566	17/75 (23%)
		LRR 14	390..411		6/21 (29%)
		leucine-rich repeat	391..414	CDD:275380	7/23 (30%)
		LRR 15	414..435		6/31 (19%)
		leucine-rich repeat	415..438	CDD:275380	7/33 (21%)
		leucine-rich repeat	439..461	CDD:275380	5/31 (16%)
		7tm_1	556..801	CDD:278431
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141317
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840