DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Con and tlr22

DIOPT Version :9

Sequence 1:	NP_001246635.1	Gene:	Con / 38590	FlyBaseID:	FBgn0005775	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_001122147.2	Gene:	tlr22 / 403135	ZFINID:	ZDB-GENE-040220-5	Length:	955	Species:	Danio rerio

Alignment Length:	407	Identity:	96/407 - (23%)
Similarity:	169/407 - (41%)	Gaps:	87/407 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 CWVFSE----GLHQNDTTWTRFYQQKRLRELKFVIQNNARL-----------------DYIPTMI 178
            |...||    |...::.:.:.|...|:|::|:..|....|:                 ::|..:.
Zfish   336 CSELSELDLGGNEISNLSQSMFRGFKQLKKLQLQINKLTRVTNSFQILTSLEFIDLSRNHIHKLS 400

  Fly   179 IEPLKNLSSIVIEY---SQVEIVKSYAFANLPFLERIILNNNHIMALDQDAFAN-HIRLRELNLE 239
            .....||:.:...|   :::..::|..|.:|..||.:.|..|:::.:| |.|:| ...|:||.|.
Zfish   401 CNDFANLTQVKTLYLYSNKISSIRSCLFKDLKSLEVLRLGTNNLLKID-DVFSNGPYFLKELQLS 464

  Fly   240 HNQIFEMDRYAFRNLPLCERLFLNNNNISTLHEGLFADMARLTFLNLAHNQI--NVLTS--EIFR 300
            :|::..:..:.|.|||....|.|.:|.||.:....|..:..||.|.|:.|:|  ..||:  .:|.
Zfish   465 YNKLSLIKSHTFGNLPQLNNLSLEDNQISEIEGYAFGGLENLTSLFLSSNKITGKTLTTHPNVFS 529

  Fly   301 GLGNLNVLKLTRNNLNFIGD----TVFAELWSLSELELDDNR--IERISERALDGLNTLKTLNLR 359
            |:.||..|.|..|:::|..|    .:|.:|.:|.||.|...|  |.::....|:||::|:...:.
Zfish   530 GMPNLQNLDLFANSISFAYDKLKYPLFKDLKNLRELSLYSQRRGIGQLPSNLLEGLSSLQMFYIG 594

  Fly   360 NNLLKKIDNGLLRGTPALLSINVQANKL---ETLTFYTFQPIMD--------------------- 400
            |..|.:::..|...||.|..:::..|.|   :.:....|.||.:
Zfish   595 NTNLNQLNPNLFNFTPQLWFLDLSKNALREDDAIPPELFHPIPNLTKLIISRTQLRSLNFLLGAN 659

  Fly   401 -----------NLVNSTSELLV-----------SDNKFICDCRLQWIFELKNRTRHLQLRDSLED 443
                       |.::|.:|.|:           .:|.|.|||...:..:...:....|:. .|..
Zfish   660 LNKLSTLRASGNEIDSVNETLIKSLPRLAVLDLQNNTFTCDCNNAFFIDWAKKNESTQVY-YLSR 723

  Fly   444 LHC----TLQEPKLSHF 456
            ..|    ||:...|:.|
Zfish   724 YTCSYPRTLRGTSLAEF 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Con	NP_001246635.1	LRR_RI	<147..291	CDD:238064	41/164 (25%)
		LRR_8	183..243	CDD:290566	19/63 (30%)
		leucine-rich repeat	185..208	CDD:275380	5/25 (20%)
		leucine-rich repeat	209..232	CDD:275380	8/23 (35%)
		LRR_RI	<225..416	CDD:238064	63/247 (26%)
		LRR_8	232..291	CDD:290566	20/58 (34%)
		leucine-rich repeat	233..256	CDD:275380	8/22 (36%)
		leucine-rich repeat	257..280	CDD:275380	6/22 (27%)
		leucine-rich repeat	281..304	CDD:275380	10/26 (38%)
		LRR_8	304..363	CDD:290566	20/64 (31%)
		leucine-rich repeat	305..328	CDD:275380	8/26 (31%)
		leucine-rich repeat	329..352	CDD:275380	9/24 (38%)
		LRR_8	352..416	CDD:290566	17/109 (16%)
		leucine-rich repeat	353..376	CDD:275380	5/22 (23%)
		LRRCT	414..>450	CDD:214507	10/39 (26%)
tlr22	NP_001122147.2	leucine-rich repeat	458..481	CDD:275380	8/22 (36%)
		LRR_RI	461..700	CDD:238064	59/238 (25%)
		LRR_8	480..544	CDD:290566	22/63 (35%)
		leucine-rich repeat	482..505	CDD:275380	6/22 (27%)
		leucine-rich repeat	506..533	CDD:275380	10/26 (38%)
		leucine-rich repeat	534..561	CDD:275380	8/26 (31%)
		LRR_8	560..622	CDD:290566	17/61 (28%)
		leucine-rich repeat	562..587	CDD:275380	9/24 (38%)
		leucine-rich repeat	588..606	CDD:275380	3/17 (18%)
		leucine-rich repeat	612..638	CDD:275380	6/25 (24%)
		LRR_8	637..695	CDD:290566	4/57 (7%)
		leucine-rich repeat	639..662	CDD:275380	0/22 (0%)
		leucine-rich repeat	663..686	CDD:275380	4/22 (18%)
		leucine-rich repeat	687..705	CDD:275380	5/17 (29%)
		TIR	802..945	CDD:214587
		leucine-rich repeat	71..91	CDD:275380
		LRR_8	91..150	CDD:290566
		leucine-rich repeat	92..115	CDD:275380
		leucine-rich repeat	116..139	CDD:275380
		LRR_8	138..199	CDD:290566
		leucine-rich repeat	140..163	CDD:275380
		leucine-rich repeat	164..213	CDD:275380
		leucine-rich repeat	214..338	CDD:275380	1/1 (100%)
		LRR_8	337..396	CDD:290566	9/58 (16%)
		leucine-rich repeat	339..362	CDD:275380	4/22 (18%)
		LRR_RI	<363..494	CDD:238064	32/131 (24%)
		leucine-rich repeat	363..385	CDD:275380	4/21 (19%)
		LRR_8	384..444	CDD:290566	11/59 (19%)
		leucine-rich repeat	386..409	CDD:275380	3/22 (14%)
		leucine-rich repeat	410..433	CDD:275380	4/22 (18%)
		LRR_8	432..492	CDD:290566	20/60 (33%)
		leucine-rich repeat	434..457	CDD:275380	8/23 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45617
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100