DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Con and Lrrtm2

DIOPT Version :9

Sequence 1:	NP_001246635.1	Gene:	Con / 38590	FlyBaseID:	FBgn0005775	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_821072.1	Gene:	Lrrtm2 / 107065	MGIID:	2389174	Length:	515	Species:	Mus musculus

Alignment Length:	331	Identity:	93/331 - (28%)
Similarity:	141/331 - (42%)	Gaps:	66/331 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   214 LNNNHIMALDQDAFANHIRLRELNLEHNQIFEMDRYAFRNLPLCERLFLNNNNISTLHEGLFADM 278
            |.:|||.||::|.||:..:|..|:|:||||..:...||:.|...:.|.|::|.|..|....|..:
Mouse    68 LRHNHITALERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLPNTTFTQL 132

  Fly   279 ARLTFLNLAHNQINVLTSEIFRGLGNLNVLKLTRNNLNFIGDTVFAELWSLSELELDDNRIERIS 343
            ..|..|:|:.||::.|..|:|.||..|..|.|..|:|..|...:|.:..||..|:|..||:..::
Mouse   133 INLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRLRSLA 197

  Fly   344 ERALDGLNTLKTLNLRNNLLKKIDNGLLRGTPALLSINVQANKLETLT----------------- 391
            .....||..|:.|:|.:|.|.||:........:|.::.:|.||:..||
Mouse   198 RNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNLTCGMDWTWSTLEKLDLTG 262

  Fly   392 ----------FYTFQP----IMDN---------LVNSTSELL---VSDNKFICDCRL----QWIF 426
                      |.|...    :|||         ::||...|.   :|.|.:.|..|:    .|:.
Mouse   263 NEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLKSLTTVGLSGNLWECSPRVCALASWLG 327

  Fly   427 ELKNRTR---------HLQLRDSLEDLH----CTLQEPKLSHFVDPVPPTILDVLNIGGFTAIGS 478
            ..:.|..         |.|..|.|:.:|    |.    .||..|..:..|..|...  .:|.|.|
Mouse   328 SFQGRWEHSILCHSPDHTQGEDILDAVHGFQLCW----NLSTTVTAMATTYRDPTT--EYTKISS 386

  Fly   479 NSASMG 484
            :|..:|
Mouse   387 SSYHVG 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Con	NP_001246635.1	LRR_RI	<147..291	CDD:238064	29/76 (38%)
		LRR_8	183..243	CDD:290566	14/28 (50%)
		leucine-rich repeat	185..208	CDD:275380
		leucine-rich repeat	209..232	CDD:275380	9/17 (53%)
		LRR_RI	<225..416	CDD:238064	67/233 (29%)
		LRR_8	232..291	CDD:290566	20/58 (34%)
		leucine-rich repeat	233..256	CDD:275380	10/22 (45%)
		leucine-rich repeat	257..280	CDD:275380	6/22 (27%)
		leucine-rich repeat	281..304	CDD:275380	10/22 (45%)
		LRR_8	304..363	CDD:290566	19/58 (33%)
		leucine-rich repeat	305..328	CDD:275380	7/22 (32%)
		leucine-rich repeat	329..352	CDD:275380	7/22 (32%)
		LRR_8	352..416	CDD:290566	23/106 (22%)
		leucine-rich repeat	353..376	CDD:275380	7/22 (32%)
		LRRCT	414..>450	CDD:214507	11/52 (21%)
Lrrtm2	NP_821072.1	LRR 1	63..83		8/14 (57%)
		LRR	<65..312	CDD:227223	72/243 (30%)
		leucine-rich repeat	66..86	CDD:275380	9/17 (53%)
		LRR 2	86..107		9/20 (45%)
		leucine-rich repeat	87..110	CDD:275380	10/22 (45%)
		LRR 3	110..131		6/20 (30%)
		leucine-rich repeat	111..134	CDD:275380	6/22 (27%)
		LRR 4	134..155		8/20 (40%)
		leucine-rich repeat	135..158	CDD:275380	10/22 (45%)
		LRR 5	158..179		7/20 (35%)
		leucine-rich repeat	159..182	CDD:275380	7/22 (32%)
		LRR 6	182..203		6/20 (30%)
		leucine-rich repeat	183..206	CDD:275380	7/22 (32%)
		LRR 7	206..227		7/20 (35%)
		leucine-rich repeat	207..230	CDD:275380	7/22 (32%)
		LRR 8	230..251		6/20 (30%)
		leucine-rich repeat	231..254	CDD:275380	6/22 (27%)
		LRR 9	254..275		1/20 (5%)
		leucine-rich repeat	255..278	CDD:275380	2/22 (9%)
		LRR 10	278..299		3/20 (15%)
		leucine-rich repeat	279..300	CDD:275380	4/20 (20%)
		PCC	284..>351	CDD:188093	15/66 (23%)
		Involved in DLG4-binding. /evidence=ECO:0000250	512..515
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831220
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.930