DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Con and Lgi3

DIOPT Version :9

Sequence 1:	NP_001246635.1	Gene:	Con / 38590	FlyBaseID:	FBgn0005775	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_660254.1	Gene:	Lgi3 / 213469	MGIID:	2182619	Length:	548	Species:	Mus musculus

Alignment Length:	281	Identity:	60/281 - (21%)
Similarity:	105/281 - (37%)	Gaps:	83/281 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 SGSTGYSGP------MDSTGFC-----TRRRDMKL-----MCYCTPDENHVPVQKAECWVFSEGL 142
            :|.....||      :.:.|||     :.:|..|.     .|.||
Mouse     2 AGLRARRGPGRRLLVLSTLGFCLMLQVSAKRPPKTPPCPPSCSCT-------------------- 46

  Fly   143 HQNDTTWTRFYQQKRLRELKFVIQNNARLDYIPTMIIEPLKNLSSIVIEYSQVEI----VKSYAF 203
                            |:..|.:.:.:    :|       |||.|.||..:.|..    ::..||
Mouse    47 ----------------RDTAFCVDSKS----VP-------KNLPSEVISLTLVNAAFSEIQDGAF 84

  Fly   204 ANLPFLERIILNNNHIMALDQDAFANHIRLRELNLEHNQIFEMDRYAFRNLPLCERLFLNNNNIS 268
            ::||.|:.::||:|....:..:||.....|:.|.:|:|.|:.:.::.||.|.....|.|.|||:.
Mouse    85 SHLPLLQFLLLNSNKFTLIGDNAFIGLSHLQYLFIENNDIWALSKFTFRGLKSLTHLSLANNNLQ 149

  Fly   269 TLHEGLFADMARLTFLNLAHNQIN--VLTSEIFRGLGNLNVLKLTRNNLNFIGDTVFAELWSLSE 331
            ||...:|..:..|:.|:|..|.:|  .....:...|.:.|              |..|.::..|.
Mouse   150 TLPRDIFRPLDILSDLDLRGNALNCDCKVKWLVEWLAHTN--------------TTVAPIYCASP 200

  Fly   332 LELDDNRIERISERALDGLNT 352
            ....:::::.:..|..|.:.|
Mouse   201 PRFQEHKVQDLPLREFDCITT 221

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Con	NP_001246635.1	LRR_RI	<147..291	CDD:238064	40/147 (27%)
		LRR_8	183..243	CDD:290566	21/63 (33%)
		leucine-rich repeat	185..208	CDD:275380	8/26 (31%)
		leucine-rich repeat	209..232	CDD:275380	6/22 (27%)
		LRR_RI	<225..416	CDD:238064	31/130 (24%)
		LRR_8	232..291	CDD:290566	20/58 (34%)
		leucine-rich repeat	233..256	CDD:275380	8/22 (36%)
		leucine-rich repeat	257..280	CDD:275380	8/22 (36%)
		leucine-rich repeat	281..304	CDD:275380	6/24 (25%)
		LRR_8	304..363	CDD:290566	7/49 (14%)
		leucine-rich repeat	305..328	CDD:275380	3/22 (14%)
		leucine-rich repeat	329..352	CDD:275380	3/22 (14%)
		LRR_8	352..416	CDD:290566	1/1 (100%)
		leucine-rich repeat	353..376	CDD:275380	60/281 (21%)
		LRRCT	414..>450	CDD:214507
Lgi3	NP_660254.1	LRR_8	68..124	CDD:338972	15/55 (27%)
		leucine-rich repeat	68..89	CDD:275378	4/20 (20%)
		LRR 1	89..110		6/20 (30%)
		leucine-rich repeat	90..113	CDD:275378	6/22 (27%)
		LRR_8	113..172	CDD:338972	20/58 (34%)
		LRR 2	113..134		6/20 (30%)
		leucine-rich repeat	114..137	CDD:275378	8/22 (36%)
		LRR 3	137..158		8/20 (40%)
		leucine-rich repeat	138..161	CDD:275378	8/22 (36%)
		PCC	143..>218	CDD:188093	18/88 (20%)
		leucine-rich repeat	162..174	CDD:275378	4/11 (36%)
		EAR 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	222..264		60/281 (21%)
		EPTP	223..262	CDD:367630
		EAR 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	268..310
		EPTP	270..308	CDD:367630
		EAR 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	314..361
		EPTP	315..359	CDD:367630
		EAR 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	363..406
		EPTP	364..404	CDD:367630
		EAR 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	410..453
		EPTP	<422..451	CDD:367630
		EAR 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	455..497
		EPTP	456..495	CDD:367630
		EAR 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	501..543
		EPTP	502..541	CDD:367630
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831262
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X486
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.930