Protein Alignment Con and lron-1

DIOPT Version :10

• Sequence 1: NP_523930.3
• Gene: Con / 38590
• FlyBaseID: FBgn0005775
• Length: 691
• Species: Drosophila melanogaster
• Sequence 2: NP_510424.4
• Gene: lron-1 / 181553
• WormBaseID: WBGene00008093
• Length: 607
• Species: Caenorhabditis elegans
• Alignment Length: 573
• Identity: 130/573 - (22%)
• Similarity: 216/573 - (37%)
• Gaps: 140/573 - (24%)

  Fly    21 LLLSLLLIG-------------ACLVTPTEGRAKDDRRTRGRGSSSGVLSSSSSSSNNMNNGYYS 72
            ||.:||:.|             .|..|.|...|. .....|..|...||.|.|:|...:::  .:
 Worm     4 LLFNLLIAGWVYSQCPTLQLQEPCTCTSTRYEAV-SINCDGGSSLDAVLESLSNSPQAIDS--LT 65

  Fly    73 GSSSTAGSSSGYVFTSSSAV-----NSGSTGYSGPMDSTGFCTRRRDMKLMCYCTPDENHVPVQK 132
            .|::......||.|......     |:|...:. |...||..               ||  .:::
 Worm    66 ISNTPIEKMPGYAFQGFQIKKLFLRNNGLRSFH-PNTFTGNL---------------EN--SLEE 112

  Fly   133 AEC-WVFSEGLHQNDTTWTRFYQQKRLRELKFV---------IQNNARLDY-------------- 173
            .|. ..:.:|:.|:..:        .|::||.:         :|:||.|.|
 Worm   113 LEIRGNYIDGIPQSGVS--------ILKQLKILSLPDNLIEYVQDNAFLSYHSRDSLLKLDLSAN 169

  Fly   174 -----IPTMIIEPLKNLSSIVIEYSQVEIVKSYAFANLPFLERIILNNNHIMALDQDAFANHIRL 233
                 .||.:: .|:|||.:.::.:.:..:.|.|..|:|.||.:.|..|.|..:.:::.... .|
 Worm   170 NLTAIHPTGLL-GLENLSQLSLDKNLLSEIPSQALENIPSLEDLSLGVNRIHTISRNSLPLP-NL 232

  Fly   234 RELNLEHNQIFEMDRYAFRNLPLCERLFLNNNNISTLHEGLFADMARLTFLNLAHNQINVLTSEI 298
            :.|:||.|||..:...:|...||...|:|.||.::::...:|..:..|..|::::|:  .:||..
 Worm   233 KSLSLEVNQIRLIPSDSFSETPLLSYLYLGNNLLTSIDASMFLHIGGLKVLSMSNNK--DITSIQ 295

  Fly   299 FRGLGNLNVLKLTRNNLNF--IGDTVFAELW--SLSELE--------------LDDNRIERISER 345
            ..|..::...||....|.|  ....:..||:  |:|.:|              |..|:|.|||..
 Worm   296 ANGKLSVQQFKLCICILAFQHAPSLIRLELFDCSISRIEPKSLQKVQHIQVILLSRNQITRISHD 360

  Fly   346 ALDGLNTLKTLNLRNNLLKKIDNGLLRGTPALLSINVQANKLETLTFYTFQPIMDNLVNSTS--- 407
            ....|..|..|:|..|.:..:|:......|.|.|:::.:|:||:|   ....|.|:|:...:
 Worm   361 TFSNLPELSELDLSGNSINAVDDFAFSQLPMLTSLDLSSNRLESL---PSNVIYDSLMQKKTSPV 422

  Fly   408 --ELLVSDNKFICDCRLQWIFELKNRTRHLQLRD--------------------SLEDLHCTLQE 450
              :|.:.:|.:.||..|.|:        ...|||                    :|..|.....:
 Worm   423 QRKLSIQNNPWRCDKDLMWL--------RKWLRDNGDVTTAASNSPPAKCWTPSNLSGLDLRQTD 479

  Fly   451 PKLSHFVDPVPPTILDVLNIGGFTAIGSNSASMGGVGN---SVVGSSYSGLTM 500
            .||.|.....|   :|...........||..|..|..|   .|.|.:..||.:
 Worm   480 SKLPHKTTKPP---VDQFQYKNQQVTNSNGTSQLGYQNPHTEVNGLALVGLIL 529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Con	NP_523930.3	LRR	<157..459	CDD:443914	89/372 (24%)
		leucine-rich repeat	185..208	CDD:275380	5/22 (23%)
		leucine-rich repeat	209..232	CDD:275380	5/22 (23%)
		leucine-rich repeat	233..256	CDD:275380	8/22 (36%)
		leucine-rich repeat	257..280	CDD:275380	5/22 (23%)
		leucine-rich repeat	281..304	CDD:275380	6/22 (27%)
		leucine-rich repeat	305..328	CDD:275380	6/26 (23%)
		leucine-rich repeat	329..352	CDD:275380	9/36 (25%)
		leucine-rich repeat	353..376	CDD:275380	5/22 (23%)
lron-1	NP_510424.4	LRR	83..>400	CDD:443914	78/346 (23%)
		leucine-rich repeat	85..109	CDD:275380	7/41 (17%)
		leucine-rich repeat	110..133	CDD:275380	4/30 (13%)
		leucine-rich repeat	134..157	CDD:275380	7/22 (32%)
		leucine-rich repeat	161..184	CDD:275380	3/23 (13%)
		leucine-rich repeat	185..208	CDD:275380	5/22 (23%)
		leucine-rich repeat	209..231	CDD:275380	5/22 (23%)
		leucine-rich repeat	232..255	CDD:275380	8/22 (36%)
		leucine-rich repeat	256..279	CDD:275380	5/22 (23%)
		leucine-rich repeat	280..319	CDD:275380	10/40 (25%)
		leucine-rich repeat	320..343	CDD:275380	5/22 (23%)
		leucine-rich repeat	344..367	CDD:275380	7/22 (32%)
		leucine-rich repeat	368..391	CDD:275380	5/22 (23%)
		leucine-rich repeat	392..410	CDD:275380	6/20 (30%)
		leucine-rich repeat	414..435	CDD:275378	3/20 (15%)
		LRRCT	431..>472	CDD:214507	9/48 (19%)