DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Con and ELFN2

DIOPT Version :9

Sequence 1:	NP_001246635.1	Gene:	Con / 38590	FlyBaseID:	FBgn0005775	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_443138.2	Gene:	ELFN2 / 114794	HGNCID:	29396	Length:	820	Species:	Homo sapiens

Alignment Length:	641	Identity:	128/641 - (19%)
Similarity:	199/641 - (31%)	Gaps:	241/641 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 GFCTRRRDMKLMCYCTPDENHVPVQKAECWVFSEGLHQNDTTWTRFYQQKRLRELKFVIQNNARL 171
            |.|.    ..|:|.|.|.     ..:|:||:. ||  .....|           |....||....
Human     5 GLCA----AALLCVCRPG-----AVRADCWLI-EG--DKGYVW-----------LAICSQNQPPY 46

  Fly   172 DYIPTMIIEPLKNLSSIVIEYSQVEIVKSYAFANLPFLERIILNNNHIMALDQDAFANHIRLREL 236
            :.||..|...:.:|.                           ||.|.:.|:...:......|.:|
Human    47 ETIPQHINSTVHDLR---------------------------LNENKLKAVLYSSLNRFGNLTDL 84

  Fly   237 NLEHNQIFEMDRYAFRNLPLCERLFLNNNNISTLHEGLFADMARLTFLNLAHNQINVLTSEIFRG 301
            ||..|:|..::..||......:.|.|..|.:|.|.||:...|:||.||.:.||.|.|:|...|..
Human    85 NLTKNEISYIEDGAFLGQSSLQVLQLGYNKLSNLTEGMLRGMSRLQFLFVQHNLIEVVTPTAFSE 149

  Fly   302 LGNLNVLKLTRNNLNFIGDTVFAELWSLSELELDDN--------------------------RIE 340
            ..:|..:.|:.|.|:.:....||.|.||...||..|                          |::
Human   150 CPSLISIDLSSNRLSRLDGATFASLASLMVCELAGNPFNCECDLFGFLAWLVVFNNVTKNYDRLQ 214

  Fly   341 RISERALDGLNTL-----KTLNLRNNLLKKIDNGLLRGTPA------------------------ 376
            ..|.|...|...|     .:||....|..|..||.|...|.
Human   215 CESPREFAGYPLLVPRPYHSLNAITVLQAKCRNGSLPARPVSHPTPYSTDAQREPDENSGFNPDE 279

  Fly   377 LLSINVQAN-----------KLETLTF--YTFQPIMDNLVNSTSELLVSDNKFICDCRLQWIFEL 428
            :||:...|:           ||..:||  .|...|:.:..:....|:..:|.:..|     :..|
Human   280 ILSVEPPASSTTDASAGPAIKLHHVTFTSATLVVIIPHPYSKMYILVQYNNSYFSD-----VMTL 339

  Fly   429 KNRTRHL---QLRDSLEDLHCTL---QEPKLSHFV------DPVPPTILDVLNIGGFTAIGSNSA 481
            ||:...:   :||...|...|..   ...:.:|..      ||||
Human   340 KNKKEIVTLDKLRAHTEYTFCVTSLRNSRRFNHTCLTFTTRDPVP-------------------- 384

  Fly   482 SMGGVGNSVVGSSYSGLTMDDSRKHLGSRSRQALRGQRQFASSAENVVESKMRRRRKRQEEVKEK 546
              |.:..|...:::..:|:      ||......:         ....|...:|:||.::|:.|..
Human   385 --GDLAPSTSTTTHYIMTI------LGCLFGMVI---------VLGAVYYCLRKRRMQEEKQKSV 432

  Fly   547 DLAAVAPAHKRYDYYDDNNGGMSLGHGLDLDDNLSLHKQGFYGAGSPVVGHNDVDVLMTSHSASG 611
            ::....               :.:.:|.|:|            |||.|            |:|
Human   433 NVKKTI---------------LEMRYGADVD------------AGSIV------------HAA-- 456

  Fly   612 DALDILTTKNAIYIKLFLLKPEMLPCHDELSDPTELPLSRDLMDVRSNVGQDMSTA 667
                                       .:|.:|..||:|| :..:.|.:|:.:.||
Human   457 ---------------------------QKLGEPPVLPVSR-MASIPSMIGEKLPTA 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Con	NP_001246635.1	LRR_RI	<147..291	CDD:238064	34/143 (24%)
		LRR_8	183..243	CDD:290566	10/59 (17%)
		leucine-rich repeat	185..208	CDD:275380	1/22 (5%)
		leucine-rich repeat	209..232	CDD:275380	4/22 (18%)
		LRR_RI	<225..416	CDD:238064	62/258 (24%)
		LRR_8	232..291	CDD:290566	22/58 (38%)
		leucine-rich repeat	233..256	CDD:275380	8/22 (36%)
		leucine-rich repeat	257..280	CDD:275380	8/22 (36%)
		leucine-rich repeat	281..304	CDD:275380	9/22 (41%)
		LRR_8	304..363	CDD:290566	19/89 (21%)
		leucine-rich repeat	305..328	CDD:275380	7/22 (32%)
		leucine-rich repeat	329..352	CDD:275380	8/48 (17%)
		LRR_8	352..416	CDD:290566	20/105 (19%)
		leucine-rich repeat	353..376	CDD:275380	8/27 (30%)
		LRRCT	414..>450	CDD:214507	9/41 (22%)
ELFN2	NP_443138.2	LRR 1	56..77		5/47 (11%)
		leucine-rich repeat	60..80	CDD:275378	5/46 (11%)
		LRR_8	80..139	CDD:316378	22/58 (38%)
		LRR 2	80..101		8/20 (40%)
		leucine-rich repeat	81..104	CDD:275378	8/22 (36%)
		LRR 3	104..125		7/20 (35%)
		leucine-rich repeat	105..128	CDD:275378	8/22 (36%)
		LRR_8	127..187	CDD:316378	22/59 (37%)
		LRR 4	128..149		10/20 (50%)
		leucine-rich repeat	129..152	CDD:275378	9/22 (41%)
		LRR 5	152..173		5/20 (25%)
		leucine-rich repeat	153..166	CDD:275378	4/12 (33%)
		PCC	157..>227	CDD:188093	15/69 (22%)
		leucine-rich repeat	200..226	CDD:275380	4/25 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..294		5/43 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	508..527
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	589..612
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	654..677
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141319
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840