DRSC/TRiP Functional Genomics Resources

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Protein Alignment Con and LRIT3

DIOPT Version :9

Sequence 1:NP_001246635.1 Gene:Con / 38590 FlyBaseID:FBgn0005775 Length:691 Species:Drosophila melanogaster
Sequence 2:NP_940908.3 Gene:LRIT3 / 345193 HGNCID:24783 Length:679 Species:Homo sapiens


Alignment Length:252 Identity:69/252 - (27%)
Similarity:110/252 - (43%) Gaps:31/252 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly   249 YAFRNLPLCERLFL-NNNNISTLHEGLFADMARLTFLNLAHNQINVLTSEIFRGLGNLNVLKLTR 312
            |..||.....||.| |:.:::.|...|..|..:   |.:....|..:::|.|..|..|..|.:|.
Human    29 YHGRNDGSGSRLVLCNDMDMNELPTNLPVDTVK---LRIEKTVIRRISAEAFYYLVELQYLWVTY 90

  Fly   313 NNLNFIGDTVFAELWSLSELELDDNRIERISERALDGLNTLKTLNLRNNLLKKIDNGLLRGTPAL 377
            |::..|..:.|..|..|.||.||.|.:......:|..:..|:||:|.||.:..:.|..||....|
Human    91 NSVASIDPSSFYNLKQLHELRLDGNSLAAFPWASLLDMPLLRTLDLHNNKITSVPNEALRYLKNL 155

  Fly   378 LSINVQANKLETLTFYTFQPIMDNLVNSTSELL----------VSDNKFICDCRLQWIFEL-KNR 431
            ..:::.:|:|.||. ..|.....:||::.|.:|          :.||.:.|||.:..:.|| |..
Human   156 AYLDLSSNRLTTLP-PDFLESWTHLVSTPSGVLDLSPSRIILGLQDNPWFCDCHISKMIELSKVV 219

  Fly   432 TRHLQLRDSLEDLHCT---------LQEPKLSHFVDPVPPTILDVLNIGGFTAIGSN 479
            ...:.|.|.|  :.|:         .|..:|.|.:.|...|....:    .:|:|||
Human   220 DPAIVLLDPL--MTCSEPERLTGILFQRAELEHCLKPSVMTSATKI----MSALGSN 270

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ConNP_001246635.1 LRR_RI <147..291 CDD:238064 11/42 (26%)
LRR_8 183..243 CDD:290566
leucine-rich repeat 185..208 CDD:275380
leucine-rich repeat 209..232 CDD:275380
LRR_RI <225..416 CDD:238064 50/177 (28%)
LRR_8 232..291 CDD:290566 11/42 (26%)
leucine-rich repeat 233..256 CDD:275380 3/6 (50%)
leucine-rich repeat 257..280 CDD:275380 7/23 (30%)
leucine-rich repeat 281..304 CDD:275380 5/22 (23%)
LRR_8 304..363 CDD:290566 20/58 (34%)
leucine-rich repeat 305..328 CDD:275380 7/22 (32%)
leucine-rich repeat 329..352 CDD:275380 7/22 (32%)
LRR_8 352..416 CDD:290566 21/73 (29%)
leucine-rich repeat 353..376 CDD:275380 9/22 (41%)
LRRCT 414..>450 CDD:214507 11/45 (24%)
LRIT3NP_940908.3 LRR 1 56..79 5/25 (20%)
leucine-rich repeat 59..82 CDD:275378 5/25 (20%)
LRR_8 61..117 CDD:290566 18/58 (31%)
LRR 2 80..103 7/22 (32%)
leucine-rich repeat 83..106 CDD:275378 7/22 (32%)
LRR 3 104..128 8/23 (35%)
LRR_8 105..165 CDD:290566 18/59 (31%)
LRR_4 105..146 CDD:289563 13/40 (33%)
leucine-rich repeat 107..130 CDD:275378 7/22 (32%)
LRR 4 129..151 8/21 (38%)
LRR_4 131..170 CDD:289563 14/39 (36%)
leucine-rich repeat 131..154 CDD:275378 9/22 (41%)
LRR 5 152..175 6/23 (26%)
leucine-rich repeat 155..168 CDD:275378 3/12 (25%)
Ig 267..345 CDD:299845 3/4 (75%)
IG_like 267..345 CDD:214653 3/4 (75%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 351..375
FN3 486..550 CDD:214495
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165141315
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.930

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