DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dnah3 and DNAH11

DIOPT Version :9

Sequence 1:	NP_647937.2	Gene:	Dnah3 / 38586	FlyBaseID:	FBgn0035581	Length:	4385	Species:	Drosophila melanogaster
Sequence 2:	NP_001264044.1	Gene:	DNAH11 / 8701	HGNCID:	2942	Length:	4516	Species:	Homo sapiens

Alignment Length:	4748	Identity:	1322/4748 - (27%)
Similarity:	2147/4748 - (45%)	Gaps:	823/4748 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 KLRRKRTLHLPRVSQAQKKGEKRQLNDCPFYN--LTYGFDQLPLDPVKEFLQEKISHMQTDKIVG 83
            |:.|:..|.:|.|:......:....|..|...  :.:..:.:.::...: :||.|......:::.
Human   205 KMSRRTLLPIPTVAGKMDLDQNCSENKPPSNERIILHAIESVVIEWSHQ-IQEIIERDSVQRLLN 268

  Fly    84 --HCN--REFDFHRYDLDNVKDEYDECDDDSLQEL-------------QLEDIIM--------PE 123
              |.:  .|.||.....:|:...||:.....:.::             .|:||.:        .:
Human   269 GLHLSPQAELDFWMMRRENLSCIYDQLQAPVVLKMVKILTTKQSSYFPTLKDIFLAVENALLEAQ 333

  Fly   124 QFEM-LRDAKDHLYNFDSTACNQFPWIDKWMTGVRPSEQEIYEMTSH------------LLEIYC 175
            ..|: ||..:.|:.....|   :||   :....:.|....|..:.||            ||:.:|
Human   334 DVELYLRPLRRHIQCLQET---EFP---QTRILIAPLFHTICLIWSHSKFYNTPARVIVLLQEFC 392

  Fly   176 NRRVRIFYPGCGTSSSLWTNQLRRQHGSPSELIGAYRTPSARHMRV---------NNMRGPPKKE 231
            |               |:.|| ...:.||.:|:......|...::|         |:.....||
Human   393 N---------------LFINQ-ATAYLSPEDLLRGEIEESLEKVQVAVNILKTFKNSFFNYRKK- 440

  Fly   232 KFTAGDHYAFR--TPQECRNELM--RVGKIIDELIE------------------------PVLKA 268
               ...::..|  .|.:.::.|:  |..|.:|.||:                        .:|..
Human   441 ---LASYFMGRKLRPWDFQSHLVFCRFDKFLDRLIKIEDIFATTLEFEKLERLEFGGTKGAILNG 502

  Fly   269 AEHKIGHGL---------TKYPDPPSC------------KDNTNRILRSAGILVGKKKNCYVGKC 312
            ..|::...|         :.| ||..|            |..|....|..|.::          |
Human   503 QVHEMSEELMELCKLFKQSTY-DPSDCTNMEFESDYVAFKSKTLEFDRRLGTII----------C 556

  Fly   313 RIHRKDFATNEEFLRCLKRMEA-----THF-PYMQPLQPVDPDDQKI---KMLAKYRVELARAEK 368
                      |.|..| ..:||     |.| .:::  :||..:...:   .::..:..||...::
Human   557 ----------EAFFNC-NGLEAAFKLLTIFGNFLE--KPVVMEIFSLHYSTLVHMFNTELDVCKQ 608

  Fly   369 LFTLKIQKRYQC----LLKSMS------------IVQLATYPSHL--IRKAFRRINPRSALLQDA 415
            |:. :..|:.:|    |.|:|.            :.:|..:.|:.  :|..|.. ||..||:...
Human   609 LYN-EHMKQIECGHVVLNKNMPFTSGNMKWAQQVLQRLQMFWSNFASLRYLFLG-NPDHALVYQK 671

  Fly   416 Y--------QFIVKEKRDWPKLPPEVILMDYLFVGDRGVRQDLAILIIVCLIDLQEDFRHYVKRS 472
            |        ||..:...:|.....|                       :|..:|.:..   ||.|
Human   672 YVEMTTLLDQFESRIYNEWKSNVDE-----------------------ICEFNLNQPL---VKFS 710

  Fly   473 FLNYLLSSNMERRRLQLEREP-----------PEFPILTISPPVSWRSNLLRGKARIGEVLMTTH 526
            .:|.||..|.:.:.:.:.||.           |:..:.....    |:.:|:   .||.:.:
Human   711 AINGLLCVNFDPKLVAVLREVKYLLMLKKQDIPDSALAIFKK----RNTILK---YIGNLDL--- 765

  Fly   527 PTVQALNRLWHDLYEDLVVVDLGQLLLAQRPLDADTVQVFIEKSCADVRDLLLNDWLPRC----- 586
             .||..|:|...|.|            .:.||..|.::...|:..|....|   .|...|
Human   766 -LVQGYNKLKQTLLE------------VEYPLIEDELRAIDEQLTAATTWL---TWQDDCWGYIE 814

  Fly   587 ------ADLMNEMRGTWKDLVPMSGKYGGRAAMLFRCIHSAMSRHLNSLISKSINYLFKVLCAFK 645
                  ::|.:.:..|.|::..:.....|.|    ||:......|...             .||
Human   815 RVRAATSELEHRVERTQKNVKVIQQTMRGWA----RCVLPPRREHRRE-------------AAF- 861

  Fly   646 GGNRIEKYSMFDAKLKRIPLMTLIASVVGAHFDHEPINMGPGVRPASNIYVYDEDDADPFQ-QPQ 709
              ...:|..:|..|.|.|                    .|.|.:    |:...|::...|: .|.
Human   862 --TLEDKGDLFTKKYKLI--------------------QGDGCK----IHNLVEENRKLFKANPS 900

  Fly   710 VNQFVENVPDIDDVA------------QFELDHSNK-LYIYPYMQE----LPRIFTEHFKSILAV 757
            ::.:...|..|||:.            .|.|.::.| |...|:.|.    ||
Human   901 LDTWKIYVEFIDDIVVEGFFQAIMHDLDFFLKNTEKQLKPAPFFQAQMILLP------------- 952

  Fly   758 GYEIPRLEFVMSGGEPETKGFLHFIDE--------------------------DHVDFLELCEKV 796
                |.:.|..|.......||...::|                          |..:.|.|.|..
Human   953 ----PEIVFKPSLDREAGDGFYDLVEEMLCNSFRMSAQMNRIATHLEIKNYQNDMDNMLGLAEVR 1013

  Fly   797 EQIV--------KV----NWQGVHVYL----KPVYKYYFGLFQKLILPMVQKVWTENNLPELGAV 845
            ::|:        ||    |....|.||    :..:..:|.|:...:............:||....
Human  1014 QEIMNRVVNVINKVLDFRNTLETHTYLWVDDRAEFMKHFLLYGHAVSSDEMDAHANEEIPEQPPT 1078

  Fly   846 QELLKKLQAVSDTTYY----LRDF-IPLNLFMLDNRHVKLSLR--------MYVREIYDFIIDFY 897
            .|..|:...:.:..|.    ..|| :..:.|.:|.:..|:||.        |:...:..|:||
Human  1079 LEQFKEQIDIYEALYVQMSKFEDFRVFDSWFKVDMKPFKVSLLTIIKKWSWMFQEHLLRFVID-- 1141

  Fly   898 KALNWNENRAICEELEEMSMKAGERPEETPEVVALQNYINDCRE-------MRIFAIK------D 949
             :||         ||:|..       :||..  .||..:|:...       :.:.|::      |
Human  1142 -SLN---------ELQEFI-------KETDS--GLQRELNEGDHDGLVDIMVHLLAVRSRQRATD 1187

  Fly   950 EIKNVLKRVVFLL--------THTYLSSDELHLNSRTF--ILPGELEEVLDLSAARLAVVR---- 1000
            |:...||..:.||        ...|:..:||.....|.  |......||..|..|.:.::|
Human  1188 ELFEPLKETITLLESYGQKMPEQVYIQLEELPERWETTKKIAATVRHEVSPLHNAEVTLIRKKCI 1252

  Fly  1001 --DNLELALRERRMEFEKLLAQEKRTMDGFRIREIRDVLTLEELKERVDTVDLLFTTIENLSREA 1063
              |..:...|||...:..|         ||                   ..:..:|.::..:.|.
Human  1253 LFDAKQAEFRERFRHYAPL---------GF-------------------NAENPYTALDKANEEL 1289

  Fly  1064 KAINTEETLLQIDVSA---------FPLLAEIIEKMEPIEKLWKTSYEFEKDYLIWMFERFECLN 1119
            :|:  ||.:||:..|.         :..:.:..::::.::.||        |.:|:
Human  1290 EAL--EEEMLQMQESTRLFEVALPEYKQMKQCRKEIKLLKGLW--------DVIIY--------- 1335

  Fly  1120 ADGVREQVENMHKIMYKLSRQLAYNPVAKRAAEQMRMKIEKF-----------RVY--------- 1164
               ||..::|..|..:   ||:        ..|||.:::.:|           ||:
Human  1336 ---VRRSIDNWTKTQW---RQI--------HVEQMDVELRRFAKEIWSLNKEVRVWDAYTGLEGT 1386

  Fly  1165 -------LPVLDSICRHGLEKRHWDQISKILGRKVNPKLFPTLKDMIDVDIMSILPQLEEIANAA 1222
                   |..:..:....|..|||.|:.|.:|.|.......||.|::.:.:..:...:..|.:.|
Human  1387 VKDMTASLRAITELQSPALRDRHWHQLMKAIGVKFLINEATTLADLLALRLHRVEDDVRRIVDKA 1451

  Fly  1223 GKEYDLNNGLRIMQADWRDVMFEVLQYRDSDTHILASLDDIQTLLDDHIMRTQAMKRSPFITALG 1287
            .||......:..:...|..:.|....:..:...:|.|.:.:...|:.:.::.|.:.:|.::....
Human  1452 VKELGTEKVITEISQTWATMKFSYEVHYRTGIPLLKSDEQLFETLEHNQVQLQTLLQSKYVEYFI 1516

  Fly  1288 SKADDWEARLLLIQNIIDAWTQVQITWMYLEPIF-SSEDIMRQMPLEGRNFKAVDKLWRKIMKHT 1351
            .:...|:.:|.:...:|..|.:||.||.:||.|| .||||..|:..:.|.|..||..::::|..|
Human  1517 EQVLSWQNKLNIADLVIFTWMEVQRTWSHLESIFVCSEDIRIQLVKDARRFDGVDAEFKELMFKT 1581

  Fly  1352 LKDRHVMAATEYPEMLEVFTKAIEDLETVTKGLNTYLEQKRLFFARFFFLSNDELLEILSETKDP 1416
            .|..:|:.||..|.:.|........|....|.|..|||.||:.|.||:|:|:.:||:|||:...|
Human  1582 AKVENVLEATCRPNLYEKLKDLQSRLSLCEKALAEYLETKRIAFPRFYFVSSADLLDILSKGAQP 1646

  Fly  1417 MRVQPHLRKCFEGIGSLTFDDNMEI-----VEMVSDEEERVALVRKINPQLANGLVEMWLKEVEM 1476
            .:|..||.|.|:.|..|.|:||.::     |.|.|.|:|.|....:..   ..|.||.||.::|.
Human  1647 KQVTCHLAKLFDSIADLQFEDNQDVSAHRAVGMYSKEKEYVPFQAECE---CVGHVETWLLQLEQ 1708

  Fly  1477 VMLDSVKEQMREAWEDYAMVERISWVVSWPGQVVQGISCMAWTYEV-------EEAIETKELPAY 1534
            .|.::|:..:.||...|....|..|:..:|.||....|.:.||.:|       ||..|| .|..:
Human  1709 TMQETVRHSITEAIVAYEEKPRELWIFDFPAQVALTSSQIWWTTDVGIAFSRLEEGYET-ALKDF 1772

  Fly  1535 LEKSNLQIADLVQLVRTDLQAGVRIAVEALIVLDVHDRDVVKYLTDCRITNIQDFDWISQLRYYW 1599
            .:|...|:..|:.|:..:|..|.|..:..:..:|||.||||..|...::.:.|.|.|:||||:.|
Human  1773 HKKQISQLNTLITLLLGELPPGDRQKIMTICTIDVHARDVVAKLISQKVVSPQAFTWLSQLRHRW 1837

  Fly  1600 KVNEKNEDWVC-VSMVVTDVEYGMEYLGNLPRLVVTPLTDRCYRTLMGALKLCLGGAPEGPAGTG 1663
            :..:|:    | |::.....:|..|||||.||||:||||||||.||..:|.|.:.|||.||||||
Human  1838 EDTQKH----CFVNICDAQFQYFYEYLGNSPRLVITPLTDRCYITLTQSLHLTMSGAPAGPAGTG 1898

  Fly  1664 KTETCKDLAKAVAKKCVVFNCSDGLDYKALGKFFKGLAQSGAWACFDEFNRIELEVLSVVAQQIL 1728
            ||||.|||.:|:.....|||||:.:|||::|..:|||.|:|||.||||||||.:|||||||.|:.
Human  1899 KTETTKDLGRALGMMVYVFNCSEQMDYKSIGNIYKGLVQTGAWGCFDEFNRISVEVLSVVAVQVK 1963

  Fly  1729 TIQRAIGRKVVKFFFEDTMLKLDPTCSIFITMNPGYAGRTELPDNLKVLFRTVAMMVPDYAMIGE 1793
            .|..||..:..:|.|....:.|.|:..||||||||||||||||:|||.|||..||:.||..:|.|
Human  1964 MIHDAIRNRKKRFVFLGEAITLKPSVGIFITMNPGYAGRTELPENLKALFRPCAMVAPDIELICE 2028

  Fly  1794 ITLYSNGFDMARNLSQKIVQAYKLCSEQLSSQSHYDYGMRAVKSVLLASASLRRLYVDLPEPEIV 1858
            |.|.:.||..||.|::|.:..|.||.|.||.|.|||:|:||:||||:.:.||:|...:.||.:::
Human  2029 ILLVAEGFVDARALARKFITLYTLCKELLSKQDHYDWGLRAIKSVLVVAGSLKRGDKNRPEDQVL 2093

  Fly  1859 LRAIVDVNLPKFLEQDISLFIGIYMDLFPGVELPMPQRGDILKWLHINLADRNLQATPWYLEKIL 1923
            :||:.|.|:||.:..||.:|:|:..||||.:::|..::....:.:..:..:..||....::.|::
Human  2094 MRALRDFNMPKIVTDDIPVFLGLVGDLFPALDVPRRRKLHFEQMVRQSTLELRLQPEESFILKVV 2158

  Fly  1924 QIYEMLLVRHGLMIVGGSMGGKTTAYQVLAQTLRNVSTDEEATLKEFPVTFRIINPKAITMGQLY 1988
            |:.|:|.|||.:.:||.:..||:...:.|.:|..|        :|:.|| :..:||||:|..:|:
Human  2159 QLEELLAVRHSVFVVGNAGTGKSKILRTLNRTYVN--------MKQKPV-WNDLNPKAVTTDELF 2214

  Fly  1989 GRFDPVSHEWYDGVLAKTF---------REQV----QGPKGERAWVMFDGPVDAVWIENLNTVLD 2040
            |.....:.||.||.:..::         |||.    .|||    |::.||.:|.:|||:||||:|
Human  2215 GFIHHATREWKDGKIVYSYFIGLFSSILREQANLKHDGPK----WIVLDGDIDPMWIESLNTVMD 2275

  Fly  2041 DNKKLCLMSGEIMQMTKLMNMMFEPADLEQASPATVSRCGMIYMEPSQLGW---------RALH- 2095
            |||.|.|.|.|.:.:|..|.::||...|..|:||||||.|::|:.|..|||         |..|
Human  2276 DNKVLTLASNERIALTPFMRLLFEIHHLRSATPATVSRAGILYVNPQDLGWNPYVASWIDRRRHQ 2340

  Fly  2096 --KSFINVLVNKV--GLGDIYMTLFEDMTEWLVPAA---------LEFLPQCKQMLELSPIYQYQ 2147
              |:.:.:|.:|.  ...|...|.|:.:|.  :|.:         ||.|...:.:...||...|:
Human  2341 SEKANLTILFDKYVPACLDKLRTSFKTITS--IPESSLVQTLCVLLECLLTPENVPSDSPKEVYE 2403

  Fly  2148 TFSRFFLHFLEKHKQFNQAWFQQMFLFCFAWAYCSAL----TGQGQKTFDALLRKVIYGSNENFP 2208
            .:                      |:|...||:...|    ....|..|....:|.:
Human  2404 VY----------------------FVFACIWAFGGTLLQDQISDYQADFSRWWQKEM-------- 2438

  Fly  2209 KPKYFSLNRGQMFPEKLLFLDYRFD-EAENWWTWQKSDDSASTTSNFPENAQISELIVPTKETGY 2272
                    :...||.:....||..| :.:....|  :|..|..|.:  .:..:..::|.|.||..
Human  2439 --------KAVKFPSQGTIFDYYVDHKTKKLLPW--ADKIAQFTMD--PDVPLQTVLVHTTETAR 2491

  Fly  2273 ISYWQEFCISKSYAMLVVGPTGTGKSAIITSNLLAMPKFANLVNVINFSARTSAQMVQDTIMSKL 2337
            :.|:.|..:.|...:::||..|.||:..:...|.::.: ..:|:.:.|:..|::..:|..:...|
Human  2492 LRYFMELLLEKGKPLMLVGNAGVGKTVFVGDTLASLSE-DYIVSRVPFNYYTTSTALQKILEKPL 2555

  Fly  2338 DRRRKGVFGPSLGKKCTVFCDDVAMPSKDTYGSQAPLELLRTWLDHGYWSDLVDTTKIELVDMTL 2402
            :::....:||...||...|.||:.||..|.||:..|..|:|..:|:|:|.|.......|:.:...
Human  2556 EKKAGHNYGPGGNKKLIYFIDDMNMPEVDLYGTVQPHTLIRQHIDYGHWYDRQKVMLKEIHNCQY 2620

  Fly  2403 MCAMGTLGGSNFIFPRLYRHMFVVAVDSFEDSTIVRIFTTIGDWHF-SKGYPEKVALLSRGLSEA 2466
            :..|..:.||..|.|||.||..|.|.:......:..|:..|..:|| .:.:...:......|.:|
Human  2621 VACMNPMVGSFTINPRLQRHFTVFAFNFPSLDALNTIYGQIFSFHFQQQAFAPSILRSGPTLIQA 2685

  Fly  2467 MVSVYRDAIRSFLPTPAKSHYSFSLRDITRVFQGIVMVPPKRMPDPEKLGRLWAHETYRVFYDRL 2531
            .::.::..:.:||||..|.||.|:|||::.|||||:...|:.:..|..|..||.||:.||:.|:|
Human  2686 TIAFHQTMMCNFLPTAIKFHYIFNLRDLSNVFQGILFASPECLKGPLDLIHLWLHESARVYGDKL 2750

  Fly  2532 VDQQDRDRLLVMAVDACKSNLRFPLEQAFG--ERIEPGEKLTDNDLRNLFYGNYMEPDAEPKFYD 2594
            :|::|           |....|..||.|:.  |.|:....|.    :.|.|.::.:...:|.:..
Human  2751 IDKKD-----------CDLFQRRMLETAYKYFEGIDSHMLLQ----QPLIYCHFADRGKDPHYMP 2800

  Fly  2595 EGDTYEKLEKLMKYYLREYNSFSSTPMDLVMFRFAIEHVSRVSRVLQMPRGNILMVGMGGSGRRS 2659
            ..| :|.|:.::...|..||..::. |.||:|..|::||.|:||:|:.|:|..|:||:||||::|
Human  2801 VKD-WEVLKTILTETLDNYNELNAA-MHLVLFEDAMQHVCRISRILRTPQGCALLVGVGGSGKQS 2863

  Fly  2660 SARLAAYIADCRLMTVQVSKSYTITDWRDDLKKILMSASFNLNHTVFLFSDAQATDEGYVEDING 2724
            .:|||||:....:..:.:::.|.|.:.|.||..:.:........||||.:|||..||.::..||.
Human  2864 LSRLAAYLRGLEVFQITLTEGYGIQELRVDLANLYIRTGAKNMPTVFLLTDAQVLDESFLVLIND 2928

  Fly  2725 ILNTGDLPNLYQLEDKATIMENMANVAKQLGKILDTLPSEVYAYYIDRIREQLHIALAFSPIGDS 2789
            :|.:|::|:|:..||...|:..:.|....|| ::|: ....:.:::.|:|.||.|.|.|||:|.:
Human  2929 LLASGEIPDLFSDEDVDKIISGIHNEVHALG-MVDS-RENCWKFFMARVRLQLKIILCFSPVGRT 2991

  Fly  2790 FKERIRVYPSLINCCTIDWYMPWPEEALSRVGVYFVSSMNLNRPHGEETQEPVQSKDAADPDEEE 2854
            .:.|.|.:|:::||..|||:..||:|||..|...|:
Human  2992 LRVRARKFPAIVNCTAIDWFHAWPQEALVSVSRRFI----------------------------- 3027

  Fly  2855 VRRETVGVEREQTQLEADLVDCVM-YFHQSVVDASEKCYLELNRRNYVTPSAYLELLKAFRTFYT 2918
              .||.|:|    .:..|.:...| :.|.:|.:.|.:.|....|.||.||.::||.:..|:....
Human  3028 --EETKGIE----PVHKDSISLFMAHVHTTVNEMSTRYYQNERRHNYTTPKSFLEQISLFKNLLK 3086

  Fly  2919 RKLDEITRLRDRYTTGLEKLDFAAGQVGEMQTNLYDLQPKLKVLSEETDRIMVNIERETAEAEKK 2983
            :|.:|::..::|...|::||...|.|||:::..|...:.:|::.:.:.:.::..|..:|.:..::
Human  3087 KKQNEVSEKKERLVNGIQKLKTTASQVGDLKARLASQEAELQLRNHDAEALITKIGLQTEKVSRE 3151

  Fly  2984 KEVVGADEAAANEAAAAAQAIKDDCETDLAEAIPAMEAALEALNTLKPADIFIVKSMKNPPYGVK 3048
            |.:..|:|.............:.:||.||.:|.||:.||..|||||...::..:|:..|||..|.
Human  3152 KTIADAEERKVTAIQTEVFQKQRECEADLLKAEPALVAATAALNTLNRVNLSELKAFPNPPIAVT 3216

  Fly  3049 LTMEAVCVIRGIKPDRKPDPSGHMVED-YWGPS---MRMLSDMKFLDSLKTFDKDNIPPPIIKRI 3109
            ....||.|:..        |.|.:.:| .|..:   |..:.|  ||.:|..:||::||...:|.:
Human  3217 NVTAAVMVLLA--------PRGRVPKDRSWKAAKVFMGKVDD--FLQALINYDKEHIPENCLKVV 3271

  Fly  3110 REKYIADRDFVPEKIKAASMACEGICRWVRAMDVYDKVARIVMPKKAALAEAEGELSQQMEKLNA 3174
            .|.|:.|.:|.|..|:..|.|..|:|.||..:..:.:|...|.||:.|||:|..||:...|||.|
Human  3272 NEHYLKDPEFNPNLIRTKSFAAAGLCAWVINIIKFYEVYCDVEPKRQALAQANLELAAATEKLEA 3336

  Fly  3175 KRAELQVILDK-LQKLNDFFAEKSREKKRLEDEIDNCEKKLNRAEKLLGGLGGEKTRWSEAAKNL 3238
            .|.:| |.||: |.:|...|.:.:.||.|.::|::...|.:..|.:|:..|..:|.||.::.|:.
Human  3337 IRKKL-VDLDRNLSRLTASFEKATAEKVRCQEEVNQTNKTIKLANRLVKELEAKKIRWGQSIKSF 3400

  Fly  3239 HESISNIVGDVLLAGGCTAYLGYFTTEYRVNILD-DWNALCKRK-HIPSSETFSLATTLGHPMTI 3301
            ......:.|||||.....:|:|.||.:||..::. .|....::| .||.:|...|.:.|....||
Human  3401 EAQEKTLCGDVLLTAAFVSYVGPFTRQYRQELVHCKWVPFLQQKVSIPLTEGLDLISMLTDDATI 3465

  Fly  3302 RAWSLAGLPADNFSVENGIIVTNSSRYSLLIDPQVQANKWIKNMEKNNNLKVIKQSDANYMQVLE 3366
            .||:..|||:|..|.||..|:|:..|:.|:||||.|..||||| :...:|||.......::..:|
Human  3466 AAWNNEGLPSDRMSTENAAILTHCERWPLVIDPQQQGIKWIKN-KYGMDLKVTHLGQKGFLNAIE 3529

  Fly  3367 LAITFGQPVLIENVGEKLDSNLTPILEKNVIKHKGGLFIKSGDQMIEYNPNFRLYITTCLRNPRY 3431
            .|:.||..:||||:.|.:|..|.|:|.:|.||.  |.:|:.||:..|:|.||||.:.|.|.||.|
Human  3530 TALAFGDVILIENLEETIDPVLDPLLGRNTIKK--GKYIRIGDKECEFNKNFRLILHTKLANPHY 3592

  Fly  3432 PPEVMVMVTVLNFMITEQGLREQLLAIVVAHERPDLQEKKEQLIIESARNRDALYTIESKILE-- 3494
            .||:....|:|||.:||.||..||||.||:.|||||::.|  |::...:|.   :.||.|.||
Human  3593 KPELQAQTTLLNFTVTEDGLEAQLLAEVVSIERPDLEKLK--LVLTKHQND---FKIELKYLEDD 3652

  Fly  3495 ---VLSTSEGNVLEDENAINILSSSKILSEDIQEKQVIAVATEIEIDAARQQYIPVSKHSAILFF 3556
               .||.:||:.|:|...:..|.::|....:|:.|.:.|...|.:|:.||:.|.||:..:::|:|
Human  3653 LLLRLSAAEGSFLDDTKLVERLEATKTTVAEIEHKVIEAKENERKINEARECYRPVAARASLLYF 3717

  Fly  3557 CISELANVDPMYQYSLSWFLNLFVNTILKAPKSDQLSERLKNLNDYFTKSIYTNVCRSLFEKDKL 3621
            .|::|..::|:||:||..|..||...|.:|.|.:.:..|:..|.:..|.:::....::|||||||
Human  3718 VINDLQKINPLYQFSLKAFNVLFHRAIEQADKVEDMQGRISILMESITHAVFLYTSQALFEKDKL 3782

  Fly  3622 VISLVMCLGILVSQGRVEKAALLFFLTGGIGYKTIPPNPLGAWLPDKSWASVCKAADLEGLKNLP 3686
            .....|...||:.:..::...|.|.|...:.:..:.|..   :|..:||:::...|.:|..:.:.
Human  3783 TFLSQMAFQILLRKKEIDPLELDFLLRFTVEHTHLSPVD---FLTSQSWSAIKAIAVMEEFRGID 3844

  Fly  3687 QMMETYSDEWHNFYDASNPDQLQLPAPHNTVNDMYFLIVIKSLRPDKLVPAVRAFITRNLDRSFV 3751
            :.:|..:.:|..:.::..|::.:||......:.:..||:::::|||::..|:|.|:...|...:|
Human  3845 RDVEGSAKQWRKWVESECPEKEKLPQEWKKKSLIQKLILLRAMRPDRMTYALRNFVEEKLGAKYV 3909

  Fly  3752 EPPPFDLAASFADSSPKIPLVFLLSAGSDPMASLFMFAKQRNM---YDKLKTISLGQGQGPRAEK 3813
            |....||..:|.:|||..|:.|:||.|.|.:..|.:..|:...   ..|...:||||||...||.
Human  3910 ERTRLDLVKAFEESSPATPIFFILSPGVDALKDLEILGKRLGFTIDSGKFHNVSLGQGQETVAEV 3974

  Fly  3814 MIMEAARHGQWVVLQNCHVAISWMGDLERICNDTTLTDGANHDYRLWCT--SYPSA---VFPVSV 3873
            .:.:|::.|.||:|||.|:...|:|.||::..  ..:.|::.|||::.:  |.|:.   :.|..:
Human  3975 ALEKASKGGHWVILQNVHLVAKWLGTLEKLLE--RFSQGSHRDYRVFMSAESAPTPDEHIIPQGL 4037

  Fly  3874 LQNSVKMTNEPPKGLRANMHR---SFTSDPL---MRDKFFTNAFLFSDSANKCWLRGVFALVFFH 3932
            |:||:|:|||||.|:.||:|.   :|..|.|   .:::.|.:.              :|:|.:||
Human  4038 LENSIKITNEPPTGMLANLHAALYNFDQDTLEICSKEQEFKSI--------------LFSLCYFH 4088

  Fly  3933 AVVQERREFGPLGWNIPYEFNESDLKISLLQLKMFINQSQSIPFRGHVYLTGECNYGGRVTDDKD 3997
            |.|..|..|||.||:..|.||..||.|....|..::..:..:|:....||.||..|||.:|||.|
Human  4089 ACVAGRLRFGPQGWSRSYPFNPGDLTICASVLYNYLEANSKVPWEDLRYLFGEIMYGGHITDDWD 4153

  Fly  3998 RRLILSLLNMIYNPNTIEEDNYALSQSGTYRVPLSPTRLNSIEYVSSFPLSPHPEVYGLHENADI 4062
            |:|....|....||:..|::   |..:..:..|.........:|:........|.:||||.||:|
Human  4154 RKLCRVYLEEFMNPSLTEDE---LMLAPGFAAPPYLDYAGYHQYIEEMLPPESPALYGLHPNAEI 4215

  Fly  4063 NRNVKETNALISGVLLTQTDLMASVKASSSGGAKEDPAIAICKQVLKQLPEEFNIDEV----SKT 4123
            ......:|.|...:|..|.  ..::.....|.:.|:....:...:|::||||||:.|:    |..
Human  4216 EFLTVTSNTLFRTLLEMQP--RNALSGDELGQSTEEKVKNVLDDILEKLPEEFNMAEIMQKNSNR 4278

  Fly  4124 YPVIYTNSMNTVLRQELIRFNRLLSYIRKSLVNVGKAVVGQIAMIPELERTHASMVIGKLPADWL 4188
            .|.:      .|..||..|.|.|:..||.||..:..::.|::|:.|.:|....::....:|..|.
Human  4279 SPYV------LVCFQECERMNILIREIRISLEQLDLSLKGELALSPAVEAQQFALSYDTVPDTWS 4337

  Fly  4189 KKSYPSLKPLGSYVSDLLARLAFFQEWI-DNGEPMVYWISGFYFTQSFITGVLQNYSRKNRFQID 4252
            |.:|||...|..:.:|||.|......|. |...|.|.|:|||:..|||:|.::|..:|||.:.:|
Human  4338 KLAYPSTYGLAQWFNDLLLRCRELDTWTQDLTLPAVVWLSGFFNPQSFLTAIMQTMARKNEWPLD 4402

  Fly  4253 MILIEFAVTKFEVQVPG-TPDIGAYIRGIFIEGARWNRKTKEVDESFSKVLFDTLPVIYLR--PV 4314
            ...:...|||...:..| .|..|||:.|:|:|||||:.:...:.|:..|.|...:|||:.:  ||
Human  4403 KTRLTADVTKKTKEDYGHPPREGAYLHGLFMEGARWDTQAGTIVEARLKELACPMPVIFAKATPV 4467

  Fly  4315 LKALEDLPRSTAGGEPETIYDCPVYKTSERRGVLSTTGHSTNFVMYLQLRCSRKPMHWINRGTAC 4379
            .:.           |.:..|:||||:|..|         ..:::...:|:...|...|:..|.|.
Human  4468 DRQ-----------ETKQTYECPVYRTKLR---------GPSYIWTFRLKSEEKTAKWVLAGVAL 4512

  Fly  4380 LCQ 4382
            |.:
Human  4513 LLE 4515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dnah3	NP_647937.2	DHC_N2	1086..1489	CDD:285579	111/435 (26%)
		P-loop_NTPase	1620..1847	CDD:304359	133/226 (59%)
		P-loop_NTPase	1934..2079	CDD:304359	57/157 (36%)
		P-loop_NTPase	2264..2522	CDD:304359	76/258 (29%)
		P-loop_NTPase	2613..2916	CDD:304359	98/303 (32%)
		MT	2929..3272	CDD:289543	108/347 (31%)
		AAA_9	3304..3519	CDD:289547	93/219 (42%)
		Dynein_heavy	3659..4373	CDD:281078	219/735 (30%)
DNAH11	NP_001264044.1	Stem. /evidence=ECO:0000250	1..1854		390/1904 (20%)
		DHC_N1	239..812	CDD:285571	119/677 (18%)
		DHC_N2	1319..1722	CDD:285579	112/436 (26%)
		P-loop_NTPase	1855..2084	CDD:304359	134/228 (59%)
		AAA 1. /evidence=ECO:0000250	1855..2076		131/220 (60%)
		AAA 2. /evidence=ECO:0000250	2136..2366		80/242 (33%)
		P-loop_NTPase	2169..2313	CDD:304359	56/156 (36%)
		P-loop_NTPase	2471..2741	CDD:304359	77/272 (28%)
		AAA 3. /evidence=ECO:0000250	2472..2719		69/249 (28%)
		AAA 4. /evidence=ECO:0000250	2817..3066		90/286 (31%)
		P-loop_NTPase	2818..3085	CDD:304359	98/304 (32%)
		Stalk. /evidence=ECO:0000250	3072..3403		102/341 (30%)
		MT	3097..3441	CDD:289543	109/354 (31%)
		AAA 5. /evidence=ECO:0000250	3459..3686		98/234 (42%)
		AAA_9	3468..3680	CDD:289547	93/219 (42%)
		Dynein_heavy	3820..4506	CDD:281078	219/735 (30%)
		AAA 6. /evidence=ECO:0000250	3896..4122		83/241 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5245
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100025
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.710