DRSC/TRiP Functional Genomics Resources

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Protein Alignment Con and LRRTM2

DIOPT Version :9

Sequence 1:NP_001246635.1 Gene:Con / 38590 FlyBaseID:FBgn0005775 Length:691 Species:Drosophila melanogaster
Sequence 2:NP_056379.1 Gene:LRRTM2 / 26045 HGNCID:19409 Length:516 Species:Homo sapiens


Alignment Length:350 Identity:92/350 - (26%)
Similarity:150/350 - (42%) Gaps:75/350 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   214 LNNNHIMALDQDAFANHIRLRELNLEHNQIFEMDRYAFRNLPLCERLFLNNNNISTLHEGLFADM 278
            |.:|||..|::|.||:..:|..|:|:||||..:...||:.|...:.|.|::|.|..|....|..:
Human    68 LRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLPNTTFTQL 132

  Fly   279 ARLTFLNLAHNQINVLTSEIFRGLGNLNVLKLTRNNLNFIGDTVFAELWSLSELELDDNRIERIS 343
            ..|..|:|:.||::.|..|:|.||..|..|.|..|:|..|...:|.:..||..|:|..||:..::
Human   133 INLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRLRSLA 197

  Fly   344 ERALDGLNTLKTLNLRNNLLKKIDNGLLRGTPALLSINVQANKLETLT----------------- 391
            .....||..|:.|:|.:|.|.||:........:|.::.:|.||:..||                 
Human   198 RNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNLTCGMEWTWGTLEKLDLTG 262

  Fly   392 ----------FYTFQP----IMDN---------LVNSTSELL---VSDNKFICDCRL----QWIF 426
                      |.|...    :|||         ::||...|.   :|.|.:.|..|:    .|:.
Human   263 NEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSLTTVGLSGNLWECSARICALASWLG 327

  Fly   427 ELKNRTRHLQLRDSLEDLHCTLQEPKLSHFVDPVPPTILDVLNIGGFTAIGSNSASMGGVGNSVV 491
            ..:.|..|..|..|          |..:...|     |||.::  ||....:.|.::     :|:
Human   328 SFQGRWEHSILCHS----------PDHTQGED-----ILDAVH--GFQLCWNLSTTV-----TVM 370

  Fly   492 GSSYSGLTMDDSRK------HLGSR 510
            .::|...|.:.:::      |:|.:
Human   371 ATTYRDPTTEYTKRISSSSYHVGDK 395

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ConNP_001246635.1 LRR_RI <147..291 CDD:238064 28/76 (37%)
LRR_8 183..243 CDD:290566 13/28 (46%)
leucine-rich repeat 185..208 CDD:275380
leucine-rich repeat 209..232 CDD:275380 8/17 (47%)
LRR_RI <225..416 CDD:238064 67/233 (29%)
LRR_8 232..291 CDD:290566 20/58 (34%)
leucine-rich repeat 233..256 CDD:275380 10/22 (45%)
leucine-rich repeat 257..280 CDD:275380 6/22 (27%)
leucine-rich repeat 281..304 CDD:275380 10/22 (45%)
LRR_8 304..363 CDD:290566 19/58 (33%)
leucine-rich repeat 305..328 CDD:275380 7/22 (32%)
leucine-rich repeat 329..352 CDD:275380 7/22 (32%)
LRR_8 352..416 CDD:290566 23/106 (22%)
leucine-rich repeat 353..376 CDD:275380 7/22 (32%)
LRRCT 414..>450 CDD:214507 8/39 (21%)
LRRTM2NP_056379.1 LRR 1 63..83 7/14 (50%)
LRR <65..312 CDD:227223 71/243 (29%)
leucine-rich repeat 66..86 CDD:275380 8/17 (47%)
LRR 2 86..107 9/20 (45%)
leucine-rich repeat 87..110 CDD:275380 10/22 (45%)
LRR 3 110..131 6/20 (30%)
leucine-rich repeat 111..134 CDD:275380 6/22 (27%)
LRR 4 134..155 8/20 (40%)
leucine-rich repeat 135..158 CDD:275380 10/22 (45%)
LRR 5 158..179 7/20 (35%)
leucine-rich repeat 159..182 CDD:275380 7/22 (32%)
LRR 6 182..203 6/20 (30%)
leucine-rich repeat 183..206 CDD:275380 7/22 (32%)
LRR 7 206..227 7/20 (35%)
leucine-rich repeat 207..230 CDD:275380 7/22 (32%)
LRR 8 230..251 6/20 (30%)
leucine-rich repeat 231..254 CDD:275380 6/22 (27%)
LRR 9 254..275 1/20 (5%)
leucine-rich repeat 255..278 CDD:275380 2/22 (9%)
LRR 10 278..299 3/20 (15%)
leucine-rich repeat 279..300 CDD:275380 4/20 (20%)
PCC 284..>351 CDD:188093 17/81 (21%)
Involved in DLG4-binding. /evidence=ECO:0000250 513..516
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165141279
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.840

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