DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment KRT12 and LamC

DIOPT Version :9

Sequence 1:NP_000214.1 Gene:KRT12 / 3859 HGNCID:6414 Length:494 Species:Homo sapiens
Sequence 2:NP_001260974.1 Gene:LamC / 36615 FlyBaseID:FBgn0010397 Length:640 Species:Drosophila melanogaster


Alignment Length:475 Identity:118/475 - (24%)
Similarity:194/475 - (40%) Gaps:96/475 - (20%)


- Green bases have known domain annotations that are detailed below.


Human   102 GGSPGGGSLGILSGNDGGLLS-GSEKETMQNLNDRLASYLDKVRALEEANTELENKIREWYETRG 165
            ||:.....:|..|.......| ..|||.:|:||||||.|:|::|.||..|:.|..::....:|..
  Fly    22 GGASTSSRVGATSPTSPTRTSRQQEKEELQHLNDRLACYIDRMRNLENENSRLTQELNLAQDTVN 86

Human   166 TGTADAS------------------------QSDYSKYYPLIEDLR----NKIISASIGNAQLLL 202
            ..|::..                        :.|..:.:...:||:    .|...|::..     
  Fly    87 RETSNLKAVYEKELAAARKLLDETAKEKAKLEIDIKRLWEENDDLKPRLDKKTKEATVAE----- 146

Human   203 QIDNARLAAEDF-------------RMKYEN---ELAL-RQGVEADINGLRRVLDELTLTRTDLE 250
              :||||....:             |.|:|:   |||| .:.:...::.||:.|:..||.|.|||
  Fly   147 --NNARLYENRYNEVNGKYNQSLADRKKFEDQAKELALENERLRRQLDDLRKQLEAETLARVDLE 209

Human   251 MQIESLNEELAYMKKNHEDELQSFRVGGPGEVSVEMDAAPG----VDLTRLLNDMRAQYETIAEQ 311
            .|.:||.||||:..:.|..||...|.....|:| |:|....    ..|.:.|.::|.|||.....
  Fly   210 NQNQSLREELAFKDQVHTQELTETRSRRQIEIS-EIDGRLSRQYEAKLQQSLQELRDQYEGQMRI 273

Human   312 NRKDAEAWFIEKSGELRKEISTNTEQLQSSKSEVTDLRRAFQNLEIELQSQLAMKKSLEDSLAEA 376
            ||::.|..:..:...|:...:...:....:..||..:|.....|..:||:.......|...:.|.
  Fly   274 NREEIELLYDNEIQNLKAAANRAAQGSALATEEVRLMRTKIDGLNAKLQNLEDTNAGLNARIREL 338

Human   377 EGDYCAQLSQVQQLISNLEAQLLQVRADAERQNVDHQRLLNVKARLELEIETYRRLLDGEAQGDG 441
            |.....:..:..|.|::|||:|.::|.:...|..::|.|:::|..|:|||..|.:||.||.:...
  Fly   339 ENLLDTERQRHNQYIASLEAELQRMRDEMAHQLQEYQGLMDIKVSLDLEIAAYDKLLCGEERRLN 403

Human   442 LEE-SLFVTDS---------KSQAQSTDSSKDPTKTR-------------KIKTVVQE------- 476
            :|. ....|||         .:.|.|......|:..|             :.:||:.|       
  Fly   404 IESPGRPTTDSGISSNGSHLTASASSRSGRVTPSGRRSATPGISGSSAVKRRRTVIDESEDRTLS 468

Human   477 --MVNG------EVVSSQVQ 488
              .||.      |::.:.|:
  Fly   469 EYSVNAAAKGDLEIIEADVE 488

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KRT12NP_000214.1 Head 1..124 5/22 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..32
Filament 124..436 CDD:278467 96/360 (27%)
Coil 1A 125..160 17/34 (50%)
Linker 1 164..182 2/41 (5%)
Coil 1B 183..274 34/111 (31%)
Linker 12 275..297 6/25 (24%)
Coil 2 298..435 36/136 (26%)
Tail 436..494 16/91 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 446..468 6/30 (20%)
LamCNP_001260974.1 Filament 45..401 CDD:278467 98/363 (27%)
ATP-synt_B <67..>142 CDD:304375 10/74 (14%)
MreC <178..>224 CDD:302802 20/45 (44%)
LTD 473..574 CDD:279300 3/16 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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