DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Con and CG8852

DIOPT Version :9

Sequence 1:	NP_001246635.1	Gene:	Con / 38590	FlyBaseID:	FBgn0005775	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_608790.2	Gene:	CG8852 / 33577	FlyBaseID:	FBgn0031548	Length:	663	Species:	Drosophila melanogaster

Alignment Length:	756	Identity:	141/756 - (18%)
Similarity:	238/756 - (31%)	Gaps:	255/756 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 SLLLIGACLVTPTEGRAKDDRRTRGRGSSSGVLSSSSSSSNNMNNGYYS-GSSSTAGSSSGYVFT 87
            |:.|..||::..|..:.....|::........:..|.:||..||  |:. |:...||
  Fly    39 SISLPPACVIRATLYKTSSSERSQNDFGLPLAIDCSENSSMGMN--YFDLGAQRVAG-------- 93

  Fly    88 SSSAVNSGSTGYSGPMDSTGFCTRRRDMKLMCYCTPDENHVPVQKAECWVFSEGLHQNDTTWTRF 152
                                    :|.:.|..:.||     |:     .:.|.||...|..
  Fly    94 ------------------------KRHVSLDGFQTP-----PL-----GISSYGLEYLDNC---- 120

  Fly   153 YQQKRLRELKFVIQNNARLDYIPTMIIEPLKNLSSIVIEYSQVEIVKSYAFANLPFLERIILNNN 217
            ...:.:...:||.....:|.....:|    .||:::...|:::..:......:||.|:.:.|..|
  Fly   121 VDLESVEIQRFVGDATLKLSCGGALI----PNLTAVSFRYNELGTLSGETIQDLPHLKILHLQQN 181

  Fly   218 HIMALDQDAFANHIRLRELNLEH------------NQIFEMDRYAFRNLPLCERLFL-------- 262
            .:..|:.  |..|..|.||.::.            ||:.|:.|.:.||:...|..||
  Fly   182 SLRYLEY--FKEHSDLEELLIQDERDLVLRFNEILNQLPELRRLSLRNVEKIEDQFLRILPENLT 244

  Fly   263 ----NNNNIST----LHEGLFADMARLT--------------------FLNLAHNQINVLTSEIF 299
                .|..|..    |.||: |.:..:|                    :|||:.|.|:.|.....
  Fly   245 DLIIENTPIQPGVLYLTEGV-AKLVNVTITNCQLKGFALQPAHNLDIMYLNLSGNAISSLNISFE 308

  Fly   300 RGLGNLNVLKLTRNNLNFIGDTVFAELWSLSELELDDNRIERISERALDGLN--TLKTLNLRNNL 362
            .|...|..|.|:||.|..:..|.|....||..|.|.:|....:|...|..::  ::..::||:|.
  Fly   309 SGPSTLLTLDLSRNRLEHLNFTWFYRTTSLRSLHLQENHFHSLSLFQLGFISSASIHHIDLRSNE 373

  Fly   363 LKKIDNGLLRGTPALLSINVQANKLETLTFYTFQPIMDNLVNSTSELLVSDNKFICDCRLQW--- 424
            |..     .|.|             |.....::.|.:        .:.:.||.:.|    ||
  Fly   374 LMS-----FRDT-------------ENADLPSWNPQL--------RISIDDNPWSC----QWMLN 408

  Fly   425 ----------IFELKNRTRHLQLRDSLEDLHCTLQEPKLSHFVDPVPPTILDVL----------- 468
                      :|:......|:    ::..|.||.|||....     ||.:..::
  Fly   409 FSHMQPQLFRLFQYSKYISHI----NINGLSCTPQEPPSEE-----PPKVRRIMHVRINGTDSSI 464

  Fly   469 -------NIGGFTAIGSNSASMGGVGNSV---------VGSSYSGLTM-----DDSRKHLG--SR 510
                   |:..||.:..|...:.....|:         :|.::..|.:     .:...||.  :.
  Fly   465 PVPHPHGNVSSFTVLYGNPVELHRSQRSLALIIVFMLPLGIAFLFLLLYLYLHCERLFHLSYYAS 529

  Fly   511 SRQALRGQRQFASSAENVVESKMRRRRKRQEEVKEKDLAAVAPAHKRYDYYDDNNGGMSLGHGLD 575
            ......|::  :||....|:                        |.....|...|||.|.  .:|
  Fly   530 GLPCFGGEK--SSSGPRFVD------------------------HVDIVRYPIANGGSSC--PVD 566

  Fly   576 LDDNLSLHKQGFYGAGSPV---VGHNDVDVLMTSH----------------------SASGDALD 615
            ::..|....:.....|:.:   .||.:.....|.|                      ..:|||.:
  Fly   567 VETELPDGYETPVSGGTSICNCTGHRESTCSRTHHVTYESLPAELPYQLYAEIKEQADENGDADE 631

  Fly   616 ILTTKNAIYIKLFLLKPEMLPCHDELSDPTELPLSRDLMDV 656
            :|.....          ...|.:|.||...|:|...:|.|:
  Fly   632 VLAVTTG----------PTAPIYDHLSFVEEMPKLDELRDI 662

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Con	NP_001246635.1	LRR_RI	<147..291	CDD:238064	38/191 (20%)
		LRR_8	183..243	CDD:290566	15/71 (21%)
		leucine-rich repeat	185..208	CDD:275380	3/22 (14%)
		leucine-rich repeat	209..232	CDD:275380	6/22 (27%)
		LRR_RI	<225..416	CDD:238064	53/240 (22%)
		LRR_8	232..291	CDD:290566	23/106 (22%)
		leucine-rich repeat	233..256	CDD:275380	9/34 (26%)
		leucine-rich repeat	257..280	CDD:275380	9/38 (24%)
		leucine-rich repeat	281..304	CDD:275380	8/42 (19%)
		LRR_8	304..363	CDD:290566	18/60 (30%)
		leucine-rich repeat	305..328	CDD:275380	8/22 (36%)
		leucine-rich repeat	329..352	CDD:275380	6/24 (25%)
		LRR_8	352..416	CDD:290566	10/63 (16%)
		leucine-rich repeat	353..376	CDD:275380	6/22 (27%)
		LRRCT	414..>450	CDD:214507	9/48 (19%)
CG8852	NP_608790.2	LRR_RI	114..348	CDD:238064	56/244 (23%)
		LRR_8	147..213	CDD:290566	14/67 (21%)
		leucine-rich repeat	149..172	CDD:275380	3/22 (14%)
		leucine-rich repeat	173..194	CDD:275380	6/22 (27%)
		leucine-rich repeat	220..242	CDD:275380	6/21 (29%)
		leucine-rich repeat	243..266	CDD:275380	5/23 (22%)
		leucine-rich repeat	267..287	CDD:275380	1/19 (5%)
		leucine-rich repeat	288..313	CDD:275380	7/24 (29%)
		LRR_8	291..348	CDD:290566	20/56 (36%)
		leucine-rich repeat	314..337	CDD:275380	8/22 (36%)
		leucine-rich repeat	364..387	CDD:275378	7/40 (18%)
		leucine-rich repeat	392..403	CDD:275378	2/18 (11%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438698
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930