DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Con and LINGO2

DIOPT Version :9

Sequence 1:	NP_001246635.1	Gene:	Con / 38590	FlyBaseID:	FBgn0005775	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_001245211.1	Gene:	LINGO2 / 158038	HGNCID:	21207	Length:	606	Species:	Homo sapiens

Alignment Length:	562	Identity:	118/562 - (20%)
Similarity:	185/562 - (32%)	Gaps:	240/562 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 MDSTGFCTRRRDMKLMCYCTPDENHVPVQKAECWVFSEGLHQNDTTWTRFYQQKRLRELKFVIQN 167
            |.||..|..|      |.|:.....|...:.......||:.
Human    22 MGSTIGCPAR------CECSAQNKSVSCHRRRLIAIPEGIP------------------------ 56

  Fly   168 NARLDYIPTMIIEPLKNLSSIVIEYSQVEIVKSYAFANLPFLERIILNNNHIMALDQDAFANHIR 232
                  |.|.|::..||         :::.|....|.:.|.||.|.|::|.|..::..||.|...
Human    57 ------IETKILDLSKN---------RLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFN 106

  Fly   233 LRELNLEHNQIFEMDRYAFRNLPLCERLFLNNNNISTLHEGLFADMARLTFLNLAHNQINVLTSE 297
            ||.|.|:.|::        :.:||                |:|..::.||.|:::.|:|.:|...
Human   107 LRSLRLKGNRL--------KLVPL----------------GVFTGLSNLTKLDISENKIVILLDY 147

  Fly   298 IFRGLGNLNVLKLTRNNLNFIGDTVFAELWSLSELELDDNRIERISERALDGLNTLKTLNLR--- 359
            :|:.|.||..|::..|:|.:|....|:.|.||.:|.|:...:..:...||..|.:|.:|:|:
Human   148 MFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLN 212

  Fly   360 -NNL----------LKKIDNG---LLRGTPA-------LLSINVQANKLETLTFYTFQPIM---- 399
             ||:          ||.::..   ||...||       |.|::|....|.|:.|..|:.::
Human   213 INNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLNLTSLSVTNTNLSTVPFLAFKHLVYLTH 277

  Fly   400 ----------------------------------------------------DNLVNSTSE---- 408
                                                                .||:.:..|
Human   278 LNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFS 342

  Fly   409 -------LLVSDNKFICDCRLQWIFELKNRTRHLQ-------------LRD-SLEDLHCT----- 447
                   |.:::|...|||||.||.:   |...||             :|: |.:|.|.|
Human   343 SPRALEVLSINNNPLACDCRLLWILQ---RQPTLQFGGQQPMCAGPDTIRERSFKDFHSTALSFY 404

  Fly   448 -------LQEPKLSHFV---------------DPVP-------------------PTIL--DVLN 469
                   ::|.||.|.:               ||.|                   .|:|  ..|.
Human   405 FTCKKPKIREKKLQHLLVDEGQTVQLECSADGDPQPVISWVTPRRRFITTKSNGRATVLGDGTLE 469

  Fly   470 I--------GGFTAIGSNSASMGGVGNSVVGSSYS--GLTMD 501
            |        |.:..|.||:|     ||....:|.:  |...|
Human   470 IRFAQDQDSGMYVCIASNAA-----GNDTFTASLTVKGFASD 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Con	NP_001246635.1	LRR_RI	<147..291	CDD:238064	30/143 (21%)
		LRR_8	183..243	CDD:290566	19/59 (32%)
		leucine-rich repeat	185..208	CDD:275380	2/22 (9%)
		leucine-rich repeat	209..232	CDD:275380	9/22 (41%)
		LRR_RI	<225..416	CDD:238064	58/281 (21%)
		LRR_8	232..291	CDD:290566	13/58 (22%)
		leucine-rich repeat	233..256	CDD:275380	5/22 (23%)
		leucine-rich repeat	257..280	CDD:275380	2/22 (9%)
		leucine-rich repeat	281..304	CDD:275380	8/22 (36%)
		LRR_8	304..363	CDD:290566	20/72 (28%)
		leucine-rich repeat	305..328	CDD:275380	7/22 (32%)
		leucine-rich repeat	329..352	CDD:275380	6/22 (27%)
		LRR_8	352..416	CDD:290566	23/154 (15%)
		leucine-rich repeat	353..376	CDD:275380	9/39 (23%)
		LRRCT	414..>450	CDD:214507	16/61 (26%)
LINGO2	NP_001245211.1	LRRNT	27..60	CDD:214470	8/68 (12%)
		leucine-rich repeat	39..57	CDD:275380	3/47 (6%)
		LRR 1	58..79		6/29 (21%)
		leucine-rich repeat	59..82	CDD:275380	6/31 (19%)
		LRR_8	60..117	CDD:316378	20/65 (31%)
		LRR 2	82..103		8/20 (40%)
		leucine-rich repeat	83..106	CDD:275380	9/22 (41%)
		LRR_8	106..165	CDD:316378	21/82 (26%)
		LRR 3	106..127		9/44 (20%)
		leucine-rich repeat	107..130	CDD:275380	9/46 (20%)
		LRR 4	130..151		7/20 (35%)
		leucine-rich repeat	131..154	CDD:275380	8/22 (36%)
		LRR_5	146..276	CDD:331043	35/129 (27%)
		LRR 5	154..175		7/20 (35%)
		leucine-rich repeat	155..178	CDD:275380	7/22 (32%)
		LRR 6	178..199		6/20 (30%)
		leucine-rich repeat	179..202	CDD:275380	6/22 (27%)
		LRR 7	202..223		5/20 (25%)
		leucine-rich repeat	203..250	CDD:275380	11/46 (24%)
		LRR 8	226..247		6/20 (30%)
		LRR_8	250..309	CDD:316378	7/58 (12%)
		LRR 9	250..271		7/20 (35%)
		leucine-rich repeat	251..274	CDD:275380	7/22 (32%)
		LRR 10	274..295		0/20 (0%)
		leucine-rich repeat	275..298	CDD:275380	0/22 (0%)
		LRR_8	298..357	CDD:316378	5/58 (9%)
		LRR 11	298..319		0/20 (0%)
		leucine-rich repeat	299..322	CDD:275380	0/22 (0%)
		LRR 12	322..343		3/20 (15%)
		leucine-rich repeat	323..343	CDD:275380	3/19 (16%)
		PCC	327..>391	CDD:188093	16/66 (24%)
		I-set	410..500	CDD:254352	19/94 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910