Protein Alignment Con and GP5

DIOPT Version :10

• Sequence 1: NP_523930.3
• Gene: Con / 38590
• FlyBaseID: FBgn0005775
• Length: 691
• Species: Drosophila melanogaster
• Sequence 2: NP_004479.1
• Gene: GP5 / 2814
• HGNCID: 4443
• Length: 560
• Species: Homo sapiens
• Alignment Length: 335
• Identity: 88/335 - (26%)
• Similarity: 140/335 - (41%)
• Gaps: 48/335 - (14%)

  Fly   141 GLHQNDTTWTRFYQQKRLRELKFVIQNNARLDYIPTMIIEPLKNLSSIVIEYSQVEIVKSYAFAN 205
            |:.||     .|.:...|:||..   |..:||::|..:...|:||..:.:..:.:..:.......
Human   136 GIDQN-----MFQKLVNLQELAL---NQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGA 192

  Fly   206 LPFLERIILNNNHIMALDQDAFANHIRLRELNLEHNQIFEMDRYAFRNLPLCERLFLNNNNISTL 270
            ...|||::|::|.:::||.....:...|.||....|.|..:...||..||....|.|:.|:::.|
Human   193 QAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAFL 257

  Fly   271 HEGLFADMARLTFLNLAHNQINVLTSEIFRGLGNLNVLKLTR--------------NNLNFIGDT 321
            ...||.....||.|.|..|.:..|...:|..:|.|..|.|.|              :.|.::|.|
Human   258 PSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQLRTLPAAAFRNLSRLRYLGVT 322

  Fly   322 V-----------FAELWSLSELELDDNRIERISERALDGLNTLKTLNLRNNLLKKIDNGLLRGTP 375
            :           |..|..|..|.|..|.:..:.:..|.||..|:.::||.|.|:.:...|.|...
Human   323 LSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGKLRQVSLRRNRLRALPRALFRNLS 387

  Fly   376 ALLSINVQANKLETLTFYTFQPIMDNLVNSTSELLVSDNKFICDCR----LQWIFELKNRTRHLQ 436
            :|.|:.:..|:||||....|     ..:...:|:|:..|.:.|||.    |.|:      .:||.
Human   388 SLESVQLDHNQLETLPGDVF-----GALPRLTEVLLGHNSWRCDCGLGPFLGWL------RQHLG 441

  Fly   437 LRDSLEDLHC 446
            |....|...|
Human   442 LVGGEEPPRC 451

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Con	NP_523930.3	LRR	<157..459	CDD:443914	84/319 (26%)
		leucine-rich repeat	185..208	CDD:275380	1/22 (5%)
		leucine-rich repeat	209..232	CDD:275380	7/22 (32%)
		leucine-rich repeat	233..256	CDD:275380	8/22 (36%)
		leucine-rich repeat	257..280	CDD:275380	6/22 (27%)
		leucine-rich repeat	281..304	CDD:275380	7/22 (32%)
		leucine-rich repeat	305..328	CDD:275380	9/47 (19%)
		leucine-rich repeat	329..352	CDD:275380	7/22 (32%)
		leucine-rich repeat	353..376	CDD:275380	7/22 (32%)
GP5	NP_004479.1	LRR	<44..>299	CDD:443914	47/170 (28%)
		LRR 1	75..96
		leucine-rich repeat	76..99	CDD:275380
		LRR 2	99..120
		leucine-rich repeat	100..123	CDD:275380
		LRR 3	123..144		4/12 (33%)
		leucine-rich repeat	124..147	CDD:275380	4/15 (27%)
		LRR 4	147..168		7/23 (30%)
		leucine-rich repeat	148..171	CDD:275380	8/25 (32%)
		LRR 5	171..193		2/21 (10%)
		leucine-rich repeat	172..195	CDD:275380	1/22 (5%)
		LRR 6	195..216		7/20 (35%)
		leucine-rich repeat	196..219	CDD:275380	7/22 (32%)
		LRR 7	219..240		7/20 (35%)
		leucine-rich repeat	220..243	CDD:275380	8/22 (36%)
		LRR 8	243..264		6/20 (30%)
		leucine-rich repeat	244..267	CDD:275380	6/22 (27%)
		LRR 9	267..288		7/20 (35%)
		leucine-rich repeat	268..291	CDD:275380	7/22 (32%)
		LRR_8	291..351	CDD:404697	13/59 (22%)
		LRR 10	291..312		4/20 (20%)
		leucine-rich repeat	292..315	CDD:275380	4/22 (18%)
		leucine-rich repeat	316..338	CDD:275380	4/21 (19%)
		LRR_8	340..399	CDD:404697	17/58 (29%)
		LRR 11	340..361		5/20 (25%)
		leucine-rich repeat	341..364	CDD:275380	7/22 (32%)
		LRR 12	364..385		6/20 (30%)
		leucine-rich repeat	365..388	CDD:275380	7/22 (32%)
		LRR 13	388..409		8/25 (32%)
		leucine-rich repeat	389..410	CDD:275380	8/25 (32%)
		LRRCT	421..472	CDD:214507	11/37 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	469..498