Protein Alignment KRT12 and Krt12

DIOPT Version :10

• Sequence 1: NP_000214.1
• Gene: KRT12 / 3859
• HGNCID: 6414
• Length: 494
• Species: Homo sapiens
• Sequence 2: NP_034791.2
• Gene: Krt12 / 268482
• MGIID: 96687
• Length: 487
• Species: Mus musculus
• Alignment Length: 489
• Identity: 388/489 - (79%)
• Similarity: 419/489 - (85%)
• Gaps: 4/489 - (0%)

Human     8 MSLSVRTPGLSRRLSSQS-VIGRPRGMSASSVGSGYGGSAFGFGASCGGGFSAASMFGSSSGFGG 71
            |||||.|..||||.|||: ..|||.|.|||||..||||||.|||..|||.|||||||||||||.|
Mouse     1 MSLSVCTSALSRRSSSQNGAAGRPWGASASSVAGGYGGSASGFGVGCGGLFSAASMFGSSSGFSG 65

Human    72 GSGSSMAGGLGAGYGRALGGGSFG-GLGMGFGGSPGGGSLGILSGNDGGLLSGSEKETMQNLNDR 135
            ||...:. |||:.||..|.||:.| |:|||..||.|||||.|.||||||||||||||||||||||
Mouse    66 GSAGCLP-GLGSAYGGPLRGGAGGMGIGMGIAGSSGGGSLCIFSGNDGGLLSGSEKETMQNLNDR 129

Human   136 LASYLDKVRALEEANTELENKIREWYETRGTGTADASQSDYSKYYPLIEDLRNKIISASIGNAQL 200
            |||||.|||:|||||.|||||||||||||.|..| .|||||||||||||||:|||:||.:.||||
Mouse   130 LASYLGKVRSLEEANAELENKIREWYETRRTRDA-GSQSDYSKYYPLIEDLKNKIVSARVSNAQL 193

Human   201 LLQIDNARLAAEDFRMKYENELALRQGVEADINGLRRVLDELTLTRTDLEMQIESLNEELAYMKK 265
            ||||||||||||||||||||||||||.|||||||||||||||||||.|||.|:|:|.||||||||
Mouse   194 LLQIDNARLAAEDFRMKYENELALRQTVEADINGLRRVLDELTLTRADLEAQLETLTEELAYMKK 258

Human   266 NHEDELQSFRVGGPGEVSVEMDAAPGVDLTRLLNDMRAQYETIAEQNRKDAEAWFIEKSGELRKE 330
            |||:|||||:.||||||:||||||||||||::||:||||||.:||||||||||||:|||.|||||
Mouse   259 NHEEELQSFQAGGPGEVNVEMDAAPGVDLTKVLNEMRAQYEAMAEQNRKDAEAWFLEKSRELRKE 323

Human   331 ISTNTEQLQSSKSEVTDLRRAFQNLEIELQSQLAMKKSLEDSLAEAEGDYCAQLSQVQQLISNLE 395
            ||:|||||||||||||||:|..||||||||||||||.|||.||||.||.||.|||||||||.:||
Mouse   324 ISSNTEQLQSSKSEVTDLKRMVQNLEIELQSQLAMKSSLEGSLAETEGGYCCQLSQVQQLIGSLE 388

Human   396 AQLLQVRADAERQNVDHQRLLNVKARLELEIETYRRLLDGEAQGDGLEESLFVTDSKSQAQSTDS 460
            .||.||||||||||.||||||.||||||:|||||||||:|::||||.:||..::.||.|..|.||
Mouse   389 EQLQQVRADAERQNADHQRLLGVKARLEMEIETYRRLLEGDSQGDGFDESSSLSVSKPQTPSVDS 453

Human   461 SKDPTKTRKIKTVVQEMVNGEVVSSQVQEIEELM 494
            ||||.|||||||||||:||||||||||||:||.|
Mouse   454 SKDPNKTRKIKTVVQEIVNGEVVSSQVQELEEEM 487

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KRT12	NP_000214.1	Head	1..124		80/117 (68%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..32		16/24 (67%)
		Filament	124..436	CDD:459643	264/311 (85%)
		Coil 1A	125..160		31/34 (91%)
		Linker 1	164..182		12/17 (71%)
		Coil 1B	183..274		78/90 (87%)
		Linker 12	275..297		18/21 (86%)
		Coil 2	298..435		115/136 (85%)
		Tail	436..494		41/57 (72%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	446..468		11/21 (52%)
Krt12	NP_034791.2	Head	1..118		80/117 (68%)
		Filament	118..428	CDD:459643	264/310 (85%)
		Coil 1A	119..154		31/34 (91%)
		Linker 1	158..175		12/17 (71%)
		Coil 1B	176..267		78/90 (87%)
		Linker 12	268..290		18/21 (86%)
		Coil 2	291..428		115/136 (85%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	428..461		18/32 (56%)
		Tail	429..487		41/57 (72%)