DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Con and cDIP

DIOPT Version :9

Sequence 1:NP_001246635.1 Gene:Con / 38590 FlyBaseID:FBgn0005775 Length:691 Species:Drosophila melanogaster
Sequence 2:NP_650951.1 Gene:cDIP / 42512 FlyBaseID:FBgn0038865 Length:554 Species:Drosophila melanogaster


Alignment Length:286 Identity:75/286 - (26%)
Similarity:112/286 - (39%) Gaps:71/286 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   239 EHNQIFEMDRYAFRNLPL---------------CERLFLNNNNISTLHEGLFADMARLTFLNLAH 288
            ||::....:...|.|.||               |...|:...|.|     :.||  :|..|.|:.
  Fly    93 EHSRTLIFENCTFTNFPLRLFYTLEVSELDMRGCGIRFIYWENFS-----IGAD--KLVILLLSD 150

  Fly   289 NQINVLTSEIFRGLGNLNVLKLTRNNLNFIGDTVFAELWSLSELELDDNRIERISERALDGLNTL 353
            |.|.||.::.|||.|||..:.|.||.|..:....|..|..|..|:|.:||:|.::.....||.:|
  Fly   151 NHIEVLPTKTFRGAGNLEFIFLNRNKLGKLQAGAFDNLLKLQYLDLTENRLEALAADVFAGLKSL 215

  Fly   354 KTLNLRNNLLKKIDNGLLRGTPALLSINVQANKLETLTFYTFQP--------------------- 397
            :.:.|..|.|..|::.|....|.|||:.:|.|:|..:..|.|:.                     
  Fly   216 RHVGLAGNQLTTIESDLFAHNPDLLSVAMQNNRLREVGEYAFRSRGRHHQMQYVDLSNNPELVVL 280

  Fly   398 --------------IMD--NLVNSTSELLVSDNKFICDCRLQWIFELKNRTRHLQLR-DSLEDLH 445
                          .:|  ||..|.:.:.:|||:.     .:..|.......||.|| :||..|.
  Fly   281 LLNINATNLTARNCSLDRVNLYGSVTNVDLSDNRV-----RELYFPASEALEHLVLRNNSLVQLA 340

  Fly   446 CTLQEPKLSHFVDPVPPTILDVLNIG 471
            ...:.|:|.|.      .:.|..|:|
  Fly   341 SLSRVPRLRHL------DVADNPNLG 360

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ConNP_001246635.1 LRR_RI <147..291 CDD:238064 16/66 (24%)
LRR_8 183..243 CDD:290566 2/3 (67%)
leucine-rich repeat 185..208 CDD:275380
leucine-rich repeat 209..232 CDD:275380
LRR_RI <225..416 CDD:238064 61/228 (27%)
LRR_8 232..291 CDD:290566 16/66 (24%)
leucine-rich repeat 233..256 CDD:275380 4/16 (25%)
leucine-rich repeat 257..280 CDD:275380 6/22 (27%)
leucine-rich repeat 281..304 CDD:275380 10/22 (45%)
LRR_8 304..363 CDD:290566 19/58 (33%)
leucine-rich repeat 305..328 CDD:275380 7/22 (32%)
leucine-rich repeat 329..352 CDD:275380 8/22 (36%)
LRR_8 352..416 CDD:290566 22/100 (22%)
leucine-rich repeat 353..376 CDD:275380 6/22 (27%)
LRRCT 414..>450 CDD:214507 9/36 (25%)
cDIPNP_650951.1 leucine-rich repeat 118..142 CDD:275380 6/30 (20%)
LRR_RI 143..407 CDD:238064 63/229 (28%)
leucine-rich repeat 143..166 CDD:275380 10/22 (45%)
LRR_8 166..225 CDD:290566 19/58 (33%)
leucine-rich repeat 167..190 CDD:275380 7/22 (32%)
leucine-rich repeat 191..214 CDD:275380 8/22 (36%)
leucine-rich repeat 215..238 CDD:275380 6/22 (27%)
leucine-rich repeat 239..265 CDD:275380 8/25 (32%)
leucine-rich repeat 266..325 CDD:275380 8/63 (13%)
LRR_8 304..357 CDD:290566 16/63 (25%)
leucine-rich repeat 326..347 CDD:275380 7/20 (35%)
leucine-rich repeat 348..394 CDD:275380 5/19 (26%)
LRR_8 369..428 CDD:290566
LRR_4 393..433 CDD:289563
leucine-rich repeat 395..418 CDD:275380
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR45617
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
22.010

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