DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Con and lrig1

DIOPT Version :9

Sequence 1:	NP_001246635.1	Gene:	Con / 38590	FlyBaseID:	FBgn0005775	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	XP_002938412.1	Gene:	lrig1 / 100491453	XenbaseID:	XB-GENE-494193	Length:	1043	Species:	Xenopus tropicalis

Alignment Length:	425	Identity:	112/425 - (26%)
Similarity:	178/425 - (41%)	Gaps:	62/425 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   170 RLDYIPTMIIEPLKNLSSIVIEYSQVEIVKSYAFANLPFLERIILNNNHIMALDQDAFANHIRLR 234
            |:..:|..:.. |..|:.:.:..:::.:::...|..|..||.:.|..|:|..|...||....|::
Frog   186 RISQLPVKVFR-LPRLTQLELNRNRIRLIEGLTFQGLESLEVLKLQRNNISKLTDGAFWGLSRMQ 249

  Fly   235 ELNLEHNQIFEMDRYAFRNLPLCERLFLNNNNISTLHEGLFADMARLTFLNLAHNQINVLTSEIF 299
            .|:||:|.:.|::..:...|...::|.|::|:|||:....::...:|..|.|:||.:..|.....
Frog   250 ILHLENNSLTEVNSGSLYGLLSLQQLHLSHNSISTISSAGWSFCQKLQELVLSHNNLTRLDEGSL 314

  Fly   300 RGLGNLNVLKLTRNNLNFIGDTVFAELWSLSELELDDNRIERISE---RALDGLNTLKTLNLRNN 361
            ..||.|:||:|:.|:::.|.:..|..|.||..||||.|.|....|   .|..||.:|..|.|..|
Frog   315 ADLGVLDVLRLSYNSISHIAEGAFKGLKSLRILELDHNEISGTIEDTNGAFIGLESLNKLTLFGN 379

  Fly   362 LLKKIDNGLLRGTPALLSINVQANKLETLTFYTFQPIMDNLVNSTSELLVSDNKFICDCRLQWIF 426
            .:|.:......|..:|..:|:..|.|.::....|.. |.||    .||:|..:.|:|||.|:|:.
Frog   380 KIKSVAKRAFSGIESLEHLNLGENALRSVHSEAFGE-MKNL----KELVVGSSSFLCDCHLKWLP 439

  Fly   427 ELKNRTRHLQLRDSLEDLH-------CTLQEPKLSHFVDPVPPTILDVLNIGGFTAIGSNSASMG 484
            :... :|.||.:......|       .....|..|...|.:|...:.|          ....:|.
Frog   440 QWLT-SRRLQTKVKASCAHPGSLNNTSIFSVPPRSFVCDDLPKPQIRV----------QPETTMA 493

  Fly   485 GVGN------SVVGSSYSGLTM----DDSRKHLGSRSRQALRGQRQFASSAENVVESKMRRRRKR 539
            .:|.      |...||.|.:|.    |:...|...        ...|||..|            |
Frog   494 VLGKAIRFTCSAASSSPSPMTFAWKKDNEILHNAE--------VENFASGTE------------R 538

  Fly   540 QEEVKE----KDLAAVAPAHK-RYDYYDDNNGGMS 569
            :.||.|    ..|..:..||: ||.....|:.|.|
Frog   539 EGEVTEYTTILHLRNLTFAHEGRYQCIITNDFGPS 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Con	NP_001246635.1	LRR_RI	<147..291	CDD:238064	32/120 (27%)
		LRR_8	183..243	CDD:290566	16/59 (27%)
		leucine-rich repeat	185..208	CDD:275380	3/22 (14%)
		leucine-rich repeat	209..232	CDD:275380	8/22 (36%)
		LRR_RI	<225..416	CDD:238064	60/193 (31%)
		LRR_8	232..291	CDD:290566	18/58 (31%)
		leucine-rich repeat	233..256	CDD:275380	6/22 (27%)
		leucine-rich repeat	257..280	CDD:275380	6/22 (27%)
		leucine-rich repeat	281..304	CDD:275380	7/22 (32%)
		LRR_8	304..363	CDD:290566	24/61 (39%)
		leucine-rich repeat	305..328	CDD:275380	8/22 (36%)
		leucine-rich repeat	329..352	CDD:275380	11/25 (44%)
		LRR_8	352..416	CDD:290566	17/63 (27%)
		leucine-rich repeat	353..376	CDD:275380	6/22 (27%)
		LRRCT	414..>450	CDD:214507	10/42 (24%)
lrig1	XP_002938412.1	LRRNT	28..59	CDD:214470
		leucine-rich repeat	57..80	CDD:275378
		PLN00113	<58..>370	CDD:215061	55/184 (30%)
		leucine-rich repeat	104..127	CDD:275380
		leucine-rich repeat	128..151	CDD:275380
		leucine-rich repeat	152..199	CDD:275380	3/13 (23%)
		leucine-rich repeat	200..223	CDD:275380	3/22 (14%)
		leucine-rich repeat	224..247	CDD:275380	8/22 (36%)
		leucine-rich repeat	248..295	CDD:275380	12/46 (26%)
		leucine-rich repeat	272..292	CDD:275380	6/19 (32%)
		leucine-rich repeat	296..319	CDD:275380	7/22 (32%)
		leucine-rich repeat	320..343	CDD:275380	8/22 (36%)
		LRR_8	343..405	CDD:338972	21/61 (34%)
		leucine-rich repeat	344..370	CDD:275380	11/25 (44%)
		leucine-rich repeat	371..394	CDD:275380	6/22 (27%)
		leucine-rich repeat	395..413	CDD:275380	4/17 (24%)
		LRRCT	429..477	CDD:214507	12/48 (25%)
		leucine-rich repeat	445..471	CDD:275380	4/25 (16%)
		IG	488..582	CDD:214652	25/106 (24%)
		Ig_1	603..677	CDD:143240
		I-set	680..759	CDD:369462
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910