DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Con and conv

DIOPT Version :9

Sequence 1:	NP_001246635.1	Gene:	Con / 38590	FlyBaseID:	FBgn0005775	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_001286416.1	Gene:	conv / 36588	FlyBaseID:	FBgn0261269	Length:	1092	Species:	Drosophila melanogaster

Alignment Length:	565	Identity:	131/565 - (23%)
Similarity:	230/565 - (40%)	Gaps:	135/565 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 RLRELKFVIQNNARLDYIPTMIIEPLKNLSSIVIEYSQVEIVKSYAFANLPFLERIILNNNHIMA 221
            :|.||..:..::..:..|...:.:.|.:|.||.:.::.:..:||..|..||.|..:.|::|.:::
  Fly   459 KLYELHTIDVSHNNISSIFNGVFQTLFSLRSIDLSHNSMREIKSSTFGTLPTLLEMDLSHNELVS 523

  Fly   222 LDQDAFANHIRLRELNLEHNQIFEMDRYAFRNLPL-CERLFLNNNNISTLHEGLFADMARLTFLN 285
            :.:.:.|....||:|.|.:||:.::.:     ||: ...|:.::|.::.:..|.:..|..|.:|:
  Fly   524 VVRGSLAKLTSLRQLYLNNNQLEKLFQ-----LPISLNELYFSHNRLTNIPSGTWPVMNSLIYLD 583

  Fly   286 LAHNQI-NVLTSEIFRGL------------------------GNLNVLKLTRNNLNFIGDTVFAE 325
            |:|||: :.|..|.|.||                        ..|..|.|..||:..:..:.|.:
  Fly   584 LSHNQLGDTLNGESFTGLLVVQRLKLQNNGISQPPKDAVAVMSTLQYLHLENNNITTLERSAFGK 648

  Fly   326 LWSLSELELDDNRIERISERALDGLNTLKTLNLRNNLLKKIDNGLLRGTPALLSINVQAN----- 385
            |..|.||.|..|:::.||:||.:||..|.||||.:|.::.:.|.:..|.|:|.::::..|
  Fly   649 LPVLFELNLYGNQVKDISKRAFEGLLQLLTLNLSSNGIQTLQNDIFVGLPSLRNLDLSFNSLTKL 713

  Fly   386 ------------KLETL-------------TFYTFQPIMDNLVN-----------------STSE 408
                        .||||             ||.:.|.|..||.|                 .|.:
  Fly   714 DNKTNGVLDDLLSLETLDLSHNRISFVTKKTFPSHQYIPYNLRNLNLSYNLMPILTYDITFGTKK 778

  Fly   409 LL---VSDNKFICDCR---------LQWIFELKNRTRHLQLRDSLEDLHCTLQEPKLSH-FVDPV 460
            |:   ||.|: |.|.|         ||.:....|...:|:..:.:.||...|....||| .:..:
  Fly   779 LVRLDVSHNQ-INDLRRGVISNFTSLQSLDMSYNELSNLKSEEHIFDLPQNLSWLDLSHNKIYHL 842

  Fly   461 PPTILDVLNIGGFTAIGSNSASMGGVGNSVVGSSYSG--LTMDDSRKHLGSRSRQALRGQRQFAS 523
            |  ..:::.:.....:...:.|:..|..|:|||..:|  :.:..:..|.|..:|..    :.|
  Fly   843 P--FANLVKVKSLKYVDLTNNSLEDVPASIVGSMRNGSQVLLAGNPLHCGCNARPL----KYF-- 899

  Fly   524 SAENVVESKMRRRRKRQEEVKEKDLAAV---APA---HKRYDYYDDN-----NGGMSLGHGLDLD 577
                          ..|:.:..:||.::   .||   .|:....||.     .....:..|:|.:
  Fly   900 --------------MLQQTIAGEDLKSIYCGTPALIKDKQLISLDDEYLHCAEDEQEMYKGIDYE 950

  Fly   578 D-------NLSLHKQGFYGAGSPVVGHNDV-DVLMTSHSASGDAL 614
            .       .:..:|.|.......|.|.:|| |..:...|:|.|.|
  Fly   951 QLTDVRFREVKTNKAGMLTLCWYVSGFSDVSDFHVYIRSSSNDVL 995

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Con	NP_001246635.1	LRR_RI	<147..291	CDD:238064	34/134 (25%)
		LRR_8	183..243	CDD:290566	17/59 (29%)
		leucine-rich repeat	185..208	CDD:275380	7/22 (32%)
		leucine-rich repeat	209..232	CDD:275380	4/22 (18%)
		LRR_RI	<225..416	CDD:238064	69/266 (26%)
		LRR_8	232..291	CDD:290566	17/59 (29%)
		leucine-rich repeat	233..256	CDD:275380	7/22 (32%)
		leucine-rich repeat	257..280	CDD:275380	4/22 (18%)
		leucine-rich repeat	281..304	CDD:275380	11/47 (23%)
		LRR_8	304..363	CDD:290566	24/58 (41%)
		leucine-rich repeat	305..328	CDD:275380	7/22 (32%)
		leucine-rich repeat	329..352	CDD:275380	11/22 (50%)
		LRR_8	352..416	CDD:290566	27/113 (24%)
		leucine-rich repeat	353..376	CDD:275380	8/22 (36%)
		LRRCT	414..>450	CDD:214507	11/44 (25%)
conv	NP_001286416.1	leucine-rich repeat	125..148	CDD:275380
		leucine-rich repeat	150..175	CDD:275380
		leucine-rich repeat	176..199	CDD:275380
		LRR_8	198..258	CDD:290566
		leucine-rich repeat	200..223	CDD:275380
		LRR_RI	201..545	CDD:238064	22/85 (26%)
		leucine-rich repeat	224..271	CDD:275380
		LRR_8	245..306	CDD:290566
		leucine-rich repeat	272..295	CDD:275380
		LRR_8	296..354	CDD:290566
		leucine-rich repeat	296..319	CDD:275380
		LRR_8	322..401	CDD:290566
		leucine-rich repeat	322..343	CDD:275380
		leucine-rich repeat	344..367	CDD:275380
		leucine-rich repeat	371..390	CDD:275380
		leucine-rich repeat	391..414	CDD:275380
		leucine-rich repeat	416..438	CDD:275380
		LRR_8	437..495	CDD:290566	8/35 (23%)
		leucine-rich repeat	439..462	CDD:275380	1/2 (50%)
		leucine-rich repeat	463..486	CDD:275380	3/22 (14%)
		LRR_RI	486..738	CDD:238064	68/256 (27%)
		LRR_8	486..545	CDD:290566	17/58 (29%)
		leucine-rich repeat	487..510	CDD:275380	7/22 (32%)
		leucine-rich repeat	511..534	CDD:275380	4/22 (18%)
		leucine-rich repeat	535..554	CDD:275380	8/23 (35%)
		LRR_8	554..614	CDD:290566	15/59 (25%)
		leucine-rich repeat	555..578	CDD:275380	4/22 (18%)
		leucine-rich repeat	579..603	CDD:275380	11/23 (48%)
		leucine-rich repeat	604..627	CDD:275380	0/22 (0%)
		LRR_8	626..710	CDD:290566	29/83 (35%)
		leucine-rich repeat	628..649	CDD:275380	6/20 (30%)
		leucine-rich repeat	652..672	CDD:275380	9/19 (47%)
		LRR_8	698..765	CDD:290566	14/66 (21%)
		leucine-rich repeat	700..726	CDD:275380	2/25 (8%)
		leucine-rich repeat	727..745	CDD:275380	4/17 (24%)
		LRR_8	777..839	CDD:290566	17/62 (27%)
		leucine-rich repeat	779..802	CDD:275380	7/23 (30%)
		leucine-rich repeat	829..852	CDD:275380	5/24 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45617
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010