DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Con and Lgr4

DIOPT Version :9

Sequence 1:	NP_001246635.1	Gene:	Con / 38590	FlyBaseID:	FBgn0005775	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_775450.2	Gene:	Lgr4 / 286994	RGDID:	628615	Length:	951	Species:	Rattus norvegicus

Alignment Length:	572	Identity:	137/572 - (23%)
Similarity:	216/572 - (37%)	Gaps:	126/572 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 GSTGYSGPMDSTGFCTRRRDMKLMCYCTPDENHVPVQKAEC-----WVFSEGL---------HQN 145
            ||.|.||.  :...|.      ..|.|..|      ::.:|     ....|||         ..|
  Rat    17 GSAGPSGA--APPLCA------APCSCDGD------RRVDCSGKGLTAVPEGLSAFTQALDISMN 67

  Fly   146 DTTW---TRFYQQKRLRELKFVIQNNARLDYIPTMIIEPLKNLSSIVIEYSQVEIVKSYAFANLP 207
            :.|.   ..|.....|.||:....:   |.:|....:..||.|..:.::.:|:..|.|.|...|.
  Rat    68 NITQLPEDAFKSFPFLEELQLAGND---LSFIHPKALSGLKELKVLTLQNNQLRTVPSEAIHGLS 129

  Fly   208 FLERIILNNNHIMALDQDAFANHIRLRELNLEHNQIFEMDRYAFRNLPLCERLFLNNNNISTLHE 272
            .|:.:.|:.|||.::.:|:|...::||.|.|:.|.:.|:......|||..:.|.|..||||::.:
  Rat   130 ALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVRPLSNLPTLQALTLALNNISSIPD 194

  Fly   273 GLFADMARLTFLNLAHNQINVLTSEIFRGLGNLNVLKLTRNNLNFIGDTVFAELWSLSELELDDN 337
            ..|.:::.|..|:|.:|:|..|:...|.||.||..|.|..|||:.....:.| |.||.||....|
  Rat   195 FAFTNLSSLVVLHLHNNKIKSLSQHCFDGLDNLETLDLNYNNLDEFPQAIKA-LPSLKELGFHSN 258

  Fly   338 RIERISERALDGLNTLKTLNLRNNLLKKIDNGLLRGTPALLSINVQANKLE-------------- 388
            .|..|.:.|..|...|:|::|.:|.|..:.|........|.|:.::...|.
  Rat   259 SISVIPDGAFGGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASLVQWFPNLTGTVHLES 323

  Fly   389 -TLTFYTFQPIMDNLVNSTSELLVSDNKFICDCRLQWIFELKNRTRHLQLRD---SLEDLHCTLQ 449
             |||......|.|:|..:...|...|..:             |..|.|...:   :||::  :||
  Rat   324 LTLTGTKISSIPDDLCQNQKMLRTLDLSY-------------NNIRDLPSFNGCRALEEI--SLQ 373

  Fly   450 EPKLS-----HFVDPVPPTILDV-------LNIGGFTAIGSNSASMGGVGNSVVGSSYSGLTMDD 502
            ..::|     .|.......|||:       ::.|.|       |.:|.:.|           :|.
  Rat   374 RNQISLIKENTFQGLTSLRILDLSRNLIREIHSGAF-------AKLGTITN-----------LDV 420

  Fly   503 SRKHLGSRSRQALRGQRQFASSAENVVESKMRRRRKRQEEVKEKDLAAVAPAHKRYDYYDDNNGG 567
            |...|.|...:.|.|..|.          |:....|.::.:..:|.|.:......|.|......|
  Rat   421 SFNELTSFPTEGLNGLNQL----------KLVGNFKLKDALAARDFANLRSLSVPYAYQCCAFWG 475

  Fly   568 MSLGHGLDLDDNLSLHKQGFYGAGSPVVGHNDVDVLMTSHSASGDALDILTT 619
            ......|:.:||            || ..|:     :|....:.||.::.:|
  Rat   476 CDSYANLNTEDN------------SP-QEHS-----VTKEKGATDAANVTST 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Con	NP_001246635.1	LRR_RI	<147..291	CDD:238064	42/146 (29%)
		LRR_8	183..243	CDD:290566	19/59 (32%)
		leucine-rich repeat	185..208	CDD:275380	6/22 (27%)
		leucine-rich repeat	209..232	CDD:275380	7/22 (32%)
		LRR_RI	<225..416	CDD:238064	62/205 (30%)
		LRR_8	232..291	CDD:290566	20/58 (34%)
		leucine-rich repeat	233..256	CDD:275380	8/22 (36%)
		leucine-rich repeat	257..280	CDD:275380	7/22 (32%)
		leucine-rich repeat	281..304	CDD:275380	9/22 (41%)
		LRR_8	304..363	CDD:290566	22/58 (38%)
		leucine-rich repeat	305..328	CDD:275380	8/22 (36%)
		leucine-rich repeat	329..352	CDD:275380	8/22 (36%)
		LRR_8	352..416	CDD:290566	17/78 (22%)
		leucine-rich repeat	353..376	CDD:275380	6/22 (27%)
		LRRCT	414..>450	CDD:214507	6/38 (16%)
Lgr4	NP_775450.2	LRRNT	29..61	CDD:214470	8/43 (19%)
		LRR 1	58..79		3/20 (15%)
		leucine-rich repeat	59..82	CDD:275380	3/22 (14%)
		LRR	<62..301	CDD:227223	73/242 (30%)
		LRR 2	82..103		5/23 (22%)
		leucine-rich repeat	83..106	CDD:275380	6/25 (24%)
		LRR 3	106..127		5/20 (25%)
		leucine-rich repeat	107..130	CDD:275380	6/22 (27%)
		LRR 4	130..151		7/20 (35%)
		leucine-rich repeat	131..154	CDD:275380	7/22 (32%)
		LRR 5	154..177		7/22 (32%)
		leucine-rich repeat	155..178	CDD:275380	8/22 (36%)
		LRR 6	178..199		7/20 (35%)
		leucine-rich repeat	179..202	CDD:275380	7/22 (32%)
		LRR 7	202..223		7/20 (35%)
		leucine-rich repeat	203..226	CDD:275380	9/22 (41%)
		LRR 8	226..247		8/21 (38%)
		leucine-rich repeat	227..249	CDD:275380	8/22 (36%)
		LRR 9	249..270		8/20 (40%)
		leucine-rich repeat	250..273	CDD:275380	8/22 (36%)
		LRR 10	273..294		6/20 (30%)
		leucine-rich repeat	274..295	CDD:275380	6/20 (30%)
		LRR	275..>465	CDD:227223	44/232 (19%)
		LRR 11	320..341		6/20 (30%)
		leucine-rich repeat	321..344	CDD:275378	6/22 (27%)
		LRR 12	344..365		5/33 (15%)
		LRR_8	345..401	CDD:404697	14/70 (20%)
		leucine-rich repeat	345..366	CDD:275378	5/33 (15%)
		LRR 13	366..387		6/22 (27%)
		leucine-rich repeat	367..390	CDD:275378	6/24 (25%)
		LRR 14	390..411		5/27 (19%)
		leucine-rich repeat	391..414	CDD:275378	6/29 (21%)
		LRR 15	414..435		6/31 (19%)
		leucine-rich repeat	415..427	CDD:275378	4/22 (18%)
		leucine-rich repeat	436..461	CDD:275380	5/34 (15%)
		7tmA_LGR4	539..812	CDD:320483
		TM helix 1	541..565	CDD:320483
		TM helix 2	574..595	CDD:320483
		TM helix 3	619..641	CDD:320483
		TM helix 4	664..680	CDD:320483
		TM helix 5	704..727	CDD:320483
		TM helix 6	746..768	CDD:320483
		TM helix 7	780..805	CDD:320483
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334989
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840