DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Con and Lrit3

DIOPT Version :9

Sequence 1:	NP_001246635.1	Gene:	Con / 38590	FlyBaseID:	FBgn0005775	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	XP_006232069.1	Gene:	Lrit3 / 502596	RGDID:	1559637	Length:	702	Species:	Rattus norvegicus

Alignment Length:	334	Identity:	76/334 - (22%)
Similarity:	124/334 - (37%)	Gaps:	94/334 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   256 LCERLFLNNNNISTLHEGLFADMARLTFLNLAHNQINVLTSEIFRGLGNLNVLKLTRNNLNFIGD 320
            ||..|.:|.     :...|..|.|:   |.:....:..:.:|.|..|..|..|.||.|::..|..
  Rat    42 LCNDLDMNE-----VPTNLPVDTAK---LRIEKTVVRRIPAEAFYYLVELQYLWLTYNSVASIET 98

  Fly   321 TVFAELWSLSELELDDNRIERISERALDGLNTLKTLNLRNNLLKKIDNGLLRGTPALLSINVQAN 385
            ..|..|..|.||.||.|.:......:|..:..|:||:|.||.:..:.|..:|....|..:::.:|
  Rat    99 RSFYNLKQLHELRLDGNSLTEFPWASLLDMPHLRTLDLHNNRITSVTNEAVRYLRNLTCLDLSSN 163

  Fly   386 KLETLTFYTFQPIMDNLVNSTSELLVS-----------------DNKFICDCRLQWIFELKNRTR 433
            :|.||.        .:.::|.|.|.::                 ||.:.|||.:..:.||.....
  Rat   164 RLTTLP--------PDFLDSWSHLAMTPSRSPDLPPKRIILGLQDNPWFCDCHISKVIELSKVAD 220

  Fly   434 HLQLRDSLEDLHCTLQEPKLSHFVDPV------------PPTILDVLNIGGFTAIGSN------- 479
            |..:   |.|......||:   ::..:            |..::....|  .:|:|||
  Rat   221 HAAV---LLDPLMVCSEPE---YLQGIAFQRVELEKCLKPSVMMSATKI--TSALGSNVLLRCDA 277

  Fly   480 -----------------------SASMG-GVGNSVVGSSYSGLTMDDSRKHLGSRSRQALRGQRQ 520
                                   ..|.| ||..|::  |.:|:|..|:    |..|.:|    :.
  Rat   278 KGYPTPQLMWTRSDSSPVNATVIQESPGEGVRWSIL--SLTGITYRDA----GDYSCKA----KN 332

  Fly   521 FASSAENVV 529
            .|.::|.||
  Rat   333 LAGTSEAVV 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Con	NP_001246635.1	LRR_RI	<147..291	CDD:238064	8/34 (24%)
		LRR_8	183..243	CDD:290566
		leucine-rich repeat	185..208	CDD:275380
		leucine-rich repeat	209..232	CDD:275380
		LRR_RI	<225..416	CDD:238064	44/176 (25%)
		LRR_8	232..291	CDD:290566	8/34 (24%)
		leucine-rich repeat	233..256	CDD:275380	76/334 (23%)
		leucine-rich repeat	257..280	CDD:275380	5/22 (23%)
		leucine-rich repeat	281..304	CDD:275380	4/22 (18%)
		LRR_8	304..363	CDD:290566	21/58 (36%)
		leucine-rich repeat	305..328	CDD:275380	8/22 (36%)
		leucine-rich repeat	329..352	CDD:275380	7/22 (32%)
		LRR_8	352..416	CDD:290566	18/80 (23%)
		leucine-rich repeat	353..376	CDD:275380	8/22 (36%)
		LRRCT	414..>450	CDD:214507	9/35 (26%)
Lrit3	XP_006232069.1	LRR_8	61..117	CDD:290566	18/58 (31%)
		LRR_4	83..121	CDD:289563	14/37 (38%)
		leucine-rich repeat	83..106	CDD:275378	8/22 (36%)
		LRR_8	105..165	CDD:290566	17/59 (29%)
		LRR_4	105..146	CDD:289563	13/40 (33%)
		leucine-rich repeat	107..130	CDD:275378	7/22 (32%)
		LRR_4	129..170	CDD:289563	13/48 (27%)
		leucine-rich repeat	131..154	CDD:275378	8/22 (36%)
		leucine-rich repeat	155..168	CDD:275378	3/12 (25%)
		IGc2	268..335	CDD:197706	15/76 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334987
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930