DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Con and Lgr6

DIOPT Version :9

Sequence 1:	NP_001246635.1	Gene:	Con / 38590	FlyBaseID:	FBgn0005775	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_001028581.1	Gene:	Lgr6 / 329252	MGIID:	2441805	Length:	967	Species:	Mus musculus

Alignment Length:	428	Identity:	107/428 - (25%)
Similarity:	174/428 - (40%)	Gaps:	79/428 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 SAVNSGSTGYSGPMDSTGFCTRRRDMKLMCYCTPDENHVPVQKAECWVFSE-------------- 140
            ::..:||....||        .|......|:|..|.   .:..|:|   ||
Mouse    18 ASARAGSDPQPGP--------GRPACPAPCHCQEDG---IMLSADC---SELGLSVVPADLDPLT 68

  Fly   141 ---GLHQNDTTWTR---FYQQKRLRELKFVIQNNARLDYIPTMIIEPLKNLSSIVIEYSQVEIVK 199
               .|..|:.|..:   |:..:.|.||:.   :...|.:||......|.:|..::::.:|:..:.
Mouse    69 AYLDLSMNNLTELQPGLFHHLRFLEELRL---SGNHLSHIPGQAFSGLHSLKILMLQSNQLRGIP 130

  Fly   200 SYAFANLPFLERIILNNNHIMALDQDAFANHIRLRELNLEHNQIFEMDRYAFRNLPLCERLFLNN 264
            :.|...||.|:.:.|:.|.|..:.:.:|.....||.|.|:.|.:.|:...|..|||..:.:.|..
Mouse   131 AEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLAL 195

  Fly   265 NNISTLHEGLFADMARLTFLNLAHNQINVLTSEIFRGLGNLNVLKLTRNNLNFIGDTVFAELWSL 329
            |:|..:.:..|.::..|..|:|.:|:|..:.:..|.||.||..|.|..|.|... ......|..|
Mouse   196 NHIRHIPDYAFQNLTSLVVLHLHNNRIQHVGTHSFEGLHNLETLDLNYNELQEF-PLAIRTLGRL 259

  Fly   330 SELELDDNRIERISERALDGLNTLKTLNLRNNLLKKIDNGLLRGTPALLSINVQANKLETLTFYT 394
            .||...:|.|:.|.|:|..|...|:|::..:|.::.:.....:          ..:||.||:...
Mouse   260 QELGFHNNNIKAIPEKAFMGSPLLQTIHFYDNPIQFVGRSAFQ----------YLSKLHTLSLNG 314

  Fly   395 FQPIMD--NLVNSTS-ELLVSDNKFI-------CD--CRLQWIFELKNRTRHLQLRDSLEDLH-C 446
            ...|.:  :|..:|| |:|......|       |.  .||: |.||.    |.|: :.|..|| |
Mouse   315 ATDIQEFPDLKGTTSLEILTLTRAGIRLLPPGVCQQLPRLR-ILELS----HNQI-EELPSLHRC 373

  Fly   447 -TLQEPKLSHFVDPVPPTILDVLNIGG--FTAIGSNSA 481
             .|:|..|.|         ..:..||.  |:.:||..|
Mouse   374 QKLEEIGLRH---------NRIKEIGADTFSQLGSLQA 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Con	NP_001246635.1	LRR_RI	<147..291	CDD:238064	37/146 (25%)
		LRR_8	183..243	CDD:290566	15/59 (25%)
		leucine-rich repeat	185..208	CDD:275380	4/22 (18%)
		leucine-rich repeat	209..232	CDD:275380	5/22 (23%)
		LRR_RI	<225..416	CDD:238064	52/193 (27%)
		LRR_8	232..291	CDD:290566	18/58 (31%)
		leucine-rich repeat	233..256	CDD:275380	9/22 (41%)
		leucine-rich repeat	257..280	CDD:275380	4/22 (18%)
		leucine-rich repeat	281..304	CDD:275380	8/22 (36%)
		LRR_8	304..363	CDD:290566	19/58 (33%)
		leucine-rich repeat	305..328	CDD:275380	6/22 (27%)
		leucine-rich repeat	329..352	CDD:275380	9/22 (41%)
		LRR_8	352..416	CDD:290566	13/66 (20%)
		leucine-rich repeat	353..376	CDD:275380	3/22 (14%)
		LRRCT	414..>450	CDD:214507	14/46 (30%)
Lgr6	NP_001028581.1	LRRNT	34..68	CDD:214470	7/39 (18%)
		LRR_4	70..107	CDD:289563	9/39 (23%)
		leucine-rich repeat	70..91	CDD:275380	4/20 (20%)
		LRR 1	91..112		6/23 (26%)
		LRR_8	92..150	CDD:290566	15/60 (25%)
		LRR_4	92..131	CDD:289563	9/41 (22%)
		leucine-rich repeat	92..115	CDD:275380	7/25 (28%)
		LRR 2	115..136		3/20 (15%)
		leucine-rich repeat	116..139	CDD:275380	4/22 (18%)
		LRR_8	138..198	CDD:290566	18/59 (31%)
		LRR 3	139..160		5/20 (25%)
		leucine-rich repeat	140..163	CDD:275380	5/22 (23%)
		LRR_RI	143..392	CDD:238064	74/274 (27%)
		LRR 4	163..186		8/22 (36%)
		leucine-rich repeat	164..187	CDD:275380	9/22 (41%)
		LRR_8	186..246	CDD:290566	18/59 (31%)
		LRR 5	187..208		4/20 (20%)
		leucine-rich repeat	188..211	CDD:275380	4/22 (18%)
		LRR 6	211..232		6/20 (30%)
		leucine-rich repeat	212..235	CDD:275380	8/22 (36%)
		LRR 7	235..256		6/21 (29%)
		leucine-rich repeat	236..258	CDD:275380	6/22 (27%)
		LRR_8	258..314	CDD:290566	16/65 (25%)
		LRR 8	258..279		8/20 (40%)
		leucine-rich repeat	259..282	CDD:275380	9/22 (41%)
		LRR 9	282..302		3/19 (16%)
		leucine-rich repeat	283..304	CDD:275380	3/30 (10%)
		LRR 10	303..325		5/21 (24%)
		LRR_8	305..364	CDD:290566	18/63 (29%)
		leucine-rich repeat	307..348	CDD:275380	10/40 (25%)
		LRR 11	329..350		5/20 (25%)
		LRR 12	353..374		10/26 (38%)
		leucine-rich repeat	354..375	CDD:275380	10/26 (38%)
		LRR_8	375..434	CDD:290566	10/37 (27%)
		LRR 13	375..396		7/29 (24%)
		leucine-rich repeat	376..399	CDD:275380	7/31 (23%)
		LRR 14	399..420		2/4 (50%)
		leucine-rich repeat	400..421	CDD:275380	1/3 (33%)
		LRR 15	423..443
		leucine-rich repeat	424..444	CDD:275380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831244
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840