Protein Alignment Rh50 and RHBG

DIOPT Version :9

• Sequence 1: NP_001369039.1
• Gene: Rh50 / 38589
• FlyBaseID: FBgn0028699
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_065140.3
• Gene: RHBG / 57127
• HGNCID: 14572
• Length: 458
• Species: Homo sapiens
• Alignment Length: 459
• Identity: 205/459 - (44%)
• Similarity: 297/459 - (64%)
• Gaps: 23/459 - (5%)

  Fly     1 MHSPAAKVSGYVVLMIVQIIFL-----VLFWLFVRY-EKTALPLAIDAEDAGSANEHVSKYPQFQ 59
            |....::.:|..:.:.:..:||     |||.:|||| .||...|...:..:.:.||...:||.||
Human     1 MAGSPSRAAGRRLQLPLLCLFLQGATAVLFAVFVRYNHKTDAALWHRSNHSNADNEFYFRYPSFQ 65

  Fly    60 DIQVMIFIGFGFLMTFLRKYGYSATGFTLFMAALVVQWAVLMKGFLH-MEGGKISLSLENIIDAD 123
            |:..|:|:||||||.||::||:|:.|||..:||..:||:.|::|||| ..||.|.:.:|::|:||
Human    66 DVHAMVFVGFGFLMVFLQRYGFSSVGFTFLLAAFALQWSTLVQGFLHSFHGGHIHVGVESMINAD 130

  Fly   124 IAAAVPLISMGALLGRTTPIQLLCMSVFEVALFAANEYLALHVFSICDCGGSITVHAFGAYFGLA 188
            ..|...|||.||:||:|.|.|||.|::.||.||..||::.||:..:.|.|||:|:|.|||||||.
Human   131 FCAGAVLISFGAVLGKTGPTQLLLMALLEVVLFGINEFVLLHLLGVRDAGGSMTIHTFGAYFGLV 195

  Fly   189 VALML-RPASDQNETGKLEGASYTSDIFAMIGTTFLWVYWPSFNSVL-ADGAGGERAILNTFLSL 251
            ::.:| ||..::::  ..:|:.|.||:||||||.|||::|||||:.| |.|||..|..|||:.||
Human   196 LSRVLYRPQLEKSK--HRQGSVYHSDLFAMIGTIFLWIFWPSFNAALTALGAGQHRTALNTYYSL 258

  Fly   252 AAATVTTFVVSALVSHENKLDMVHVQNSTLAGGVAVGTVCNLLLGAHGAVLIGIIAGTVSVLGYR 316
            ||:|:.||.:||||..:.:|||||:||:.|||||.|||...::|...||:..|.:|||||.|||:
Human   259 AASTLGTFALSALVGEDGRLDMVHIQNAALAGGVVVGTSSEMMLTPFGALAAGFLAGTVSTLGYK 323

  Fly   317 YLTPWMTANLRLHDTCGVHNLHGMPALISAIASAIYASMATVGEYQSELQDIFPAMVGTNGTETK 381
            :.||.:.:..::.||||||||||||.::.|:...:.|.:||...|...|:.:||.:....
Human   324 FFTPILESKFKVQDTCGVHNLHGMPGVLGALLGVLVAGLATHEAYGDGLESVFPLIAEGQ----- 383

  Fly   382 IMGGLGRNATSQAGYQLFGIAVTLLIAIGGGILTGAVLKYTNFRNLKKDEHHQDEHYWEVPAA-E 445
                  |:|||||.:||||:.|||:.|..||.|.|.:||.....:....:|::|:.:|:||.. |
Human   384 ------RSATSQAMHQLFGLFVTLMFASVGGGLGGLLLKLPFLDSPPDSQHYEDQVHWQVPGEHE 442

  Fly   446 NKEE 449
            :|.:
Human   443 DKAQ 446

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rh50	NP_001369039.1	Ammonium_transp	55..422	CDD:413553	182/369 (49%)
RHBG	NP_065140.3	Ammonium_transp	61..360	CDD:275788	155/300 (52%)
		Interaction with ANK3. /evidence=ECO:0000269|PubMed:15611082	416..424		1/7 (14%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159976
Domainoid	1	1.000	375	1.000	Domainoid score	I876
eggNOG	1	0.900	-	-		E1_KOG3796
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9469
Inparanoid	1	1.050	376	1.000	Inparanoid score	I2098
Isobase	1	0.950	-	0	Normalized mean entropy	S2906
OMA	1	1.010	-	-		QHG54631
OrthoDB	1	1.010	-	-		D311058at33208
OrthoFinder	1	1.000	-	-		FOG0000589
OrthoInspector	1	1.000	-	-		otm40435
orthoMCL	1	0.900	-	-		OOG6_101421
Panther	1	1.100	-	-	LDO	PTHR11730
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5299
SonicParanoid	1	1.000	-	-		X200
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	16	15.790