DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Con and egg-6

DIOPT Version :9

Sequence 1:	NP_001246635.1	Gene:	Con / 38590	FlyBaseID:	FBgn0005775	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_492348.1	Gene:	egg-6 / 172670	WormBaseID:	WBGene00010621	Length:	961	Species:	Caenorhabditis elegans

Alignment Length:	544	Identity:	129/544 - (23%)
Similarity:	204/544 - (37%)	Gaps:	130/544 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   171 LDYIPTMIIEPLKNLSSIVIEYSQVEIVKSYAFANLPFLERIILNNNHIMALDQDAFANHIRLRE 235
            ||.||..|:....||..:.:..:.:..:.::...|||||..:.:.||.:..:...||.|..:|:.
Worm   187 LDAIPAQILRNAANLMYLDLGSNNISEINNFELMNLPFLRELRVQNNTLRRIHPMAFMNVPQLQY 251

  Fly   236 LNLEHNQIFEMD----------------------------------------------RYAFRNL 254
            |.|:.|.|..:|                                              ..||.|.
Worm   252 LYLQDNIISTLDGNRLQGFKNLEVLDVSNNALYALPSLKDLPNLKQVRVDGNLITKIETLAFSNN 316

  Fly   255 PLCERLFLNNNNISTLHEGLFADMARLTFLNLAHNQINVLTSEIFRGLGNLNVLKLTRNNLNFIG 319
            |..:.:.:.||||..:....|..:.:|..|.:.:|.:..:...:|.|:.||..|.:..|.|..:.
Worm   317 PNLQLISVQNNNIVQISRNSFESLDKLVVLLVGNNSLAKIERGMFDGMKNLQQLSIRNNTLTALD 381

  Fly   320 DTVFAELWSLSELELDDNRIERISERALDGLNTLKTLNLRNNLL---------KKIDNGLLRGTP 375
            .:.||:|..|:.|:|..|:|..|.|...|.|:.|..|:|.||.:         |||.|.||.|..
Worm   382 ASSFAQLAHLTTLDLGHNKIHDIEEGTFDKLSKLFWLDLSNNKISGFKTSVFKKKISNILLDGNQ 446

  Fly   376 ALL--SIN-----VQANKLETLTFYTFQP--------------IMDNLVNSTSELLVSDNKFICD 419
            .:.  |.|     :.|||:.  ||..||.              :.|.::...:|.|...:
Worm   447 LICDESFNEFLTYLIANKVR--TFLPFQQEIMCHGPEKYAGVRLKDLMMKKANETLSEGS----- 504

  Fly   420 CRLQWIFELKNRTRHLQLRDSLEDLH--CTLQE------PKLSHFVDPVPPTILDVLNIGGFTAI 476
             ||..:.:..|  :|..|...|..|.  .||..      |.::...:.: |.:..:...||...:
Worm   505 -RLLGVPQGSN--QHSLLSSFLPSLGPLGTLNGAGGAAIPLVNTLTNTI-PALRSIPGFGGNIPV 565

  Fly   477 GSNSASMGGVGNSVVGSSYSGLTMDDSRKHLGSRSRQALRGQRQFASSAENVVESKMRRRRKRQE 541
            |:.::|   |.|..:..:..|.|        |...|.|..|| ..||..|.::.| :........
Worm   566 GTGASS---VPNKNLNDAIEGFT--------GPLVRFATGGQ-PVASDIEQLIRS-IPNMVVNVP 617

  Fly   542 EVKEKDLAAVAPAHKRYDYYDDNNGGMSLGHGLD---LDDNL-----SLHKQGFYG-AGSPVVGH 597
            ...:.||:.:.|...:|..    |||..  .|:|   ||..:     .:|...... ||:||.|.
Worm   618 GFGDIDLSKMDPTMIQYVL----NGGQI--PGIDKATLDKIVKQTMNKMHTAAAANLAGNPVEGQ 676

  Fly   598 NDV----DVL---MTSHSASGDAL 614
            ..|    |.|   :.:...||:.|
Worm   677 EKVLPPLDKLPSGLVTQVMSGEPL 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Con	NP_001246635.1	LRR_RI	<147..291	CDD:238064	35/165 (21%)
		LRR_8	183..243	CDD:290566	16/59 (27%)
		leucine-rich repeat	185..208	CDD:275380	3/22 (14%)
		leucine-rich repeat	209..232	CDD:275380	6/22 (27%)
		LRR_RI	<225..416	CDD:238064	64/266 (24%)
		LRR_8	232..291	CDD:290566	18/104 (17%)
		leucine-rich repeat	233..256	CDD:275380	9/68 (13%)
		leucine-rich repeat	257..280	CDD:275380	5/22 (23%)
		leucine-rich repeat	281..304	CDD:275380	5/22 (23%)
		LRR_8	304..363	CDD:290566	22/58 (38%)
		leucine-rich repeat	305..328	CDD:275380	7/22 (32%)
		leucine-rich repeat	329..352	CDD:275380	9/22 (41%)
		LRR_8	352..416	CDD:290566	24/93 (26%)
		leucine-rich repeat	353..376	CDD:275380	12/31 (39%)
		LRRCT	414..>450	CDD:214507	9/37 (24%)
egg-6	NP_492348.1	LRR_8	107..162	CDD:290566
		leucine-rich repeat	107..127	CDD:275380
		leucine-rich repeat	128..151	CDD:275380
		LRR_RI	<144..281	CDD:238064	23/93 (25%)
		leucine-rich repeat	152..200	CDD:275380	5/12 (42%)
		LRR_8	176..233	CDD:290566	12/45 (27%)
		leucine-rich repeat	201..224	CDD:275380	3/22 (14%)
		LRR_8	225..283	CDD:290566	12/57 (21%)
		leucine-rich repeat	225..248	CDD:275380	6/22 (27%)
		LRR_RI	<240..458	CDD:238064	54/217 (25%)
		leucine-rich repeat	249..272	CDD:275380	6/22 (27%)
		LRR_8	271..329	CDD:290566	6/57 (11%)
		leucine-rich repeat	273..294	CDD:275380	0/20 (0%)
		leucine-rich repeat	295..318	CDD:275380	3/22 (14%)
		LRR_8	317..375	CDD:290566	14/57 (25%)
		leucine-rich repeat	319..342	CDD:275380	5/22 (23%)
		leucine-rich repeat	343..366	CDD:275380	5/22 (23%)
		LRR_8	365..425	CDD:290566	22/59 (37%)
		leucine-rich repeat	367..390	CDD:275380	7/22 (32%)
		leucine-rich repeat	391..414	CDD:275380	9/22 (41%)
		leucine-rich repeat	415..434	CDD:275380	5/18 (28%)
		leucine-rich repeat	437..449	CDD:275378	5/11 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45617
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100