Protein Alignment Con and LRG1

DIOPT Version :10

• Sequence 1: NP_523930.3
• Gene: Con / 38590
• FlyBaseID: FBgn0005775
• Length: 691
• Species: Drosophila melanogaster
• Sequence 2: NP_443204.1
• Gene: LRG1 / 116844
• HGNCID: 29480
• Length: 347
• Species: Homo sapiens
• Alignment Length: 265
• Identity: 66/265 - (24%)
• Similarity: 105/265 - (39%)
• Gaps: 28/265 - (10%)

  Fly   171 LDYIPTMIIEPLKNLSSIVIEYSQVEIVKSYAFANLPFLERIILNNNHIMALDQDAFANHIRLRE 235
            |.::|..:::....|..:.:..:.:|.:.......:|.|..:.|..|.:..|....|.....|..
Human    80 LTHLPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPPGLFQASATLDT 144

  Fly   236 LNLEHNQIFEMDRYAFRNLPLCERLFLNNNNISTLHEGLFADMARLTFLNLAHNQINVLTSEIFR 300
            |.|:.||:..::......|.....|.|:.|.:..|..||.|:...|..|:|..||:..|..::.|
Human   145 LVLKENQLEVLEVSWLHGLKALGHLDLSGNRLRKLPPGLLANFTLLRTLDLGENQLETLPPDLLR 209

  Fly   301 GLGNLNVLKLTRNNLNFIGDTVFAELWSLSELELDDNRIERISERALDGLNTLKTLNLRNNLLKK 365
            |...|..|.|..|.|..:|..:......|..|.|:.|::.|::..|..||..|..|:|.||.|..
Human   210 GPLQLERLHLEGNKLQVLGKDLLLPQPDLRYLFLNGNKLARVAAGAFQGLRQLDMLDLSNNSLAS 274

  Fly   366 IDNGLLRGTPALLSINVQANKLETLTFYTFQPIMDNLVNSTSELLVSDNKFICDCRL----QWIF 426
            :..||.    |.|.                ||..|    ......:|.|.:|||..|    :|:.
Human   275 VPEGLW----ASLG----------------QPNWD----MRDGFDISGNPWICDQNLSDLYRWLQ 315

  Fly   427 ELKNR 431
            ..|::
Human   316 AQKDK 320

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Con	NP_523930.3	LRR	<157..459	CDD:443914	66/265 (25%)
		leucine-rich repeat	185..208	CDD:275380	2/22 (9%)
		leucine-rich repeat	209..232	CDD:275380	5/22 (23%)
		leucine-rich repeat	233..256	CDD:275380	6/22 (27%)
		leucine-rich repeat	257..280	CDD:275380	7/22 (32%)
		leucine-rich repeat	281..304	CDD:275380	8/22 (36%)
		leucine-rich repeat	305..328	CDD:275380	6/22 (27%)
		leucine-rich repeat	329..352	CDD:275380	8/22 (36%)
		leucine-rich repeat	353..376	CDD:275380	8/22 (36%)
LRG1	NP_443204.1	LRR	<79..319	CDD:443914	65/262 (25%)
		LRR 1	93..114		2/20 (10%)
		leucine-rich repeat	94..117	CDD:275380	2/22 (9%)
		LRR 2	117..138		5/20 (25%)
		leucine-rich repeat	118..141	CDD:275380	5/22 (23%)
		LRR 3	141..162		5/20 (25%)
		leucine-rich repeat	142..165	CDD:275380	6/22 (27%)
		LRR 4	165..186		6/20 (30%)
		leucine-rich repeat	166..189	CDD:275380	7/22 (32%)
		LRR 5	189..210		6/20 (30%)
		leucine-rich repeat	190..213	CDD:275380	8/22 (36%)
		LRR 6	213..234		6/20 (30%)
		leucine-rich repeat	214..237	CDD:275380	6/22 (27%)
		LRR 7	237..258		6/20 (30%)
		leucine-rich repeat	238..261	CDD:275380	8/22 (36%)
		LRR 8	261..282		8/24 (33%)
		leucine-rich repeat	262..285	CDD:275380	10/42 (24%)
		LRRCT	299..346	CDD:214507	7/22 (32%)