DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Con and LGI3

DIOPT Version :9

Sequence 1:	NP_001246635.1	Gene:	Con / 38590	FlyBaseID:	FBgn0005775	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_644807.1	Gene:	LGI3 / 203190	HGNCID:	18711	Length:	548	Species:	Homo sapiens

Alignment Length:	285	Identity:	63/285 - (22%)
Similarity:	107/285 - (37%)	Gaps:	101/285 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 GYSGP----MDSTGFC-----TRRRDMKL-----MCYCTPDENHVPVQKAECWVFSEGLHQNDTT 148
            |..||    :.:.|||     :.:|..|.     .|.||
Human     8 GGPGPGLLALSALGFCLMLQVSAKRPPKTPPCPPSCSCT-------------------------- 46

  Fly   149 WTRFYQQKRLRELKFVIQNNARLDYIPTMIIEPLKNLSSIVIEYSQVEI----VKSYAFANLPFL 209
                      |:..|.:.:.|    :|       :||.|.||..:.|..    ::..||::||.|
Human    47 ----------RDTAFCVDSKA----VP-------RNLPSEVISLTLVNAAFSEIQDGAFSHLPLL 90

  Fly   210 ERIILNNNHIMALDQDAFANHIRLRELNLEHNQIFEMDRYAFRNLPLCERLFLNNNNISTLHEGL 274
            :.::||:|....:..:||.....|:.|.:|:|.|:.:.::.||.|
Human    91 QFLLLNSNKFTLIGDNAFTGLSHLQYLFIENNDIWALSKFTFRGL-------------------- 135

  Fly   275 FADMARLTFLNLAHNQINVLTSEIFRGLGNLNVLKLTRNNLN----------FIG--DTVFAELW 327
                ..||.|:||:|.:..|..:|||.|..||.|.|..|:||          ::.  :|..|.::
Human   136 ----KSLTHLSLANNNLQTLPRDIFRPLDILNDLDLRGNSLNCDCKVKWLVEWLAHTNTTVAPIY 196

  Fly   328 SLSELELDDNRIERISERALDGLNT 352
            ..|.....:::::.:..|..|.:.|
Human   197 CASPPRFQEHKVQDLPLREFDCITT 221

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Con	NP_001246635.1	LRR_RI	<147..291	CDD:238064	34/147 (23%)
		LRR_8	183..243	CDD:290566	20/63 (32%)
		leucine-rich repeat	185..208	CDD:275380	8/26 (31%)
		leucine-rich repeat	209..232	CDD:275380	6/22 (27%)
		LRR_RI	<225..416	CDD:238064	34/140 (24%)
		LRR_8	232..291	CDD:290566	14/58 (24%)
		leucine-rich repeat	233..256	CDD:275380	8/22 (36%)
		leucine-rich repeat	257..280	CDD:275380	0/22 (0%)
		leucine-rich repeat	281..304	CDD:275380	11/22 (50%)
		LRR_8	304..363	CDD:290566	13/61 (21%)
		leucine-rich repeat	305..328	CDD:275380	9/34 (26%)
		leucine-rich repeat	329..352	CDD:275380	3/22 (14%)
		LRR_8	352..416	CDD:290566	1/1 (100%)
		leucine-rich repeat	353..376	CDD:275380	63/285 (22%)
		LRRCT	414..>450	CDD:214507
LGI3	NP_644807.1	LRR_8	68..124	CDD:290566	15/55 (27%)
		leucine-rich repeat	68..89	CDD:275378	4/20 (20%)
		LRR 1	89..110		6/20 (30%)
		leucine-rich repeat	90..113	CDD:275378	6/22 (27%)
		LRR_8	112..172	CDD:290566	24/83 (29%)
		LRR_4	113..152	CDD:289563	14/62 (23%)
		LRR 2	113..134		6/20 (30%)
		leucine-rich repeat	114..137	CDD:275378	8/46 (17%)
		LRR	135..158	CDD:197688	10/46 (22%)
		LRR 3	137..158		9/20 (45%)
		leucine-rich repeat	138..161	CDD:275378	11/22 (50%)
		leucine-rich repeat	162..174	CDD:275378	6/11 (55%)
		LRRCT	170..218	CDD:214507	7/47 (15%)
		EAR 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	222..264		63/285 (22%)
		EPTP	222..263	CDD:281697	63/285 (22%)
		EAR 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	268..310
		EPTP	268..309	CDD:281697
		EAR 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	314..361
		EPTP	314..359	CDD:281697
		EAR 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	363..406
		EPTP	363..405	CDD:281697
		EAR 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	410..453
		EPTP	410..452	CDD:281697
		EAR 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	455..497
		EPTP	455..496	CDD:281697
		EAR 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	501..543
		EPTP	501..541	CDD:281697
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141321
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X486
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.930