DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Con and Lgi4

DIOPT Version :9

Sequence 1:NP_001246635.1 Gene:Con / 38590 FlyBaseID:FBgn0005775 Length:691 Species:Drosophila melanogaster
Sequence 2:NP_955793.1 Gene:Lgi4 / 361549 RGDID:735035 Length:537 Species:Rattus norvegicus


Alignment Length:283 Identity:77/283 - (27%)
Similarity:115/283 - (40%) Gaps:65/283 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   268 STLHEG------LFADMARLTFLNLAHNQINVLTSEIFRGLGNLNVLKLTRNNLNFIGDTVFAEL 326
            |||.||      .|:  ..|..|:|....::.|.:..|..:.:|::|..|.|..:.|....|..|
  Rat    37 STLCEGSPELPESFS--TTLLSLSLVRMGVSRLKAGSFLKMPSLHLLLFTSNTFSVIEGDAFIGL 99

  Fly   327 WSLSELELDDNRIERISERALDGLNTLKTLNLRNNLLKKIDNGLLRGTPALLSINVQANKLETLT 391
            ..|..|.::||:|..||:.||.||.:|..|:|.||.|:.:...|.:|             |||||
  Rat   100 SYLQYLFIEDNKIGSISKNALRGLRSLTHLSLANNHLEALPRFLFQG-------------LETLT 151

  Fly   392 FYTFQPIMDNLVNSTSELLVSDNKFICDCRLQWIFELKNRTRHLQLRDSLEDLHC----TLQEPK 452
            ....:                .|.|.||||:.|:.:...     .:..|:....|    .|.:.:
  Rat   152 HVDLR----------------GNPFQCDCRVLWLLQWMP-----MVNASVGTGACAGPSALAQIQ 195

  Fly   453 LSHFVDP----VPPTILDVLNIGGFTAIGSNSASMGGVGNSVVGSSYSG----LTMDDSRKHLGS 509
            |:| :||    ...|.|..|...|.:|:...|.|..|..:.|:...::|    |..|.|.:..  
  Rat   196 LNH-LDPKKFKCKATELSWLQTVGESALSVESFSYQGEPHMVLAQPFAGRCLILVWDYSLQRF-- 257

  Fly   510 RSRQALRGQRQFASSAENVVESK 532
            ||.:.|        ||.:||..|
  Rat   258 RSEEEL--------SAPSVVSCK 272

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ConNP_001246635.1 LRR_RI <147..291 CDD:238064 9/28 (32%)
LRR_8 183..243 CDD:290566
leucine-rich repeat 185..208 CDD:275380
leucine-rich repeat 209..232 CDD:275380
LRR_RI <225..416 CDD:238064 43/153 (28%)
LRR_8 232..291 CDD:290566 9/28 (32%)
leucine-rich repeat 233..256 CDD:275380
leucine-rich repeat 257..280 CDD:275380 6/17 (35%)
leucine-rich repeat 281..304 CDD:275380 5/22 (23%)
LRR_8 304..363 CDD:290566 23/58 (40%)
leucine-rich repeat 305..328 CDD:275380 7/22 (32%)
leucine-rich repeat 329..352 CDD:275380 11/22 (50%)
LRR_8 352..416 CDD:290566 14/63 (22%)
leucine-rich repeat 353..376 CDD:275380 8/22 (36%)
LRRCT 414..>450 CDD:214507 10/39 (26%)
Lgi4NP_955793.1 leucine-rich repeat 54..77 CDD:275378 5/22 (23%)
LRR_8 76..136 CDD:290566 23/59 (39%)
leucine-rich repeat 78..101 CDD:275378 7/22 (32%)
LRR_4 102..140 CDD:289563 17/37 (46%)
leucine-rich repeat 102..125 CDD:275378 11/22 (50%)
leucine-rich repeat 126..149 CDD:275378 9/35 (26%)
leucine-rich repeat 150..162 CDD:275378 4/27 (15%)
LRRCT 158..207 CDD:214507 14/54 (26%)
EPTP <220..251 CDD:281697 7/30 (23%)
EPTP 351..392 CDD:281697
EPTP 396..438 CDD:281697
EPTP 441..482 CDD:281697
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166334997
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X486
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.930

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