DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Con and Chad

DIOPT Version :9

Sequence 1:	NP_001246635.1	Gene:	Con / 38590	FlyBaseID:	FBgn0005775	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_031715.1	Gene:	Chad / 12643	MGIID:	1096866	Length:	358	Species:	Mus musculus

Alignment Length:	338	Identity:	89/338 - (26%)
Similarity:	144/338 - (42%)	Gaps:	46/338 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 CYCTPDENHVPVQKAECWVFSEGLHQ----NDTTWTRFYQQKRLRELKFVIQNNARLDYIPTMI- 178
            |:|..|..||...|.       ||.:    ::||        :|..|:   :||     .|.:.
Mouse    26 CHCHGDLQHVICDKV-------GLQKIPKVSETT--------KLLNLQ---RNN-----FPVLAA 67

  Fly   179 --IEPLKNLSSIVIEYSQVEIVKSYAFANLPFLERIILNNNHIMALDQDAFANHIRLRELNLEHN 241
              ...:.||.|:.:::..:..|.:.||..|..|..:.|::|.|..|...||.:...|..|.|:||
Mouse    68 NSFRTMPNLVSLHLQHCNIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGAFDDLTELTYLYLDHN 132

  Fly   242 QIFEMDRYAFRNLPLCERLFLNNNNISTLHEGLFADMARLTFLNLAHNQINVLTSEIFRGLGNLN 306
            ::.|:.|.....|.....|.||||.|..|..|.|.....|.:|.|:.|.::.|.......:.||.
Mouse   133 KVSELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSENALSSLQPGSLDDVENLA 197

  Fly   307 VLKLTRNNLNFIGDTVFAELWSLSELELDDNRIERISERALDGLNT-LKTLNLRNNLLKKIDNGL 370
            ...|.:|.|:.......::|..:.||:|..|.::.|.:.|...... |:||.|.|..|:|..:..
Mouse   198 KFHLDKNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAFQSFGRYLETLWLDNTNLEKFSDAA 262

  Fly   371 LRGTPALLSINVQANKLETL-TFYTFQPIMDNLVNSTSELLVSDNKFICDCRLQWIFELKNRTRH 434
            ..|...|..:::..|:|..| :.:.|    |||    ..|.:::|.:.|.|      :|:...|.
Mouse   263 FSGVTTLKHVHLDNNRLNQLPSSFPF----DNL----ETLTLTNNPWKCTC------QLRGLRRW 313

  Fly   435 LQLRDSLEDLHCT 447
            |:.:.|..|..|:
Mouse   314 LEAKASRPDATCS 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Con	NP_001246635.1	LRR_RI	<147..291	CDD:238064	42/146 (29%)
		LRR_8	183..243	CDD:290566	19/59 (32%)
		leucine-rich repeat	185..208	CDD:275380	6/22 (27%)
		leucine-rich repeat	209..232	CDD:275380	7/22 (32%)
		LRR_RI	<225..416	CDD:238064	54/192 (28%)
		LRR_8	232..291	CDD:290566	21/58 (36%)
		leucine-rich repeat	233..256	CDD:275380	8/22 (36%)
		leucine-rich repeat	257..280	CDD:275380	9/22 (41%)
		leucine-rich repeat	281..304	CDD:275380	5/22 (23%)
		LRR_8	304..363	CDD:290566	17/59 (29%)
		leucine-rich repeat	305..328	CDD:275380	5/22 (23%)
		leucine-rich repeat	329..352	CDD:275380	6/22 (27%)
		LRR_8	352..416	CDD:290566	18/65 (28%)
		leucine-rich repeat	353..376	CDD:275380	8/22 (36%)
		LRRCT	414..>450	CDD:214507	9/34 (26%)
Chad	NP_031715.1	LRRNT	22..48	CDD:279764	8/28 (29%)
		LRR 1	51..72		7/36 (19%)
		leucine-rich repeat	52..75	CDD:275380	6/38 (16%)
		LRR_8	74..134	CDD:290566	19/59 (32%)
		LRR 2	75..96		6/20 (30%)
		leucine-rich repeat	76..99	CDD:275380	6/22 (27%)
		LRR_RI	<89..281	CDD:238064	56/191 (29%)
		LRR 3	99..120		7/20 (35%)
		leucine-rich repeat	100..123	CDD:275380	7/22 (32%)
		LRR 4	123..144		7/20 (35%)
		leucine-rich repeat	124..147	CDD:275380	8/22 (36%)
		LRR_8	147..206	CDD:290566	18/58 (31%)
		LRR 5	147..168		9/20 (45%)
		leucine-rich repeat	148..171	CDD:275380	9/22 (41%)
		LRR 6	171..192		5/20 (25%)
		leucine-rich repeat	172..195	CDD:275380	5/22 (23%)
		LRR 7	195..216		5/20 (25%)
		leucine-rich repeat	196..219	CDD:275380	5/22 (23%)
		LRR 8	219..240		6/20 (30%)
		LRR_8	220..279	CDD:290566	16/58 (28%)
		leucine-rich repeat	220..243	CDD:275380	6/22 (27%)
		LRR 9	244..265		7/20 (35%)
		leucine-rich repeat	245..268	CDD:275380	8/22 (36%)
		LRR 10	268..289		5/24 (21%)
		leucine-rich repeat	269..291	CDD:275380	6/25 (24%)
		LRRCT	299..346	CDD:214507	9/34 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	322..358		2/5 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831264
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930