DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Con and lrrc32.1

DIOPT Version :9

Sequence 1:	NP_001246635.1	Gene:	Con / 38590	FlyBaseID:	FBgn0005775	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	XP_004912272.1	Gene:	lrrc32.1 / 100489763	XenbaseID:	XB-GENE-994459	Length:	666	Species:	Xenopus tropicalis

Alignment Length:	557	Identity:	117/557 - (21%)
Similarity:	217/557 - (38%)	Gaps:	150/557 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 NNARLDYIPTMIIEPLKNLSSIVIEYSQVEIVKSYAFANLPFLERIILNNNHIMALDQDAFANHI 231
            :|..|..:| :.:.|  .:.::.:.::.:|.:.........|||.:.|::|.:..:...:|....
Frog    37 HNKSLQQVP-LDLPP--GIQTLDLSHNDLENITEDHLMKYSFLESLDLSSNQLSFIQPHSFRKMH 98

  Fly   232 RLRELNLEHNQIFEMDRYAFRN------LPLCERLFLNNNNISTLHEGLFADMA-RLTFLNLAHN 289
            :|:|:||..|   ::|.:....      ||..:.|.|:.|::.....|.|...| ||.:|:|..|
Frog    99 KLKEINLSGN---DLDSFVHHRVSGIGVLPYVQTLDLSRNSLYNDMIGYFLQEAPRLQYLSLHEN 160

  Fly   290 QINVLTSEIFRGLGNLNVLKLTRNNLNFIGDTVFAELWSLSELELDDNRIERISERALDGLNTLK 354
            .|..::|::|:|...|..:.|..|.:..|.:..|..|..||.::|..|.|..||:   ..|..||
Frog   161 SITTISSDLFQGSPLLAEVDLHNNIIMDIEEGSFEYLKHLSMIDLSMNSITCISD---FNLRQLK 222

  Fly   355 TLNLRNN--------------LLKKID--NGLLRGTPALLSINVQANKLETLTFYTFQPIMDNLV 403
            .|||..|              ||:|:|  :..|...|.|..:|   |.:       |..:..|.:
Frog   223 VLNLSKNSIKTFHTPDSEDEYLLEKVDLSHNKLSSFPQLPRVN---NVI-------FIDLSKNYI 277

  Fly   404 NSTSELLVSDNKFICDCRLQWIFELKNRTRHLQLRDSLEDLHCTLQEPKLSHF------VDPVP- 461
            :..:|....|.        .|:    |.:..|:..:.......|:..|||:|.      :..:|
Frog   278 HLGTETPGEDP--------DWM----NYSFQLEFEEQNPKNISTVPLPKLNHLDLSYNSIKSIPD 330

  Fly   462 ------PTI---------LDVLNIGGFTAIGSNSASMGGVGNSVVGSSYSGLTMDDSRKHLGSRS 511
                  |::         :.||::|.|:.: |:.|::....||:...|            ||:.|
Frog   331 DFFLTMPSLTFLNLSKNCIQVLSLGHFSGL-SSLATLDLSANSIQNLS------------LGANS 382

  Fly   512 RQALRGQRQFASSAE-NVVESKMRRRRKRQEEVKEKDLAAVAPAHKRYDYYDDNNGGM------- 568
            ..:|  ||.:....: .::|.::.:|           |.::...|.:.::......|:
Frog   383 LPSL--QRLYLQHNQLRLLEPRIFQR-----------LESIVLLHLQGNHVGPCMAGLGKAKRRT 434

  Fly   569 --------------SLGHGLDLDDNL--SLHKQGFYGAGSPVVGHNDVDVLMTSHSASGDALDIL 617
                          :|.| |:|.:|:  .:....|:|....|     :|:.|.        |.|.
Frog   435 HAEEYRCVEFFNIPTLQH-LNLRENMIQRIPASAFWGTSLKV-----LDLSMN--------LGIK 485

  Fly   618 TTKNAIY-----IKLFLLKPEMLPCHDELSDPTELPL 649
            ...||::     :::..::...||     |...:|||
Frog   486 VKPNALFGLEKTLEVLFMEGNGLP-----SLNVDLPL 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Con	NP_001246635.1	LRR_RI	<147..291	CDD:238064	30/130 (23%)
		LRR_8	183..243	CDD:290566	12/59 (20%)
		leucine-rich repeat	185..208	CDD:275380	1/22 (5%)
		leucine-rich repeat	209..232	CDD:275380	5/22 (23%)
		LRR_RI	<225..416	CDD:238064	57/213 (27%)
		LRR_8	232..291	CDD:290566	19/65 (29%)
		leucine-rich repeat	233..256	CDD:275380	7/28 (25%)
		leucine-rich repeat	257..280	CDD:275380	6/23 (26%)
		leucine-rich repeat	281..304	CDD:275380	8/22 (36%)
		LRR_8	304..363	CDD:290566	20/72 (28%)
		leucine-rich repeat	305..328	CDD:275380	6/22 (27%)
		leucine-rich repeat	329..352	CDD:275380	8/22 (36%)
		LRR_8	352..416	CDD:290566	19/79 (24%)
		leucine-rich repeat	353..376	CDD:275380	11/38 (29%)
		LRRCT	414..>450	CDD:214507	4/35 (11%)
lrrc32.1	XP_004912272.1	LRR_8	50..110	CDD:404697	13/64 (20%)
		leucine-rich repeat	52..75	CDD:275380	1/22 (5%)
		leucine-rich repeat	76..99	CDD:275380	5/22 (23%)
		PLN00113	99..>579	CDD:215061	106/492 (22%)
		leucine-rich repeat	100..151	CDD:275380	14/53 (26%)
		leucine-rich repeat	152..175	CDD:275380	8/22 (36%)
		leucine-rich repeat	176..199	CDD:275380	6/22 (27%)
		leucine-rich repeat	200..220	CDD:275380	8/22 (36%)
		leucine-rich repeat	245..314	CDD:275380	16/90 (18%)
		leucine-rich repeat	315..338	CDD:275380	3/22 (14%)
		leucine-rich repeat	339..362	CDD:275380	4/23 (17%)
		leucine-rich repeat	363..385	CDD:275380	7/33 (21%)
		leucine-rich repeat	386..409	CDD:275380	6/35 (17%)
		leucine-rich repeat	410..449	CDD:275380	2/38 (5%)
		leucine-rich repeat	450..472	CDD:275380	7/22 (32%)
		leucine-rich repeat	473..520	CDD:275380	13/63 (21%)
		leucine-rich repeat	498..512	CDD:275378	3/18 (17%)
		leucine-rich repeat	521..542	CDD:275380
		leucine-rich repeat	543..566	CDD:275380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45617
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010