DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Con and Tril

DIOPT Version :9

Sequence 1:	NP_001246635.1	Gene:	Con / 38590	FlyBaseID:	FBgn0005775	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_001029182.1	Gene:	Tril / 362364	RGDID:	1310827	Length:	811	Species:	Rattus norvegicus

Alignment Length:	522	Identity:	124/522 - (23%)
Similarity:	195/522 - (37%)	Gaps:	140/522 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 PMDSTGFCTRRRDMK----LMC-----YCTPDENHVPVQKAECWVFSEGLHQNDTTWTRFYQQKR 157
            |..:...|..|.|.:    |:|     ...|..:.:|..:.   |.:..|..|..|....:...|
  Rat    20 PPRAESVCPERCDCQHPQHLLCTNRGLRAVPKTSSLPSPQD---VLTYSLGGNFITNITAFDFHR 81

  Fly   158 LRELKFVIQNNARLDYIPTMIIEPLKNLSSIVIEYSQVEIVKSYAFANLPFLERIILNNNHIMAL 222
            |.:|:       |||                 ::|:|:..:....|..|..||.:.|.||.:.||
  Rat    82 LGQLR-------RLD-----------------LQYNQIRSLHPKTFEKLSRLEELYLGNNLLQAL 122

  Fly   223 DQDAFANHIRLRELNLEHNQIFEMDRYAFRNLPLCERLFLNNNNISTLHEGLFADMARLTFLNLA 287
            .....|...:||.|....|:|..:.|.:|..|....:|.|:.|.:..|.:.:||.:..|.:|:|.
  Rat   123 APGTLAPLRKLRILYANGNEIGRLSRGSFEGLESLVKLRLDGNVLGALPDAVFAPLGNLLYLHLE 187

  Fly   288 HNQINVLTSEIFRGLG--------------------------NLNVLKLTRNNLNFIGDTVFAEL 326
            .|:|..|....|..||                          :|:.|.|:.|:|..:|..||..|
  Rat   188 ANRIRFLGKNAFTQLGKLRFLNLSANELQPSLRHAATFVPLRSLSTLILSANSLQHLGPRVFQHL 252

  Fly   327 WSLSELELDDNRIERISERALDGLNTLKTLNLRNNLLKKIDNGLLRGTPALLSINVQANKLETLT 391
            ..|..|.|..|::..::..|..||..|:.|.|..|.|.::...||....:|.::::..|:|..|.
  Rat   253 PRLGLLSLSGNQLTHLAPEAFWGLEALRELRLEGNRLNQLPLTLLEPLHSLEALDLSGNELSALH 317

  Fly   392 FYTF--------QPIMDNLVNSTS-----------ELLVSDNKFICDCRLQ--------WIFELK 429
            ..||        ..:.||.:::.|           .|.:..|.:.|||||:        |..:.:
  Rat   318 PATFGHQGRLRELSLRDNALSALSGDIFAASPALYRLDLDGNGWTCDCRLRGLKRWMGNWHSQGR 382

  Fly   430 NRTRHLQLR----------DSLEDLHCTLQEPKLSHFVDPVP-PTILDVLNIGG-----FTAIGS 478
            ..|..:|.|          |.|:|     |..:....|||.| ||      .|.     .||.|.
  Rat   383 LLTVFVQCRHPPALRGKYLDYLDD-----QLLQNGSCVDPSPSPT------AGSRQWPISTAPGE 436

  Fly   479 NSASMGGV---------------GNSVVGSSYSGLTMDDSRKHLGSRSRQAL--RG---QRQFAS 523
            ......|:               |..:.|.:::|.    :::.:|:||...|  ||   |.|..|
  Rat   437 GMTPPAGLAQELPLQPQPQPQQRGRLLPGVAWAGA----AKELVGNRSALRLNRRGPGLQHQSPS 497

  Fly   524 SA 525
            :|
  Rat   498 AA 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Con	NP_001246635.1	LRR_RI	<147..291	CDD:238064	37/143 (26%)
		LRR_8	183..243	CDD:290566	16/59 (27%)
		leucine-rich repeat	185..208	CDD:275380	4/22 (18%)
		leucine-rich repeat	209..232	CDD:275380	8/22 (36%)
		LRR_RI	<225..416	CDD:238064	58/235 (25%)
		LRR_8	232..291	CDD:290566	18/58 (31%)
		leucine-rich repeat	233..256	CDD:275380	8/22 (36%)
		leucine-rich repeat	257..280	CDD:275380	6/22 (27%)
		leucine-rich repeat	281..304	CDD:275380	9/48 (19%)
		LRR_8	304..363	CDD:290566	20/58 (34%)
		leucine-rich repeat	305..328	CDD:275380	9/22 (41%)
		leucine-rich repeat	329..352	CDD:275380	7/22 (32%)
		LRR_8	352..416	CDD:290566	18/82 (22%)
		leucine-rich repeat	353..376	CDD:275380	7/22 (32%)
		LRRCT	414..>450	CDD:214507	13/53 (25%)
Tril	NP_001029182.1	LRR_RI	22..313	CDD:238064	77/317 (24%)
		leucine-rich repeat	37..57	CDD:275378	3/19 (16%)
		LRR 1	61..81		4/19 (21%)
		LRR_8	84..143	CDD:290566	20/82 (24%)
		LRR 2	84..105		7/44 (16%)
		leucine-rich repeat	85..108	CDD:275380	8/46 (17%)
		LRR 3	108..129		7/20 (35%)
		leucine-rich repeat	109..132	CDD:275380	8/22 (36%)
		LRR 4	132..153		7/20 (35%)
		leucine-rich repeat	133..156	CDD:275380	8/22 (36%)
		LRR_8	156..215	CDD:290566	15/58 (26%)
		LRR 5	156..177		5/20 (25%)
		leucine-rich repeat	157..180	CDD:275380	6/22 (27%)
		LRR 6	180..201		7/20 (35%)
		leucine-rich repeat	181..204	CDD:275380	8/22 (36%)
		LRR 7	204..223		0/18 (0%)
		leucine-rich repeat	205..230	CDD:275380	0/24 (0%)
		LRR_8	229..289	CDD:290566	20/59 (34%)
		LRR 8	230..251		8/20 (40%)
		leucine-rich repeat	231..254	CDD:275380	9/22 (41%)
		LRR 9	254..275		5/20 (25%)
		leucine-rich repeat	255..278	CDD:275380	7/22 (32%)
		LRR 10	278..298		6/19 (32%)
		leucine-rich repeat	279..302	CDD:275380	7/22 (32%)
		LRR_8	302..359	CDD:290566	10/56 (18%)
		LRR 11	302..323		6/20 (30%)
		leucine-rich repeat	303..323	CDD:275380	6/19 (32%)
		LRR 12	326..347		3/20 (15%)
		leucine-rich repeat	327..340	CDD:275378	2/12 (17%)
		leucine-rich repeat	351..363	CDD:275378	2/11 (18%)
		TPKR_C2	359..406	CDD:301599	12/46 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	414..460		11/51 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	486..562		6/14 (43%)
		FN3	589..661	CDD:214495
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334981
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930