DRSC/TRiP Functional Genomics Resources

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Protein Alignment Con and Lrfn5

DIOPT Version :10

Sequence 1:NP_523930.3 Gene:Con / 38590 FlyBaseID:FBgn0005775 Length:691 Species:Drosophila melanogaster
Sequence 2:NP_848829.2 Gene:Lrfn5 / 238205 MGIID:2144814 Length:746 Species:Mus musculus


Alignment Length:313 Identity:86/313 - (27%)
Similarity:131/313 - (41%) Gaps:64/313 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   232 RLRELNLEHNQIFEMDRYAFRNLPLCERLFLNNNNISTLHEGLFADMARLTFLNLAHNQINVLTS 296
            |..||.|..|.:..:.|..|.|:.....|.|:.|.||.:....|||:..|..|:|..|::..:|:
Mouse    52 RTVELRLADNFVTNIKRKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITN 116

  Fly   297 EIFRGLGNLNVLKLTRNNLNFIGDTVFAELWSLSELELDDNRIERISERALDGLNTLKTLNLRNN 361
            ::|.||.||:.|.|..|.|..|..|.|.::::|.||:|..|.:|.|...|::.:.:|.||:|.:|
Mouse   117 DMFSGLSNLHHLILNNNQLTLISSTAFDDVFALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHN 181

  Fly   362 LLKKIDNGLLRGTPALLSINVQANKLETL----TFYTFQPIMDNLVNSTSELLVS--DNKFICDC 420
            ::..|..|.......:..::|.:|||:.|    .|...|.:..:.:.|.|...:|  .|...|:|
Mouse   182 MIDNIPKGTFSHLHKMTRLDVTSNKLQKLPPDPLFQRAQVLATSGIISPSTFALSFGGNPLHCNC 246

  Fly   421 RLQWIFELKNR--------------------------------TRHLQLRDSLEDLHCTLQ---- 449
            .|.|:..|...                                |||......||....||:    
Mouse   247 ELLWLRRLSREDDLETCASPALLTGRYFWSIPEEEFLCEPPLITRHTHEMRVLEGQRATLRCKAR 311

  Fly   450 ---EPKLSHFVDPVPPTI-------------LDVL-----NIGGFTAIGSNSA 481
               ||.: |::.|....|             ||:|     :.|.||.|.||.|
Mouse   312 GDPEPAI-HWISPEGKLISNATRSLVYDNGTLDILITTVKDTGAFTCIASNPA 363

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ConNP_523930.3 LRR <157..459 CDD:443914 74/271 (27%)
leucine-rich repeat 185..208 CDD:275380
leucine-rich repeat 209..232 CDD:275380 86/313 (27%)
leucine-rich repeat 233..256 CDD:275380 7/22 (32%)
leucine-rich repeat 257..280 CDD:275380 8/22 (36%)
leucine-rich repeat 281..304 CDD:275380 8/22 (36%)
leucine-rich repeat 305..328 CDD:275380 8/22 (36%)
leucine-rich repeat 329..352 CDD:275380 8/22 (36%)
leucine-rich repeat 353..376 CDD:275380 7/22 (32%)
Lrfn5NP_848829.2 LRR 1 52..73 7/20 (35%)
leucine-rich repeat 53..76 CDD:275380 7/22 (32%)
LRR <55..>211 CDD:443914 51/155 (33%)
LRR 2 76..97 6/20 (30%)
leucine-rich repeat 77..100 CDD:275380 8/22 (36%)
LRR 3 100..121 6/20 (30%)
leucine-rich repeat 101..124 CDD:275380 8/22 (36%)
LRR 4 124..145 9/20 (45%)
leucine-rich repeat 125..148 CDD:275380 8/22 (36%)
LRR 5 148..169 8/20 (40%)
leucine-rich repeat 149..172 CDD:275380 8/22 (36%)
LRR 6 172..193 7/20 (35%)
leucine-rich repeat 173..196 CDD:275380 7/22 (32%)
LRR 7 196..217 5/20 (25%)
leucine-rich repeat 197..215 CDD:275380 5/17 (29%)
LRRCT 240..>272 CDD:214507 6/31 (19%)
IgI_SALM5_like 287..374 CDD:409421 22/78 (28%)
Ig strand A 287..290 CDD:409421 0/2 (0%)
Ig strand A' 294..297 CDD:409421 0/2 (0%)
Ig strand B 303..311 CDD:409421 2/7 (29%)
Ig strand C 317..322 CDD:409421 1/5 (20%)
Ig strand C' 325..327 CDD:409421 0/1 (0%)
Ig strand D 333..337 CDD:409421 0/3 (0%)
Ig strand E 340..344 CDD:409421 1/3 (33%)
Ig strand F 354..361 CDD:409421 3/6 (50%)
Ig strand G 364..374 CDD:409421 86/313 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 385..416
FN3 421..494 CDD:473895
Blue background indicates that the domain is not in the aligned region.

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