DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Con and Lrit1

DIOPT Version :9

Sequence 1:NP_001246635.1 Gene:Con / 38590 FlyBaseID:FBgn0005775 Length:691 Species:Drosophila melanogaster
Sequence 2:NP_666357.2 Gene:Lrit1 / 239037 MGIID:2385320 Length:624 Species:Mus musculus


Alignment Length:254 Identity:65/254 - (25%)
Similarity:94/254 - (37%) Gaps:61/254 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   308 LKLTRNNLNFIGDTVFAELWSLSELELDDNRIERISERALDGLNTLKTLNLRNNLLKKIDNGLLR 372
            |:|.|..:..:....|..|..|.:|.|..|.:..:|...|.||..|:.|.|..|.|.......||
Mouse    64 LRLERTAIRRVPGETFRPLSRLEQLWLPYNALSELSALMLRGLRRLRELRLPGNRLVTFPWAALR 128

  Fly   373 GTPALLSINVQANKLET--------LTFYTFQPIMDN-LVNSTSELL------------------ 410
            .||.|..:::|||:|.|        |...||..:.:| |:....|||                  
Mouse   129 DTPQLQLLDLQANRLSTLPPEAAHFLENLTFLDLSNNQLMRLPEELLDVWAHLKTGPFLSGHHAR 193

  Fly   411 ----VSDNKFICDCRLQ--------WIFE----LKNRTRHLQLR-------DSLEDLHCTLQE-- 450
                :.||.::|||||.        |:..    ::.|.|....|       ..||...|...|  
Mouse   194 LILGLQDNPWVCDCRLYDLVHLLDGWVSSNLIFIEARLRCASPRSLAGVAFSQLELRKCQSPELR 258

  Fly   451 PKLSHFVDPVPPTILDVLNIGGFTAIG-------SNSASMGGVGNSVVGSSYSGLTMDD 502
            |.::..:.|:..|:|  |..|.....|       :|...:.|..:..|.|..|..|:.|
Mouse   259 PGVTSIISPLGSTVL--LRCGATGIPGPEMSWRRANGRPLNGTVHQEVSSDGSSWTLLD 315

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ConNP_001246635.1 LRR_RI <147..291 CDD:238064
LRR_8 183..243 CDD:290566
leucine-rich repeat 185..208 CDD:275380
leucine-rich repeat 209..232 CDD:275380
LRR_RI <225..416 CDD:238064 38/138 (28%)
LRR_8 232..291 CDD:290566
leucine-rich repeat 233..256 CDD:275380
leucine-rich repeat 257..280 CDD:275380
leucine-rich repeat 281..304 CDD:275380
LRR_8 304..363 CDD:290566 17/54 (31%)
leucine-rich repeat 305..328 CDD:275380 5/19 (26%)
leucine-rich repeat 329..352 CDD:275380 8/22 (36%)
LRR_8 352..416 CDD:290566 25/94 (27%)
leucine-rich repeat 353..376 CDD:275380 8/22 (36%)
LRRCT 414..>450 CDD:214507 13/54 (24%)
Lrit1NP_666357.2 LRRNT 23..61 CDD:214470
LRR 1 60..81 4/16 (25%)
LRR_8 63..143 CDD:290566 26/78 (33%)
leucine-rich repeat 64..84 CDD:275378 5/19 (26%)
LRR 2 84..105 6/20 (30%)
leucine-rich repeat 85..132 CDD:275378 16/46 (35%)
LRR 3 108..129 6/20 (30%)
LRR_8 131..>176 CDD:290566 14/44 (32%)
LRR_4 131..172 CDD:289563 12/40 (30%)
LRR 4 132..153 6/20 (30%)
leucine-rich repeat 133..156 CDD:275378 7/22 (32%)
LRR 5 156..177 7/20 (35%)
leucine-rich repeat 157..180 CDD:275378 7/22 (32%)
leucine-rich repeat 181..205 CDD:275378 2/23 (9%)
TPKR_C2 201..>241 CDD:301599 10/39 (26%)
Ig 258..346 CDD:299845 14/60 (23%)
IG_like 268..346 CDD:214653 12/50 (24%)
FN3 432..502 CDD:214495
LRR 6 526..549
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167831240
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.930

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