DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Con and Lrg1

DIOPT Version :9

Sequence 1:NP_001246635.1 Gene:Con / 38590 FlyBaseID:FBgn0005775 Length:691 Species:Drosophila melanogaster
Sequence 2:XP_038939951.1 Gene:Lrg1 / 367455 RGDID:1359464 Length:342 Species:Rattus norvegicus


Alignment Length:290 Identity:72/290 - (24%)
Similarity:113/290 - (38%) Gaps:69/290 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   236 LNLEHNQIFEMDRYAFRNLPLCERLFLNNNNISTLHEGLFADMARLTFLNLAHNQINVLTSEIFR 300
            |::|.:.:.::...|.:..|..:.|.|::|.:..|..||.|.:.||..|:|..|.:..|...:||
  Rat    66 LSVEFSSLTQLPAAALQGCPGLQELHLSSNRLQELSPGLLAPVPRLRVLDLTRNALRSLPPGLFR 130

  Fly   301 GLGNLNVLKLTRNNLNFIGDTVFAELWSLSELELDDNRIERISERALDGLNTLKTLNLRNNLLKK 365
            ....||.|.|..|.|..........|.:|..|:|.:||:..:..|.|..|..|.||:|.:|||:.
  Rat   131 SSAALNTLVLRENQLQEASARWLQGLDALGYLDLAENRLRSLPARLLANLGALHTLDLGHNLLES 195

  Fly   366 IDNGLLRGTPALLSINVQANKLETLTFYTFQP--------------------------------I 398
            :..|.|||...|..::::.|:|:.|......|                                :
  Rat   196 LPEGFLRGPRRLQRLHLEGNRLQRLEAGLLAPQPFLGVLFLNDNQLTAVAADSFRGLKQLDMLDL 260

  Fly   399 MDNLVNSTSELL----------------VSDNKFICD------CRLQWIFELKNRTRHLQLRDSL 441
            .:|.::||...|                ||.|.::||      ||  |:  ..||.:.....|:|
  Rat   261 SNNSLSSTPPGLWAFLGRPTRDMQDGFDVSHNPWVCDKDLVDLCR--WL--AANRHKMFSQNDTL 321

  Fly   442 EDLHCTLQEPKLSHFVDPVPPTILDVLNIG 471
                |...|.....       .:|||..:|
  Rat   322 ----CAGPEAVRGQ-------RLLDVAELG 340

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ConNP_001246635.1 LRR_RI <147..291 CDD:238064 16/54 (30%)
LRR_8 183..243 CDD:290566 2/6 (33%)
leucine-rich repeat 185..208 CDD:275380
leucine-rich repeat 209..232 CDD:275380
LRR_RI <225..416 CDD:238064 57/227 (25%)
LRR_8 232..291 CDD:290566 16/54 (30%)
leucine-rich repeat 233..256 CDD:275380 3/19 (16%)
leucine-rich repeat 257..280 CDD:275380 7/22 (32%)
leucine-rich repeat 281..304 CDD:275380 7/22 (32%)
LRR_8 304..363 CDD:290566 20/58 (34%)
leucine-rich repeat 305..328 CDD:275380 7/22 (32%)
leucine-rich repeat 329..352 CDD:275380 8/22 (36%)
LRR_8 352..416 CDD:290566 23/111 (21%)
leucine-rich repeat 353..376 CDD:275380 11/22 (50%)
LRRCT 414..>450 CDD:214507 11/41 (27%)
Lrg1XP_038939951.1 PRK15370 <55..>293 CDD:185268 56/226 (25%)
leucine-rich repeat 65..86 CDD:275380 3/19 (16%)
leucine-rich repeat 87..110 CDD:275380 7/22 (32%)
leucine-rich repeat 111..134 CDD:275380 7/22 (32%)
leucine-rich repeat 135..158 CDD:275380 7/22 (32%)
leucine-rich repeat 159..182 CDD:275380 8/22 (36%)
leucine-rich repeat 183..206 CDD:275380 11/22 (50%)
leucine-rich repeat 207..230 CDD:275380 5/22 (23%)
leucine-rich repeat 231..254 CDD:275380 0/22 (0%)
leucine-rich repeat 255..278 CDD:275380 4/22 (18%)
PCC 259..>339 CDD:188093 21/94 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166334983
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.930

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