Protein Alignment Con and Lgi4

DIOPT Version :10

• Sequence 1: NP_523930.3
• Gene: Con / 38590
• FlyBaseID: FBgn0005775
• Length: 691
• Species: Drosophila melanogaster
• Sequence 2: NP_653139.2
• Gene: Lgi4 / 243914
• MGIID: 2180197
• Length: 537
• Species: Mus musculus
• Alignment Length: 264
• Identity: 70/264 - (26%)
• Similarity: 107/264 - (40%)
• Gaps: 57/264 - (21%)

  Fly   281 LTFLNLAHNQINVLTSEIFRGLGNLNVLKLTRNNLNFIGDTVFAELWSLSELELDDNRIERISER 345
            |..|:|....::.|.:..|..:.:|::|..|.|..:.|....|..|..|..|.::||:|..||:.
Mouse    54 LLSLSLVRMGVSRLKAGSFLKMPSLHLLLFTSNTFSVIEGDAFIGLSYLQYLFIEDNKIGSISKN 118

  Fly   346 ALDGLNTLKTLNLRNNLLKKIDNGLLRGTPALLSINVQANKLETLTFYTFQPIMDNLVNSTSELL 410
            ||.||.:|..|:|.||.|:.:...|.||             |||||....:
Mouse   119 ALRGLRSLTHLSLANNHLEALPRFLFRG-------------LETLTHVDLR-------------- 156

  Fly   411 VSDNKFICDCRLQWIFELKNRTRHLQLRDSLEDLHC----TLQEPKLSHFVDP----VPPTILDV 467
              .|.|.||||:.|:.:...     .:..|:....|    .:.:.:|:| :||    ...|.|..
Mouse   157 --GNPFQCDCRVLWLLQWMP-----TVNASVGTGACAGPPAVAQIQLNH-LDPKKFKCRATELSW 213

  Fly   468 LNIGGFTAIGSNSASMGGVGNSVVGSSYSG----LTMDDSRKHLGSRSRQALRGQRQFASSAENV 528
            |...|.:|:...|.|..|..:.|:...::|    |..|        .|.|..|.:.:.  ||.:|
Mouse   214 LQTVGESALSVESFSYQGEPHMVLAQPFAGRCLILVWD--------YSLQRFRPEEEL--SAPSV 268

  Fly   529 VESK 532
            |..|
Mouse   269 VSCK 272

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Con	NP_523930.3	LRR	<157..459	CDD:443914	48/181 (27%)
		leucine-rich repeat	185..208	CDD:275380
		leucine-rich repeat	209..232	CDD:275380
		leucine-rich repeat	233..256	CDD:275380
		leucine-rich repeat	257..280	CDD:275380
		leucine-rich repeat	281..304	CDD:275380	5/22 (23%)
		leucine-rich repeat	305..328	CDD:275380	7/22 (32%)
		leucine-rich repeat	329..352	CDD:275380	11/22 (50%)
		leucine-rich repeat	353..376	CDD:275380	9/22 (41%)
Lgi4	NP_653139.2	LRR 1	53..74		5/19 (26%)
		leucine-rich repeat	54..77	CDD:275378	5/22 (23%)
		LRR_8	76..136	CDD:404697	23/59 (39%)
		LRR 2	77..98		6/20 (30%)
		leucine-rich repeat	78..101	CDD:275378	7/22 (32%)
		LRR 3	101..122		9/20 (45%)
		leucine-rich repeat	102..125	CDD:275378	11/22 (50%)
		LRR 4	125..146		7/20 (35%)
		leucine-rich repeat	126..149	CDD:275378	10/35 (29%)
		PCC	131..>192	CDD:188093	21/94 (22%)
		leucine-rich repeat	150..162	CDD:275378	4/27 (15%)
		EAR 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00075	210..252		11/49 (22%)
		EPTP	<220..250	CDD:461033	7/29 (24%)
		EAR 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00075	256..298		6/19 (32%)
		EAR 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00075	302..349
		EAR 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00075	351..394
		EAR 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00075	396..439
		EPTP	396..437	CDD:461033
		EAR 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00075	441..483
		EPTP	441..480	CDD:461033
		EAR 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00075	487..532