DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Con and Lrig1

DIOPT Version :9

Sequence 1:	NP_001246635.1	Gene:	Con / 38590	FlyBaseID:	FBgn0005775	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	XP_232237.6	Gene:	Lrig1 / 312574	RGDID:	1306788	Length:	1096	Species:	Rattus norvegicus

Alignment Length:	488	Identity:	112/488 - (22%)
Similarity:	193/488 - (39%)	Gaps:	120/488 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LADSAICFLLLSLLLI------------------GACLVTPTEGRAKDDRRTRGRGSS------- 52
            ||...:.:|||.|||:                  .||..      |.|.....|||.:
  Rat    14 LAPRLLLWLLLLLLLLLQGPESAVAQAGPRAPCAAACTC------AGDSLDCSGRGLATLPRDMP 72

  Fly    53 -------------SGVLSSSSSSSNNMNNGYYSGSSSTA----GSSSGYV---FTSSSAVNSGST 97
                         |.:..::.....|:...|.:.:..||    |::|.:|   |...:.:.|
  Rat    73 SWTRSLNLSYNRLSEIDPAAFEDLTNLQEVYLNSNELTAVPSLGAASMHVVSLFLQHNKILS--- 134

  Fly    98 GYSGPMDSTGFCTRRRDMKLMCYCTPD-----ENHVPVQKAECWVFSEGLHQNDTTWTRFYQQKR 157
                 :|.:         :|..|.:.:     .|::...::.|  |..||              |
  Rat   135 -----VDGS---------QLKSYLSLEVLDLSSNNITEIRSSC--FPNGL--------------R 169

  Fly   158 LRELKF------VIQNNA----------------RLDYIPTMIIEPLKNLSSIVIEYSQVEIVKS 200
            :|||..      ::::.|                |:..:|....: |..|:.:.:..:::.:::.
  Rat   170 VRELNLASNRISILESGAFDGLSRSLLTLRLSKNRITQLPVKAFK-LPRLTQLDLNRNRIRLIEG 233

  Fly   201 YAFANLPFLERIILNNNHIMALDQDAFANHIRLRELNLEHNQIFEMDRYAFRNLPLCERLFLNNN 265
            ..|..|..||.:.|..|::..|...||....::..|:||:|.:.|::..:...|....:|.|:||
  Rat   234 LTFQGLDSLEVLKLQRNNLSKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNN 298

  Fly   266 NISTLHEGLFADMARLTFLNLAHNQINVLTSEIFRGLGNLNVLKLTRNNLNFIGDTVFAELWSLS 330
            :||.:....::...:|..|.|:.|.:..|..|....|..|::|:|:.|.::.|.:..|..|.||.
  Rat   299 SISRIQRDGWSFCQKLHELILSFNNLTRLDEESLAELSGLSILRLSHNAISHIAEGAFKGLKSLR 363

  Fly   331 ELELDDNRIERISE---RALDGLNTLKTLNLRNNLLKKIDNGLLRGTPALLSINVQANKLETLTF 392
            .||||.|.|....|   .|..||:.|..|.|..|.:|.:......|...|..:|:..|.:.::.|
  Rat   364 VLELDHNEISGTIEDTSGAFMGLDNLSKLTLFGNKIKSVAKRAFSGLENLEHLNLGENAIRSIQF 428

  Fly   393 YTFQPIMDNLVNSTSELLVSDNKFICDCRLQWI 425
            ..|.. |.||    .||.:|...|:|||:|:|:
  Rat   429 DAFAK-MKNL----KELYISSESFLCDCQLKWL 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Con	NP_001246635.1	LRR_RI	<147..291	CDD:238064	34/165 (21%)
		LRR_8	183..243	CDD:290566	14/59 (24%)
		leucine-rich repeat	185..208	CDD:275380	3/22 (14%)
		leucine-rich repeat	209..232	CDD:275380	7/22 (32%)
		LRR_RI	<225..416	CDD:238064	57/193 (30%)
		LRR_8	232..291	CDD:290566	16/58 (28%)
		leucine-rich repeat	233..256	CDD:275380	6/22 (27%)
		leucine-rich repeat	257..280	CDD:275380	6/22 (27%)
		leucine-rich repeat	281..304	CDD:275380	7/22 (32%)
		LRR_8	304..363	CDD:290566	23/61 (38%)
		leucine-rich repeat	305..328	CDD:275380	7/22 (32%)
		leucine-rich repeat	329..352	CDD:275380	11/25 (44%)
		LRR_8	352..416	CDD:290566	17/63 (27%)
		leucine-rich repeat	353..376	CDD:275380	6/22 (27%)
		LRRCT	414..>450	CDD:214507	6/12 (50%)
Lrig1	XP_232237.6	LRR_8	76..132	CDD:290566	9/55 (16%)
		LRR_4	76..115	CDD:289563	5/38 (13%)
		leucine-rich repeat	76..98	CDD:275380	1/21 (5%)
		leucine-rich repeat	99..114	CDD:275380	3/14 (21%)
		leucine-rich repeat	122..145	CDD:275380	6/39 (15%)
		LRR_RI	138..421	CDD:238064	71/308 (23%)
		LRR_8	145..228	CDD:290566	14/99 (14%)
		leucine-rich repeat	146..169	CDD:275380	5/38 (13%)
		leucine-rich repeat	170..193	CDD:275380	4/22 (18%)
		leucine-rich repeat	194..217	CDD:275380	3/23 (13%)
		LRR_8	216..276	CDD:290566	14/59 (24%)
		leucine-rich repeat	218..241	CDD:275380	3/22 (14%)
		leucine-rich repeat	242..265	CDD:275380	7/22 (32%)
		LRR_8	264..324	CDD:290566	16/59 (27%)
		leucine-rich repeat	266..289	CDD:275380	6/22 (27%)
		leucine-rich repeat	290..313	CDD:275380	6/22 (27%)
		LRR_8	313..372	CDD:290566	21/58 (36%)
		leucine-rich repeat	314..337	CDD:275380	7/22 (32%)
		leucine-rich repeat	338..361	CDD:275380	7/22 (32%)
		leucine-rich repeat	362..386	CDD:275380	9/23 (39%)
		LRR_8	388..444	CDD:290566	16/60 (27%)
		leucine-rich repeat	389..412	CDD:275380	6/22 (27%)
		LRR_4	411..>444	CDD:289563	10/37 (27%)
		leucine-rich repeat	413..434	CDD:275380	5/21 (24%)
		LRRCT	447..495	CDD:214507	6/10 (60%)
		I-set	500..600	CDD:254352
		Ig	517..591	CDD:143165
		I-set	604..694	CDD:254352
		Ig_1	621..695	CDD:143240
		I-set	698..785	CDD:254352
		IGc2	712..775	CDD:197706
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910