DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Con and 18w

DIOPT Version :9

Sequence 1:	NP_001246635.1	Gene:	Con / 38590	FlyBaseID:	FBgn0005775	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_476814.1	Gene:	18w / 37277	FlyBaseID:	FBgn0004364	Length:	1385	Species:	Drosophila melanogaster

Alignment Length:	414	Identity:	102/414 - (24%)
Similarity:	189/414 - (45%)	Gaps:	46/414 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 LKNLSSIVIEYSQVEIVKSYAFANLPFLERIILNNNHIMALDQDAFANHIRLRELNLEHNQIFEM 246
            |:.|.::.::::.:..:...|.|.|..|..:.::.||:::|..:|||.:..||||:|:.|.::|:
  Fly   234 LRRLQTLSLQHNNISTLAPNALAGLSSLRVLNISYNHLVSLPSEAFAGNKELRELHLQGNDLYEL 298

  Fly   247 DRYAFRNLPLCERLFLNNNNISTLH--EGLFADMARLTFLNLAHNQINVLTSEIFRGLGNLNVLK 309
            .:.....|.....|.|:.|.:::.|  ...||.:.||..|||::|.:..:.|:.|:.|..|.:|.
  Fly   299 PKGLLHRLEQLLVLDLSGNQLTSHHVDNSTFAGLIRLIVLNLSNNALTRIGSKTFKELYFLQILD 363

  Fly   310 LTRNNLNFIGDTVFAELWSLSELELDDNRIERISERALDGLNTLKTLNLRNNLLKKIDNGLLRGT 374
            :..|::..|.:..|..|::|..|.|.:||:..:..|..:||..|..|.|.|||:..:::...|..
  Fly   364 MRNNSIGHIEEGAFLPLYNLHTLNLAENRLHTLDNRIFNGLYVLTKLTLNNNLVSIVESQAFRNC 428

  Fly   375 PALLSINVQANKLETLTFYTFQPIMDNLVNSTSELLVSDNKFICDCRLQWIFELKNRT-RHLQLR 438
            ..|..:::.:|:|..:.    :.:.|..:..|.:|  .:|:         |.|.||.| |:|...
  Fly   429 SDLKELDLSSNQLTEVP----EAVQDLSMLKTLDL--GENQ---------ISEFKNNTFRNLNQL 478

  Fly   439 DSLEDLHCTLQEPKLSHFVDPVPPTILDVLNI----------GGF------TAIGSNSASMGGVG 487
            ..|..:...:....:..|.| :|.  |.|||:          |.|      .||..:...:..:
  Fly   479 TGLRLIDNRIGNITVGMFQD-LPR--LSVLNLAKNRIQSIERGAFDKNTEIEAIRLDKNFLTDI- 539

  Fly   488 NSVVGSSYSGLTMDDSRKHLGSRSRQALRGQRQFASSAENVVESKMRRRRKRQEEVKEKDLAAVA 552
            |.:..:..|.|.::.|..||.......:....::.....|.:|: :....|.|||::...|.|
  Fly   540 NGIFATLASLLWLNLSENHLVWFDYAFIPSNLKWLDIHGNYIEA-LGNYYKLQEEIRVTTLDA-- 601

  Fly   553 PAHKRYDYYDDNNGGMSLGHGLDL 576
             :|.|.    ...|.||:.:.::|
  Fly   602 -SHNRI----TEIGAMSVPNSIEL 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Con	NP_001246635.1	LRR_RI	<147..291	CDD:238064	32/110 (29%)
		LRR_8	183..243	CDD:290566	17/59 (29%)
		leucine-rich repeat	185..208	CDD:275380	4/22 (18%)
		leucine-rich repeat	209..232	CDD:275380	7/22 (32%)
		LRR_RI	<225..416	CDD:238064	54/192 (28%)
		LRR_8	232..291	CDD:290566	20/60 (33%)
		leucine-rich repeat	233..256	CDD:275380	8/22 (36%)
		leucine-rich repeat	257..280	CDD:275380	6/24 (25%)
		leucine-rich repeat	281..304	CDD:275380	8/22 (36%)
		LRR_8	304..363	CDD:290566	19/58 (33%)
		leucine-rich repeat	305..328	CDD:275380	6/22 (27%)
		leucine-rich repeat	329..352	CDD:275380	8/22 (36%)
		LRR_8	352..416	CDD:290566	14/63 (22%)
		leucine-rich repeat	353..376	CDD:275380	7/22 (32%)
		LRRCT	414..>450	CDD:214507	9/36 (25%)
18w	NP_476814.1	leucine-rich repeat	66..91	CDD:275380
		leucine-rich repeat	92..115	CDD:275380
		LRR_8	115..181	CDD:290566
		leucine-rich repeat	116..146	CDD:275380
		leucine-rich repeat	147..170	CDD:275380
		leucine-rich repeat	171..201	CDD:275380
		LRR_RI	210..464	CDD:238064	63/244 (26%)
		leucine-rich repeat	212..236	CDD:275380	1/1 (100%)
		LRR_8	235..295	CDD:290566	17/59 (29%)
		leucine-rich repeat	237..260	CDD:275380	4/22 (18%)
		leucine-rich repeat	261..284	CDD:275380	7/22 (32%)
		LRR_8	283..345	CDD:290566	20/61 (33%)
		leucine-rich repeat	285..308	CDD:275380	8/22 (36%)
		leucine-rich repeat	309..334	CDD:275380	6/24 (25%)
		LRR_8	334..393	CDD:290566	19/58 (33%)
		leucine-rich repeat	335..358	CDD:275380	8/22 (36%)
		leucine-rich repeat	359..382	CDD:275380	6/22 (27%)
		LRR_8	382..441	CDD:290566	17/58 (29%)
		leucine-rich repeat	383..406	CDD:275380	8/22 (36%)
		leucine-rich repeat	407..430	CDD:275380	7/22 (32%)
		LRR_8	431..488	CDD:290566	15/71 (21%)
		leucine-rich repeat	431..451	CDD:275380	3/23 (13%)
		leucine-rich repeat	454..477	CDD:275380	10/33 (30%)
		LRR_8	477..559	CDD:290566	16/85 (19%)
		leucine-rich repeat	478..499	CDD:275380	3/21 (14%)
		leucine-rich repeat	502..525	CDD:275380	6/22 (27%)
		leucine-rich repeat	526..548	CDD:275380	3/22 (14%)
		leucine-rich repeat	590..617	CDD:275380	10/33 (30%)
		leucine-rich repeat	618..641	CDD:275380	1/3 (33%)
		leucine-rich repeat	642..689	CDD:275380
		LRRCT	679..736	CDD:214507
		leucine-rich repeat	775..796	CDD:275380
		LRR_8	797..852	CDD:290566
		leucine-rich repeat	797..817	CDD:275380
		leucine-rich repeat	818..841	CDD:275380
		LRR_8	841..900	CDD:290566
		leucine-rich repeat	842..865	CDD:275380
		LRR_4	866..907	CDD:289563
		leucine-rich repeat	866..889	CDD:275380
		leucine-rich repeat	890..911	CDD:275380
		TIR	1045..1183	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45617
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010