DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Con and caps

DIOPT Version :9

Sequence 1:	NP_001246635.1	Gene:	Con / 38590	FlyBaseID:	FBgn0005775	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_001303391.1	Gene:	caps / 39493	FlyBaseID:	FBgn0023095	Length:	811	Species:	Drosophila melanogaster

Alignment Length:	738	Identity:	150/738 - (20%)
Similarity:	240/738 - (32%)	Gaps:	298/738 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   171 LDYIPTMIIEPLKNLSSIVIEYSQVEIVKS--YAFANLPFLERIILNNNHIMALDQDAFANHIRL 233
            ||.:|..:...::.|   ||:.::::.:.|  ..:|.|.||:   |:.|.::.:.:.:||.|.:|
  Fly    63 LDVLPIALNPAIQRL---VIKNNKLKTIDSSMQFYAQLTFLD---LSFNDMLTIPERSFAYHAKL 121

  Fly   234 RELNLEHNQIFEMDRYAFRNLPLCERLFLNNNNISTLHEGLFADMARLTFLNLAHNQINVLTSEI 298
            :||:|:||:|.::....|..|.....|.|..|.|:.|....|:.|.:|..|||..|:|:.:....
  Fly   122 QELHLDHNKIGQVSNKTFLGLSTISVLNLRGNLIAELEYRTFSPMVKLAELNLGQNRISHIDPHA 186

  Fly   299 FRGLGNLNVLKLTRNNLNFI-GDTVFAELWSLSE------------------------------- 331
            ..||.||.||.|..|.|..: |:..|..|.||:|
  Fly   187 LDGLDNLRVLYLDDNTLTTVPGELTFQALHSLAELYLGTNSFMTIPGGAFQDLKGLTRLDLRGAG 251

  Fly   332 -----------------LELDDNRIERISERALDGLNTLKTLNLRNN------------------ 361
                             |:|.|||:..|...|...|..|:.||:..|
  Fly   252 LHNISGDALKGLVSLRFLDLSDNRLPAIPTAAFQRLGRLEQLNIGQNDFEVISSGAFSGLRELRH 316

  Fly   362 -------LLKKIDNGLLRGTPALLSINVQANK---------LETLTFYTFQPIMDNLVNSTSELL 410
                   .|:::::|...|...|..:|:.:||         |..|...:...:..|.::|..|.|
  Fly   317 LELTGAQRLRRVESGAFSGNTNLEHLNLSSNKQLNELSSIALGGLPHLSTVVLKANQLSSLDEGL 381

  Fly   411 V----------SDNKFICDCRLQWIFELKNRTRHLQLRDSLEDLHC--------TLQEPKLSHFV 457
            |          |:|.|.|||||.|:       |||.:..:....:.        .|::..|:|..
  Fly   382 VPWADLQTLDLSENPFECDCRLLWL-------RHLLVSRNASGQYAPVICAYPTALRDLPLAHLA 439

  Fly   458 DPV---------PPTILDVLNI------------------------------------------- 470
            :|:         ...|:.:|.:
  Fly   440 EPLLGCAHGAASKQAIIGILVVACAALITTLALVLYTCRHRIREMLKGHSALGRKEREYQKTFSD 504

  Fly   471 ------------------GGFTAIGSNSASM-------------------GGVGNSVVGSSYSGL 498
                              ||:..|..||..:                   ||.|.|....:...|
  Fly   505 EEYMSRPPPGGGGVHPAAGGYPYIAGNSRMIPVTELXLEAPPPPQLRGRGGGGGASTASGAVQQL 569

  Fly   499 ----TMDDSRKHLGSRSR---QALRGQRQFASSAENVVESKMRRRRKRQEEVKEKDLAAVAPAHK 556
                .:|.:.......|.   ....||:|.|...::.  |||..        .::|:..:|
  Fly   570 QVPSAVDQASNSFAQLSHIHYMTNNGQQQQAQQQQST--SKMHH--------SQQDMRLLA---- 620

  Fly   557 RYDYYDDNNGGMSLGHGLDLDDNLSLHKQGFYGAGSPVVGHNDVDVLMTSHSASGDALDILTTKN 621
                   .|||..|.     ..:|..|:       .|||..:.:     ||.:...|..|..|::
  Fly   621 -------CNGGKPLN-----ATSLPRHR-------PPVVQESTL-----SHYSQPLANGIRLTQD 661

  Fly   622 ---------------AIYIKLFLLKPEMLPCHDELSDP--------TELPLSRDL---------- 653
                           .:|.|         || |.:|:|        ..|||..||
  Fly   662 HFNHNQNQSHNQHYGGVYAK---------PC-DAMSEPGYIHNNSHYSLPLDHDLPPSPTPTPPP 716

  Fly   654 --MDVRSNVGQDM---STAGANS 671
              :.:|:.||..:   :|.|..|
  Fly   717 PALPLRNGVGMALIHGNTTGRRS 739

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Con	NP_001246635.1	LRR_RI	<147..291	CDD:238064	37/121 (31%)
		LRR_8	183..243	CDD:290566	19/61 (31%)
		leucine-rich repeat	185..208	CDD:275380	6/24 (25%)
		leucine-rich repeat	209..232	CDD:275380	6/22 (27%)
		LRR_RI	<225..416	CDD:238064	68/283 (24%)
		LRR_8	232..291	CDD:290566	21/58 (36%)
		leucine-rich repeat	233..256	CDD:275380	9/22 (41%)
		leucine-rich repeat	257..280	CDD:275380	7/22 (32%)
		leucine-rich repeat	281..304	CDD:275380	8/22 (36%)
		LRR_8	304..363	CDD:290566	25/132 (19%)
		leucine-rich repeat	305..328	CDD:275380	9/23 (39%)
		leucine-rich repeat	329..352	CDD:275380	10/70 (14%)
		LRR_8	352..416	CDD:290566	20/107 (19%)
		leucine-rich repeat	353..376	CDD:275380	7/47 (15%)
		LRRCT	414..>450	CDD:214507	12/43 (28%)
caps	NP_001303391.1	leucine-rich repeat	75..96	CDD:275380	4/23 (17%)
		LRR_8	96..155	CDD:290566	20/61 (33%)
		leucine-rich repeat	97..120	CDD:275380	8/25 (32%)
		leucine-rich repeat	121..144	CDD:275380	9/22 (41%)
		LRR_8	143..201	CDD:290566	20/57 (35%)
		leucine-rich repeat	145..168	CDD:275380	7/22 (32%)
		LRR_RI	147..397	CDD:238064	56/249 (22%)
		leucine-rich repeat	169..192	CDD:275380	8/22 (36%)
		leucine-rich repeat	193..217	CDD:275380	9/23 (39%)
		LRR_8	217..276	CDD:290566	7/58 (12%)
		leucine-rich repeat	218..241	CDD:275380	2/22 (9%)
		leucine-rich repeat	242..265	CDD:275380	0/22 (0%)
		LRR_8	265..321	CDD:290566	12/55 (22%)
		leucine-rich repeat	266..289	CDD:275380	8/22 (36%)
		leucine-rich repeat	290..313	CDD:275380	4/22 (18%)
		LRR_8	312..374	CDD:290566	10/61 (16%)
		leucine-rich repeat	314..335	CDD:275380	2/20 (10%)
		leucine-rich repeat	339..363	CDD:275380	6/23 (26%)
		LRRCT	395..445	CDD:214507	15/56 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45617
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010