DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Con and Lgr6

DIOPT Version :9

Sequence 1:	NP_001246635.1	Gene:	Con / 38590	FlyBaseID:	FBgn0005775	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	XP_573455.1	Gene:	Lgr6 / 498233	RGDID:	1560339	Length:	965	Species:	Rattus norvegicus

Alignment Length:	366	Identity:	94/366 - (25%)
Similarity:	155/366 - (42%)	Gaps:	50/366 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 CYCTPDE------------NHVPVQKAECWVFSEGLHQNDTTWTR---FYQQKRLRELKFVIQNN 168
            |:|..|.            :.||........:.: |..|:.|..:   |:..:.|.||:.   :.
  Rat    39 CHCQEDGIMLSADCSELGLSEVPADLDPLTAYLD-LSMNNLTELQPGLFHHLRFLEELRL---SG 99

  Fly   169 ARLDYIPTMIIEPLKNLSSIVIEYSQVEIVKSYAFANLPFLERIILNNNHIMALDQDAFANHIRL 233
            ..|.:||......|.:|..::::.:|:..:.:.|...||.|:.:.|:.|.|..:.:.:|.....|
  Rat   100 NHLSHIPRQAFSGLHSLKILMLQSNQLRGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSL 164

  Fly   234 RELNLEHNQIFEMDRYAFRNLPLCERLFLNNNNISTLHEGLFADMARLTFLNLAHNQINVLTSEI 298
            |.|.|:.|.:.|:...|..|||..:.:.|..|.|..:.:..|.::..|..|:|.:|:|..:.:..
  Rat   165 RHLWLDDNALTEIPVRALNNLPALQAMTLALNRIRHIPDYAFQNLTSLVVLHLHNNRIQHVGTHS 229

  Fly   299 FRGLGNLNVLKLTRNNLNFIGDTVFAELWSLSELELDDNRIERISERALDGLNTLKTLNLRNNLL 363
            |.||.||..|.|..|.|... ......|..|.||...:|.|:.|.|:|..|...|:|::..:|.:
  Rat   230 FEGLHNLETLDLNYNELQEF-PVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPI 293

  Fly   364 KKIDNGLLRGTPALLSINVQANKLETLTFYTFQPIMD--NLVNSTS-ELLVSDNKFI-------C 418
            :.:.....:          ..:||.||:......|.:  :|..:|| |:|......|       |
  Rat   294 QFVGRSAFQ----------YLSKLHTLSLNGATDIQEFPDLKGTTSLEILTLTRAGIRLLPAGMC 348

  Fly   419 D--CRLQWIFELKNRTRHLQLRDSLEDLH-C-TLQEPKLSH 455
            .  .||: |.||.    |.|: :.|..|| | .|:|..|.|
  Rat   349 QQLPRLR-ILELS----HNQI-EELPSLHRCQKLEEIGLQH 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Con	NP_001246635.1	LRR_RI	<147..291	CDD:238064	37/146 (25%)
		LRR_8	183..243	CDD:290566	15/59 (25%)
		leucine-rich repeat	185..208	CDD:275380	4/22 (18%)
		leucine-rich repeat	209..232	CDD:275380	5/22 (23%)
		LRR_RI	<225..416	CDD:238064	52/193 (27%)
		LRR_8	232..291	CDD:290566	18/58 (31%)
		leucine-rich repeat	233..256	CDD:275380	9/22 (41%)
		leucine-rich repeat	257..280	CDD:275380	4/22 (18%)
		leucine-rich repeat	281..304	CDD:275380	8/22 (36%)
		LRR_8	304..363	CDD:290566	19/58 (33%)
		leucine-rich repeat	305..328	CDD:275380	6/22 (27%)
		leucine-rich repeat	329..352	CDD:275380	9/22 (41%)
		LRR_8	352..416	CDD:290566	13/66 (20%)
		leucine-rich repeat	353..376	CDD:275380	3/22 (14%)
		LRRCT	414..>450	CDD:214507	14/46 (30%)
Lgr6	XP_573455.1	LRRNT	34..68	CDD:214470	5/28 (18%)
		LRR_RI	<70..248	CDD:238064	49/181 (27%)
		leucine-rich repeat	70..91	CDD:275380	4/21 (19%)
		LRR_8	92..150	CDD:290566	15/60 (25%)
		leucine-rich repeat	92..115	CDD:275380	7/25 (28%)
		leucine-rich repeat	116..139	CDD:275380	4/22 (18%)
		LRR_8	138..198	CDD:290566	18/59 (31%)
		leucine-rich repeat	140..163	CDD:275380	5/22 (23%)
		leucine-rich repeat	164..187	CDD:275380	9/22 (41%)
		LRR_8	186..246	CDD:290566	18/59 (31%)
		leucine-rich repeat	188..211	CDD:275380	4/22 (18%)
		leucine-rich repeat	212..235	CDD:275380	8/22 (36%)
		leucine-rich repeat	236..258	CDD:275380	6/22 (27%)
		LRR_RI	253..>442	CDD:238064	40/147 (27%)
		LRR_8	258..314	CDD:290566	16/65 (25%)
		leucine-rich repeat	259..282	CDD:275380	9/22 (41%)
		leucine-rich repeat	283..304	CDD:275380	3/30 (10%)
		LRR_8	305..364	CDD:290566	18/63 (29%)
		leucine-rich repeat	330..344	CDD:275378	3/13 (23%)
		leucine-rich repeat	354..375	CDD:275380	10/26 (38%)
		LRR_8	375..434	CDD:290566	4/9 (44%)
		leucine-rich repeat	376..399	CDD:275380	4/8 (50%)
		leucine-rich repeat	400..421	CDD:275380
		leucine-rich repeat	424..444	CDD:275380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334975
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840