DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rh50 and RHCG

DIOPT Version :9

Sequence 1:	NP_001369039.1	Gene:	Rh50 / 38589	FlyBaseID:	FBgn0028699	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001307970.1	Gene:	RHCG / 51458	HGNCID:	18140	Length:	479	Species:	Homo sapiens

Alignment Length:	452	Identity:	195/452 - (43%)
Similarity:	292/452 - (64%)	Gaps:	35/452 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 MIVQIIFLVLFWLFVRY----------EKTALPLAIDAEDAGSANEHVSKYPQFQDIQVMIFIGF 69
            :::|:|.::||.:||||          |:|...|: |.|     ||...:||.|||:.||:|:||
Human    16 LLLQVIMVILFGVFVRYDFEADAHWWSERTHKNLS-DME-----NEFYYRYPSFQDVHVMVFVGF 74

  Fly    70 GFLMTFLRKYGYSATGFTLFMAALVVQWAVLMKGFLH-MEGGKISLSLENIIDADIAAAVPLISM 133
            |||||||::||:||.||...:||..:|||:||:|:.| ::...|.:.:||:|:||...|...::.
Human    75 GFLMTFLQRYGFSAVGFNFLLAAFGIQWALLMQGWFHFLQDRYIVVGVENLINADFCVASVCVAF 139

  Fly   134 GALLGRTTPIQLLCMSVFEVALFAANEYLALHVFSICDCGGSITVHAFGAYFGLAVA-LMLRPAS 197
            ||:||:.:|||||.|:.|:|.|||.||::.|::..:.|.|||:|:|.|||||||.|. ::.|...
Human   140 GAVLGKVSPIQLLIMTFFQVTLFAVNEFILLNLLKVKDAGGSMTIHTFGAYFGLTVTRILYRRNL 204

  Fly   198 DQNETGKLEGASYTSDIFAMIGTTFLWVYWPSFNSVLA-DGAGGERAILNTFLSLAAATVTTFVV 261
            :|::  :.:.:.|.||:||||||.|||:|||||||.:: .|....||.:||:.||||..:|:..:
Human   205 EQSK--ERQNSVYQSDLFAMIGTLFLWMYWPSFNSAISYHGDSQHRAAINTYCSLAACVLTSVAI 267

  Fly   262 SALVSHENKLDMVHVQNSTLAGGVAVGTVCNLLLGAHGAVLIGIIAGTVSVLGYRYLTPWMTANL 326
            |:.:..:.||||||:||:||||||||||...::|..:||::||.:.|.:|.||:.||||::.:.|
Human   268 SSALHKKGKLDMVHIQNATLAGGVAVGTAAEMMLMPYGALIIGFVCGIISTLGFVYLTPFLESRL 332

  Fly   327 RLHDTCGVHNLHGMPALISAIASAIYASMATVGEYQSE-LQDIFPAMVGTNGTETKIMGGLGRNA 390
            .:.||||::||||:|.:|..|..|:.|:.|::..|..| |...|. ..|.||..|         |
Human   333 HIQDTCGINNLHGIPGIIGGIVGAVTAASASLEVYGKEGLVHSFD-FQGFNGDWT---------A 387

  Fly   391 TSQAGYQLFGIAVTLLIAIGGGILTGAVLKYTNFRNLKKDEH-HQDEHYWEVPAAENKEEYL 451
            .:|..:|::|:.|||.:|:.|||:.|.:|:.. |.....||: .:|..|||:|.. |...|:
Human   388 RTQGKFQIYGLLVTLAMALMGGIIVGLILRLP-FWGQPSDENCFEDAVYWEMPEG-NSTVYI 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rh50	NP_001369039.1	Ammonium_transp	55..422	CDD:413553	170/370 (46%)
RHCG	NP_001307970.1	Ammonium_transp	60..435	CDD:322161	174/387 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159975
Domainoid	1	1.000	375	1.000	Domainoid score	I876
eggNOG	1	0.900	-	-		E1_KOG3796
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	376	1.000	Inparanoid score	I2098
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54631
OrthoDB	1	1.010	-	-		D311058at33208
OrthoFinder	1	1.000	-	-		FOG0000589
OrthoInspector	1	1.000	-	-		otm40435
orthoMCL	1	0.900	-	-		OOG6_101421
Panther	1	1.100	-	-	O	PTHR11730
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X200
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.770