DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Con and Lgi4

DIOPT Version :9

Sequence 1:	NP_001246635.1	Gene:	Con / 38590	FlyBaseID:	FBgn0005775	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_653139.2	Gene:	Lgi4 / 243914	MGIID:	2180197	Length:	537	Species:	Mus musculus

Alignment Length:	264	Identity:	70/264 - (26%)
Similarity:	107/264 - (40%)	Gaps:	57/264 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   281 LTFLNLAHNQINVLTSEIFRGLGNLNVLKLTRNNLNFIGDTVFAELWSLSELELDDNRIERISER 345
            |..|:|....::.|.:..|..:.:|::|..|.|..:.|....|..|..|..|.::||:|..||:.
Mouse    54 LLSLSLVRMGVSRLKAGSFLKMPSLHLLLFTSNTFSVIEGDAFIGLSYLQYLFIEDNKIGSISKN 118

  Fly   346 ALDGLNTLKTLNLRNNLLKKIDNGLLRGTPALLSINVQANKLETLTFYTFQPIMDNLVNSTSELL 410
            ||.||.:|..|:|.||.|:.:...|.||             |||||....:
Mouse   119 ALRGLRSLTHLSLANNHLEALPRFLFRG-------------LETLTHVDLR-------------- 156

  Fly   411 VSDNKFICDCRLQWIFELKNRTRHLQLRDSLEDLHC----TLQEPKLSHFVDP----VPPTILDV 467
              .|.|.||||:.|:.:...     .:..|:....|    .:.:.:|:| :||    ...|.|..
Mouse   157 --GNPFQCDCRVLWLLQWMP-----TVNASVGTGACAGPPAVAQIQLNH-LDPKKFKCRATELSW 213

  Fly   468 LNIGGFTAIGSNSASMGGVGNSVVGSSYSG----LTMDDSRKHLGSRSRQALRGQRQFASSAENV 528
            |...|.:|:...|.|..|..:.|:...::|    |..|        .|.|..|.:.:.  ||.:|
Mouse   214 LQTVGESALSVESFSYQGEPHMVLAQPFAGRCLILVWD--------YSLQRFRPEEEL--SAPSV 268

  Fly   529 VESK 532
            |..|
Mouse   269 VSCK 272

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Con	NP_001246635.1	LRR_RI	<147..291	CDD:238064	3/9 (33%)
		LRR_8	183..243	CDD:290566
		leucine-rich repeat	185..208	CDD:275380
		leucine-rich repeat	209..232	CDD:275380
		LRR_RI	<225..416	CDD:238064	38/134 (28%)
		LRR_8	232..291	CDD:290566	3/9 (33%)
		leucine-rich repeat	233..256	CDD:275380
		leucine-rich repeat	257..280	CDD:275380
		leucine-rich repeat	281..304	CDD:275380	5/22 (23%)
		LRR_8	304..363	CDD:290566	23/58 (40%)
		leucine-rich repeat	305..328	CDD:275380	7/22 (32%)
		leucine-rich repeat	329..352	CDD:275380	11/22 (50%)
		LRR_8	352..416	CDD:290566	15/63 (24%)
		leucine-rich repeat	353..376	CDD:275380	9/22 (41%)
		LRRCT	414..>450	CDD:214507	9/39 (23%)
Lgi4	NP_653139.2	LRR 1	53..74		5/19 (26%)
		leucine-rich repeat	54..77	CDD:275378	5/22 (23%)
		LRR_8	76..136	CDD:290566	23/59 (39%)
		LRR 2	77..98		6/20 (30%)
		leucine-rich repeat	78..101	CDD:275378	7/22 (32%)
		LRR 3	101..122		9/20 (45%)
		LRR_4	102..140	CDD:289563	17/37 (46%)
		leucine-rich repeat	102..125	CDD:275378	11/22 (50%)
		LRR 4	125..146		7/20 (35%)
		leucine-rich repeat	126..149	CDD:275378	10/35 (29%)
		leucine-rich repeat	150..162	CDD:275378	4/27 (15%)
		LRRCT	158..206	CDD:214507	13/53 (25%)
		EAR 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	210..252		11/49 (22%)
		EPTP	<220..251	CDD:281697	7/30 (23%)
		EAR 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	256..298		6/19 (32%)
		EAR 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	302..349
		EAR 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	351..394
		EPTP	351..392	CDD:281697
		EAR 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	396..439
		EPTP	396..438	CDD:281697
		EAR 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	441..483
		EAR 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	487..532
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831266
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X486
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.930