Protein Alignment Con and CHADL

DIOPT Version :10

• Sequence 1: NP_523930.3
• Gene: Con / 38590
• FlyBaseID: FBgn0005775
• Length: 691
• Species: Drosophila melanogaster
• Sequence 2: XP_054181131.1
• Gene: CHADL / 150356
• HGNCID: 25165
• Length: 771
• Species: Homo sapiens
• Alignment Length: 576
• Identity: 138/576 - (23%)
• Similarity: 201/576 - (34%)
• Gaps: 154/576 - (26%)

  Fly   119 CYCTPDENHVPVQKAECWVFSEGLHQNDTTWTRFYQQKRLREL--KFVIQNNARLDYIPTMIIEP 181
            |.|.....||..:           :||.|.     ....:.||  :..:|.|. |..||....:.
Human    37 CICDNSRRHVACR-----------YQNLTE-----VPDAIPELTQRLDLQGNL-LKVIPAAAFQG 84

  Fly   182 LKNLSSIVIEYSQVEIVKSYAFANLPFLERIILNNNHIMALDQDAFANHIRLRELNLEHNQIFEM 246
            :.:|:.:.:.:.:||:|...||..|..|..:.|.:||:..|.|:|......||.|.||.|.:.|:
Human    85 VPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQEALDGLGSLRRLELEGNALEEL 149

  Fly   247 DRYAFRNLPLCERLFLNNNNISTLHEGLFADMARLTFLNLAHNQINVLTSEIFRGLGNLNVLKLT 311
            ....|..|.....|.|.:|.:..|....|..:.|:.:|.|:||.::||..|...||..|..|.|.
Human   150 RPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSVLAPEALAGLPALRRLSLH 214

  Fly   312 RNNLNFIGDTVFAELWSLSELELDDNRIERISER---ALDGLNTLKTLNLRNNLLKKIDNGLLRG 373
            .|.|..:...|.::...|:.|||..|.:....|.   ||.||..|           .:|.|.|:.
Human   215 HNELQALPGPVLSQARGLARLELGHNPLTYAGEEDGLALPGLREL-----------LLDGGALQA 268

  Fly   374 --------TPALLSINVQANKLETLTFYTFQPIMDNLVNSTSELLVSDNKFICDCR----LQWIF 426
                    .|.|.:::::.|:|:||     .|:..  ......|.:..|...|.|:    |:|:.
Human   269 LGPRAFAHCPRLHTLDLRGNQLDTL-----PPLQG--PGQLRRLRLQGNPLWCGCQARPLLEWLA 326

  Fly   427 ELKNRT-------RHL--QLRDSLE--DLHC---------TLQE----------------PKLSH 455
            ..:.|:       |.|  :..|:|.  ||.|         .|:|                |....
Human   327 RARVRSDGACQGPRRLRGEALDALRPWDLRCPGDAAQEEEELEERAVAGPRAPPRGPPRGPGEER 391

  Fly   456 FVDPVPPTILDVLNIGGFTAIGSNSASMGGVGNSVVGSSYSGLT--MDDSRKHLGSRSRQALRGQ 518
            .|.|.|...:.|..        |..:|..|.|...|...:...|  :|..|.|..|..|.|..|.
Human   392 AVAPCPRACVCVPE--------SRHSSCEGCGLQAVPRGFPSDTQLLDLRRNHFPSVPRAAFPGL 448

  Fly   519 RQFASSAENVVESKMRRRRKRQEEVKEKDLAAVAPAHKR-YDYYDDN----------NGGMSLGH 572
            ....|            ...:...:.|.:..|:|...:. |.|..||          .|...||:
Human   449 GHLVS------------LHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALEGAPRLGY 501

  Fly   573 GLDLDDN----------------LSLHKQGFYGAGSPVVGHNDVDVLMTSHSASGD 612
             |.|:.|                .|||.|           .|.||.|     |.||
Human   502 -LYLERNRFLQVPGAALRALPSLFSLHLQ-----------DNAVDRL-----APGD 540

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Con	NP_523930.3	LRR	<157..459	CDD:443914	90/354 (25%)
		leucine-rich repeat	185..208	CDD:275380	7/22 (32%)
		leucine-rich repeat	209..232	CDD:275380	7/22 (32%)
		leucine-rich repeat	233..256	CDD:275380	9/22 (41%)
		leucine-rich repeat	257..280	CDD:275380	5/22 (23%)
		leucine-rich repeat	281..304	CDD:275380	9/22 (41%)
		leucine-rich repeat	305..328	CDD:275380	6/22 (27%)
		leucine-rich repeat	329..352	CDD:275380	10/25 (40%)
		leucine-rich repeat	353..376	CDD:275380	4/30 (13%)
CHADL	XP_054181131.1	LRRNT	33..65	CDD:214470	9/43 (21%)
		leucine-rich repeat	44..62	CDD:275380	5/33 (15%)
		leucine-rich repeat	64..87	CDD:275380	5/23 (22%)
		LRR_8	65..146	CDD:404697	25/81 (31%)
		leucine-rich repeat	88..135	CDD:275380	14/46 (30%)
		LRR	<128..>312	CDD:443914	54/201 (27%)
		leucine-rich repeat	136..159	CDD:275380	9/22 (41%)
		leucine-rich repeat	160..183	CDD:275380	5/22 (23%)
		leucine-rich repeat	184..207	CDD:275380	9/22 (41%)
		leucine-rich repeat	208..231	CDD:275380	6/22 (27%)
		leucine-rich repeat	232..255	CDD:275380	8/22 (36%)
		leucine-rich repeat	256..279	CDD:275380	5/33 (15%)
		LRRNT	395..429	CDD:214470	9/41 (22%)
		leucine-rich repeat	410..426	CDD:275380	4/15 (27%)
		leucine-rich repeat	427..450	CDD:275380	8/22 (36%)
		LRR	<445..>677	CDD:443914	26/125 (21%)
		leucine-rich repeat	451..474	CDD:275380	4/34 (12%)
		leucine-rich repeat	475..498	CDD:275380	5/22 (23%)
		leucine-rich repeat	499..522	CDD:275380	5/23 (22%)
		leucine-rich repeat	523..546	CDD:275380	11/34 (32%)
		leucine-rich repeat	547..570	CDD:275380
		leucine-rich repeat	571..594	CDD:275380
		leucine-rich repeat	595..619	CDD:275380
		leucine-rich repeat	620..644	CDD:275380
		LRRCT	675..723	CDD:214507