DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dnah3 and DNAH7

DIOPT Version :9

Sequence 1:	NP_647937.2	Gene:	Dnah3 / 38586	FlyBaseID:	FBgn0035581	Length:	4385	Species:	Drosophila melanogaster
Sequence 2:	NP_061720.2	Gene:	DNAH7 / 56171	HGNCID:	18661	Length:	4024	Species:	Homo sapiens

Alignment Length:	4033	Identity:	1780/4033 - (44%)
Similarity:	2462/4033 - (61%)	Gaps:	295/4033 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   446 VRQDLAILI--IVCLID-LQEDFRHYVKRSFLNYLLSSNME----RRRLQLEREPPEFPILTISP 503
            |.|.|.:..  ||.|.| ::||:...|::|.::::|....|    ::..:|.....|..||
Human   192 VPQHLKVFTDSIVTLSDEMREDYLLSVRKSIVDFVLKDPREKGDDKKTDELPAHRAEMEIL---- 252

  Fly   504 PVSWRSNLLRGKARIGEVLMTTHPTVQALNRLWHDLYEDLVVVDLGQLLLAQRPLDADTVQVFIE 568
            |..||.:.|...:.|.:.|...:||:.|:..|||..::.|.:||:.:....|..|:..:.|..|.
Human   253 PKPWRKSFLAASSYIRDHLNAMNPTMLAVLDLWHTNFKKLRLVDIKEFHNCQDALELSSFQNIIM 317

  Fly   569 KSCADVRDLLLNDWLPRCADLMNEMRGTWKDLVPMSGKYGGRAAMLFRCIHSAMSRHLNSLISKS 633
            :.....::.||..|.|...::.  .:|..|..:| :|....:....|.|..:.|:..|..|
Human   318 RHMDSAKETLLKMWFPEVQNIY--YQGNKKKQLP-TGDSSAKLESFFNCAAALMTLQLQDL---- 375

  Fly   634 INYLFKVLCAFKGGNRIEKYSMFDAKLKRIPLMTLIASVVGAHFDHEPINMGPGVRPASNIYVYD 698
                                             ||::                 ::..:::....
Human   376 ---------------------------------TLVS-----------------MQDFTDLIAQP 390

  Fly   699 EDDADPFQQPQVNQFVENVPDIDDVAQFELDHSNKLYIYPYMQELPRIFTEHFKSILAVGYEIPR 763
            .|....|:.|   .|:..:...:|..:||.:.|:.:.|:..:.::         .|.||.: :||
Human   391 PDSVRAFEHP---GFIMRLILDNDTIKFEPELSDYIDIFLNVYDV---------MIKAVSF-VPR 442

  Fly   764 LEFVM-----SGGEPETKG--FLHFIDEDHVDFLELCEKVEQIVKVNWQGVHVYLKPVYKYYFGL 821
            :|..:     |..:|.|..  .|:.|.:.|.      ||:::::.........:|:...||.|.:
Human   443 VETKLYSKWESKSKPTTLKPIILNEIVDAHK------EKIKEVIMKESVAPTEHLRLYDKYDFLI 501

  Fly   822 FQKLILPMVQKVWTENN-----LPELGAVQELLKKLQAVSDTTYYLRDFIPLNLFMLDNRHVKLS 881
            .:|.... |.....||:     :.|:...|:|::::|..|..|      |.|.:|.:   |.:..
Human   502 TRKAERD-VDNFLAENHSYEKIIDEICKYQKLIEEIQYTSIKT------IRLGMFEM---HCEEL 556

  Fly   882 LRMYVREIYDFIIDFYKALNWNE----NRAICEELEEMSMKAGERPEETPEVVALQNYINDCREM 942
            :|..|:.. |.|.....|..:.:    |..:|:|.|.::.||...|..|.|::.::.||......
Human   557 IRALVKRA-DIICGKLLAKMFRDHQEVNTRLCDEFERIAEKALSTPPNTAELMEMKAYIQKVEVT 620

  Fly   943 RIFAIKDEIKNVLKRVVFLLTHTYLSSDELHLNSRTFILPGELEEVLDLSAARLAVVRDNLE--- 1004
            .:..::..:.:....:.||:.:...|..::.||:..|...|.:.|:.:   ....::::.:|
Human   621 DMIELEQRLVDSKNCLAFLIEYVNFSPADMRLNNSVFQWYGRMGEIFE---EHRKIIKEKIEQYQ 682

  Fly  1005 --LALRERRMEFEKLLAQEKRTMDGFRIREIRDVLT-LEELKERVDTVDLLFTTIENLSREAKAI 1066
              |.||..|. .|:|.:..|::.:.:...:::||.. |::.:.....:||....||.       .
Human   683 EGLKLRCERF-VEELESYAKQSEEFYSFGDLQDVQRYLKKAQILNGKLDLAADKIEQ-------F 739

  Fly  1067 NTEETLLQIDVSAFPLLAEIIEKMEPIEKLWKTSYEFEKDYLIWMFERFECLNADGVREQVENMH 1131
            |.||.......|.:|...:|.:.:.|..:|::|:.||..:|..|....:..:|.|.|...:.|..
Human   740 NAEEEAFGWLPSVYPQRKKIQDGLNPYLRLYETAVEFSSNYRAWTEGPYHKVNPDQVEADIGNYW 804

  Fly  1132 KIMYKLSRQLAYNPVAKRAAEQMRMKIEKFRVYLPVLDSICRHGLEKRHWDQISKILGRKVNPKL 1196
            :.:|||.:....:|.|....:::|.|:|.|:.::|::..||..||..|||:.:|.|:|..:.|..
Human   805 RGLYKLEKTFHDSPYALAMTKKVRSKVEDFKQHIPLIQVICNPGLRPRHWEAMSAIVGYPLQPSD 869

  Fly  1197 FPTLKDMIDVDIMSILPQLEEIANAAGKEYDLNNGLRIMQADWRDVMFEVLQYRDSDTHILASLD 1261
            ..|:...:|:::...:.:.|.|:.||.|||.|...:..|..:|..|.|.:..||::.|.||||:|
Human   870 DSTVSSFLDMNLEPYIDRFEGISEAASKEYSLEKAMEKMITEWDAVEFVIHSYRETGTFILASVD 934

  Fly  1262 DIQTLLDDHIMRTQAMKRSPFITALGSKADDWEARLLLIQNIIDAWTQVQITWMYLEPIFSSEDI 1326
            :||.||||||::||.|:.||||.....:..:||.:|||:|.|:|.|.:||.||:||||||||.||
Human   935 EIQMLLDDHIIKTQTMRGSPFIKPYEKQMREWEGKLLLLQEILDEWLKVQATWLYLEPIFSSPDI 999

  Fly  1327 MRQMPLEGRNFKAVDKLWRKIMKHTLKDRHVMAATEYPEMLEVFTKAIEDLETVTKGLNTYLEQK 1391
            |.|||.|||.|.||||.||.||:..::|:||:.......|||...|:.|.||.:.||||.|||:|
Human  1000 MSQMPEEGRRFTAVDKTWRDIMRSVMQDKHVLTVVTIDRMLERLKKSNELLELILKGLNEYLEKK 1064

  Fly  1392 RLFFARFFFLSNDELLEILSETKDPMRVQPHLRKCFEGIGSLTFDDNMEIVEMVSDEEERVALVR 1456
            ||||.||||||||||||||||||||.||||||:||||||..:.|.:.::|..|.|.|.|.|.|:.
Human  1065 RLFFPRFFFLSNDELLEILSETKDPTRVQPHLKKCFEGIAKVEFTETLDITHMKSSEGEVVELIE 1129

  Fly  1457 KINPQLANGLVEMWLKEVEMVMLDSVKEQMREAWEDYAMVERISWVVSWPGQVVQGISCMAWTYE 1521
            .|:...|.|.||.||.|:|.||::|:.:...:|...|...|||:||..||||.|..:|.:.||.|
Human  1130 IISTAKARGQVEKWLVELERVMINSIHKVTGDATFAYTKYERINWVRDWPGQTVLCVSQIFWTKE 1194

  Fly  1522 VEEAIE--TKELPAYLEKSNLQIADLVQLVRTDLQAGVRIAVEALIVLDVHDRDVVKYLTDCRIT 1584
            |:.||.  .|.|..||:..|.||.|:|.|||..|....|:.:.||:|||||.|||:..|....|:
Human  1195 VQTAIPMGIKALEQYLKTCNRQIDDIVTLVRGKLSMQNRVTLGALVVLDVHARDVLSSLVKKNIS 1259

  Fly  1585 NIQDFDWISQLRYYWKVNEKNEDWVCVSMVVTDVEYGMEYLGNLPRLVVTPLTDRCYRTLMGALK 1649
            :..||:|:|||||||:.|...     ..|:...:.||.|||||.||||:|||||||||||.|||.
Human  1260 DDSDFEWLSQLRYYWQENHLE-----TKMINAGLRYGYEYLGNSPRLVITPLTDRCYRTLFGALH 1319

  Fly  1650 LCLGGAPEGPAGTGKTETCKDLAKAVAKKCVVFNCSDGLDYKALGKFFKGLAQSGAWACFDEFNR 1714
            |.||||||||||||||||.|||||||||:||||||||||||.|||||||||...|||||||||||
Human  1320 LHLGGAPEGPAGTGKTETTKDLAKAVAKQCVVFNCSDGLDYLALGKFFKGLLSCGAWACFDEFNR 1384

  Fly  1715 IELEVLSVVAQQILTIQRAIGRKVVKFFFEDTMLKLDPTCSIFITMNPGYAGRTELPDNLKVLFR 1779
            |:||||||||||||||||.|........||.|.|||||||::|||||||||||:|||||||.|||
Human  1385 IDLEVLSVVAQQILTIQRGINAGADILMFEGTELKLDPTCAVFITMNPGYAGRSELPDNLKALFR 1449

  Fly  1780 TVAMMVPDYAMIGEITLYSNGFDMARNLSQKIVQAYKLCSEQLSSQSHYDYGMRAVKSVLLASAS 1844
            ||||||||||||.||.|||.||..||.||.|||..|:|||||||||.|||||||||||||.|:.:
Human  1450 TVAMMVPDYAMIAEIVLYSCGFVTARPLSVKIVATYRLCSEQLSSQHHYDYGMRAVKSVLTAAGN 1514

  Fly  1845 LRRLYVDLPEPEIVLRAIVDVNLPKFLEQDISLFIGIYMDLFPGVELPMPQRGDILKWLHINLAD 1909
            |:..|.:..|..::||:|:||||||||..|:.||.||..||||||:||.|...|:|..:..|.|.
Human  1515 LKLKYPNENEEILLLRSIIDVNLPKFLSHDLPLFEGITSDLFPGVKLPKPDYNDLLAAIKDNCAS 1579

  Fly  1910 RNLQATPWYLEKILQIYEMLLVRHGLMIVGGSMGGKTTAYQVLAQTLRNVSTDEEATLKEFPVTF 1974
            .|||.|.::.|||||:|||::||||.||||...||||:||:|||..|.::.  |:..::|..|..
Human  1580 MNLQMTAFFSEKILQVYEMMIVRHGFMIVGEPFGGKTSAYRVLAGALNDIC--EKGLMEENKVQI 1642

  Fly  1975 RIINPKAITMGQLYGRFDPVSHEWYDGVLAKTFREQVQGPKGERAWVMFDGPVDAVWIENLNTVL 2039
            .::|||::|||||||:||.|||||.|||||.:||........:|.|::||||||||||||:||||
Human  1643 TVLNPKSVTMGQLYGQFDSVSHEWSDGVLAVSFRAFASSVTPDRKWLIFDGPVDAVWIENMNTVL 1707

  Fly  2040 DDNKKLCLMSGEIMQMTKLMNMMFEPADLEQASPATVSRCGMIYMEPSQLGWRALHKSFINVLVN 2104
            |||||||||||||:||:..||::|||.|||.||||||||||||||||..||||.|..|::|:|..
Human  1708 DDNKKLCLMSGEIIQMSPQMNLIFEPMDLEVASPATVSRCGMIYMEPHMLGWRPLMLSWVNLLPA 1772

  Fly  2105 KVGL--GDIYMTLFEDMTEWLVPAALEFLPQCKQMLELSPIYQYQTFSRFFLHFLE--------- 2158
            .|.:  .:..|.||:.|    ||.::||:.  |...||||... ....|..::.::
Human  1773 SVSVIQKEFIMGLFDRM----VPVSVEFIR--KHTKELSPTSD-TNLVRSLMNLIDCFMDDFADE 1830

  Fly  2159 -KHKQFNQ----AWFQQMFLFCFAWAYCSALTGQGQKTFDALLRKVIYGSNENFPKPKYFSLNRG 2218
             |.|:.|.    :..:.:|||...|:..::.|...:..|:.:||:::.....:..: ..|.|..|
Human  1831 VKLKERNDRETYSLLEGIFLFSLIWSVGASCTDDDRLKFNKILRELMESPISDRTR-NTFKLQSG 1894

  Fly  2219 Q----------MFPEKLLFLDYRF--DEAENWWTWQKSDDSASTTSNFPENAQISELIVPTKETG 2271
            .          .||||....||:|  :....|..|.|....|..   .|::...:|:||||.:|.
Human  1895 TEQTSSKALTVPFPEKGTIYDYQFVTEGIGKWEPWIKKLKEAPP---IPKDVMFNEIIVPTLDTI 1956

  Fly  2272 YISYWQEFCISKSYAMLVVGPTGTGKSAIITSNLLAMPKFANLVN-------VINFSARTSAQMV 2329
            ..|...|...:.....:.|||||||||..||:.||      |.:|       :|||||:|:|...
Human  1957 RYSALMELLTTHQKPSIFVGPTGTGKSVYITNFLL------NQLNKEIYKPLLINFSAQTTAAQT 2015

  Fly  2330 QDTIMSKLDRRRKGVFGPSLGKKCTVFCDDVAMPSKDTYGSQAPLELLRTWLDHGYWSDLVDTTK 2394
            |:.:|||||:||||||||.|||:..||.|||.||:::.||:|.|:||||.||||..|.||.|.:.
Human  2016 QNIVMSKLDKRRKGVFGPPLGKRMVVFVDDVNMPAREVYGAQPPIELLRQWLDHWNWYDLKDCSM 2080

  Fly  2395 IELVDMTLMCAMGTLGGS-NFIFPRLYRHMFVVAVDSFEDSTIVRIFTTIGDWHFSKGY--PEKV 2456
            |:|||:.:|||||..||. |.:.||..||..::.::.|.|.::..||:.|..||....|  |::.
Human  2081 IKLVDIQIMCAMGPPGGGRNPVTPRYMRHFNIITINEFSDKSMYTIFSRILTWHLEICYKFPDEF 2145

  Fly  2457 ALLSRGLSEAMVSVYRDAIRSFLPTPAKSHYSFSLRDITRVFQGIVMVPPKRMPDPEKLGRLWAH 2521
            ..|:..:....:::|::|:::.|||||||||.|:|||.:||.||:.:..|:.....|.:.|||.|
Human  2146 LDLTTQIVNGTMTLYKEAMKNLLPTPAKSHYLFNLRDFSRVIQGVCLSRPETTETTEVIKRLWVH 2210

  Fly  2522 ETYRVFYDRLVDQQDRDRLLVMAVDACKSNLRFPLEQAFGERIEPGEKLTDN-------DLRNLF 2579
            |..||:||||:|..||..|:....:..::.:.....:.| :|::     .||       |||:|.
Human  2211 EVLRVYYDRLLDNTDRSWLINYIQEILRNYMYEDFHELF-QRLD-----FDNDGMVEADDLRSLM 2269

  Fly  2580 YGNYMEPDAEPKFYDEGDTYEKLEKLMKYYLREYNSFSSTPMDLVMFRFAIEHVSRVSRVLQMPR 2644
            :.::.:|..|...|.|....:.|..:::.:|.|||:.|..||:||:|||||||:||:||:|:.||
Human  2270 FCDFHDPKREDTNYREIADVDNLRMIVEIHLEEYNNISKKPMNLVLFRFAIEHISRISRILKQPR 2334

  Fly  2645 GNILMVGMGGSGRRSSARLAAYIADCRLMTVQVSKSYTITDWRDDLKKILMSASFNLNHTVFLFS 2709
            .:.|:||:|||||:|..||||::||..:..|::||.|..|:|.:|||.||...:......||||:
Human  2335 SHALLVGVGGSGRQSVTRLAAHMADYSVFQVEISKGYDTTEWHEDLKVILRKCAEGEMQGVFLFT 2399

  Fly  2710 DAQATDEGYVEDINGILNTGDLPNLYQLEDKATIMENMANVAKQLGKI--LDTLPSEVYAYYIDR 2772
            |.|..:|.::||::.:||.|::|||:.|::|..|.:.|..:.:|..|.  .|..|..::..:||.
Human  2400 DTQIKEESFLEDVSNLLNAGEIPNLFALDEKQEICDKMRQLDRQRDKTKQTDGSPIALFNMFIDH 2464

  Fly  2773 IREQLHIALAFSPIGDSFKERIRVYPSLINCCTIDWYMPWPEEALSRVGVYFVSSMNLNRPHGEE 2837
            .|.|||:.||.|||||:|:.|:|.:|:|:|||||||:..|||:||..|...|:..:.::
Human  2465 CRSQLHVVLAMSPIGDAFRNRLRKFPALVNCCTIDWFQSWPEDALQAVASRFLEEIEMS------ 2523

  Fly  2838 TQEPVQSKDAADPDEEEVRRETVGVEREQTQLEADLVDCVMYFHQSVVDASEKCYLELNRRNYVT 2902
                           ||:|              ...:|....||.|.:|.|:..::||.|.||||
Human  2524 ---------------EEIR--------------DGCIDMCKSFHTSTIDLSKSFFVELQRYNYVT 2559

  Fly  2903 PSAYLELLKAFRTFYTRKLDEITRLRDRYTTGLEKLDFAAGQVGEMQTNLYDLQPKLKVLSEETD 2967
            |::||||:..|:....:|..|:.:::.||..||||||.|:.||..||..|..|.|:|||.|:|.|
Human  2560 PTSYLELISTFKLLLEKKRSEVMKMKKRYEVGLEKLDSASSQVATMQMELEALHPQLKVASKEVD 2624

  Fly  2968 RIMVNIERETAEAEKKKEVVGADEAAANEAAAAAQAIKDDCETDLAEAIPAMEAALEALNTLKPA 3032
            .:|:.||:|:.|..|.:::|.|||..|||.|.|::||||:|:.|||.|:|.:|:||.||:||...
Human  2625 EMMIMIEKESVEVAKTEKIVKADETIANEQAMASKAIKDECDADLAGALPILESALAALDTLTAQ 2689

  Fly  3033 DIFIVKSMKNPPYGVKLTMEAVCVIRGIKPDRKPDP--SGHMVEDYWGPSMRMLSDMKFLDSLKT 3095
            ||.:|||||:||.||||.|||:|:::|||.|:.|||  ||..:||:|||:.|:|.||:||.||..
Human  2690 DITVVKSMKSPPAGVKLVMEAICILKGIKADKIPDPTGSGKKIEDFWGPAKRLLGDMRFLQSLHE 2754

  Fly  3096 FDKDNIPPPIIKRIREKYIADRDFVPEKIKAASMACEGICRWVRAMDVYDKVARIVMPKKAALAE 3160
            :|||||||..:..||:.||.:.|||||||:.||.|.||:|:||.|||.|||||:||.|||..||.
Human  2755 YDKDNIPPAYMNIIRKNYIPNPDFVPEKIRNASTAAEGLCKWVIAMDSYDKVAKIVAPKKIKLAA 2819

  Fly  3161 AEGELSQQMEKLNAKRAELQVILDKLQKLNDFFAEKSREKKRLEDEIDNCEKKLNRAEKLLGGLG 3225
            |||||...|:.|..|:|.|:.:.|||.:|.|......::|..||:::|.|.|||.|||:|:||||
Human  2820 AEGELKIAMDGLRKKQAALKEVQDKLARLQDTLELNKQKKADLENQVDLCSKKLERAEQLIGGLG 2884

  Fly  3226 GEKTRWSEAAKNLHESISNIVGDVLLAGGCTAYLGYFTTEYRVNILDDWNALCKRKHIPSSETFS 3290
            |||||||..|..|.:...|:.||:|::.|..||||.||:.||.|...:|..|||.:.||.|:..|
Human  2885 GEKTRWSHTALELGQLYINLTGDILISSGVVAYLGAFTSTYRQNQTKEWTTLCKGRDIPCSDDCS 2949

  Fly  3291 LATTLGHPMTIRAWSLAGLPADNFSVENGIIVTNSSRYSLLIDPQVQANKWIKNMEKNNNLKVIK 3355
            |..|||..:|||.|::||||:|:||::||||:.|:.|:.|:||||.|||||||||||.|:|.|||
Human  2950 LMGTLGEAVTIRTWNIAGLPSDSFSIDNGIIIMNARRWPLMIDPQSQANKWIKNMEKANSLYVIK 3014

  Fly  3356 QSDANYMQVLELAITFGQPVLIENVGEKLDSNLTPILEKNVIKHKGGLFIKSGDQMIEYNPNFRL 3420
            .|:.:|::.||..|.||.|||:|||||:||..|.|:|.|...|..|...|:.||..|||.|:||.
Human  3015 LSEPDYVRTLENCIQFGTPVLLENVGEELDPILEPLLLKQTFKQGGSTCIRLGDSTIEYAPDFRF 3079

  Fly  3421 YITTCLRNPRYPPEVMVMVTVLNFMITEQGLREQLLAIVVAHERPDLQEKKEQLIIESARNRDAL 3485
            ||||.||||.|.||..|.||:||||||.:|:::|||.||||.|||||:|:|:.||::.|.|:..|
Human  3080 YITTKLRNPHYLPETSVKVTLLNFMITPEGMQDQLLGIVVAQERPDLEEEKQALILQGAENKRQL 3144

  Fly  3486 YTIESKILEVLSTSEGNVLEDENAINILSSSKILSEDIQEKQVIAVATEIEIDAARQQYIPVSKH 3550
            ..||.|||||||:||||:||||.||.||||||.|:.:|.:||.:|..||.:||..|..|.|::.|
Human  3145 KEIEDKILEVLSSSEGNILEDETAIKILSSSKALANEISQKQEVAEETEKKIDTTRMGYRPIAIH 3209

  Fly  3551 SAILFFCISELANVDPMYQYSLSWFLNLFVNTILKAPKSDQLSERLKNLNDYFTKSIYTNVCRSL 3615
            |:||||.:::|||::|||||||:||:|||:.:|..:.||:.|::||:.|.|:||.|:|.||||||
Human  3210 SSILFFSLADLANIEPMYQYSLTWFINLFILSIENSEKSEILAKRLQILKDHFTYSLYVNVCRSL 3274

  Fly  3616 FEKDKLVISLVMCLGILVSQGRVEKAALLFFLTGGIGYKTIPPNP---LGAWLPDKSWASVCKAA 3677
            ||||||:.|..:.:.:|:.:..:.||...|.||||||.    .||   |..|||.|||..:|:..
Human  3275 FEKDKLLFSFCLTINLLLHERAINKAEWRFLLTGGIGL----DNPYANLCTWLPQKSWDEICRLD 3335

  Fly  3678 DLEGLKNLPQMMETYSDEWHNFYDASNPDQLQLPAP-HNTVNDMYFLIVIKSLRPDKLVPAVRAF 3741
            ||...|.:.:......|.|...||:..|.....|.. .:..|:...:::|:.|||||::|.::.|
Human  3336 DLPAFKTIRREFMRLKDGWKKVYDSLEPHHEVFPEEWEDKANEFQRMLIIRCLRPDKVIPMLQEF 3400

  Fly  3742 ITRNLDRSFVEPPPFDLAASFADSSPKIPLVFLLSAGSDPMASLFMFAKQRNMY--DKLKTISLG 3804
            |...|.|:|:||||||||.:|.||:...||:|:||.|:||||:|..||..:. |  .||.::|||
Human  3401 IINRLGRAFIEPPPFDLAKAFGDSNCCAPLIFVLSPGADPMAALLKFADDQG-YGGSKLSSLSLG 3464

  Fly  3805 QGQGPRAEKMIMEAARHGQWVVLQNCHVAISWMGDLERICNDTTLTDGANH-DYRLWCTSYPSAV 3868
            |||||.|.||:.:|.:.|.||||||||:|.|||..||::|.:  |:..:.| |:|:|.|||||..
Human  3465 QGQGPIAMKMLEKAVKEGTWVVLQNCHLATSWMPTLEKVCEE--LSPESTHPDFRMWLTSYPSPN 3527

  Fly  3869 FPVSVLQNSVKMTNEPPKGLRANMHRSFTSDPLMRDKFFTNAFLFSDSANKC-----WLRGVFAL 3928
            ||||||||.||||||.|||||||:.||:..||:...:||          ..|     :.:.::.|
Human  3528 FPVSVLQNGVKMTNEAPKGLRANIIRSYLMDPISDPEFF----------GSCKKPEEFKKLLYGL 3582

  Fly  3929 VFFHAVVQERREFGPLGWNIPYEFNESDLKISLLQLKMFINQSQSIPFRGHVYLTGECNYGGRVT 3993
            .||||:|||||:||||||||||||||:||:||:.||.||:||.:.:|:....|:|||||||||||
Human  3583 CFFHALVQERRKFGPLGWNIPYEFNETDLRISVQQLHMFLNQYEELPYEALRYMTGECNYGGRVT 3647

  Fly  3994 DDKDRRLILSLLNMIYNPNTIEEDNYALSQSGTYRVPLSPTRLNSIEYVSSFPLSPHPEVYGLHE 4058
            ||.|||.:.|:||..:||..:|..:|....||.|.||.|....:.|||..:.||:|.||::|::.
Human  3648 DDWDRRTLRSILNKFFNPELVENSDYKFDSSGIYFVPPSGDHKSYIEYTKTLPLTPAPEIFGMNA 3712

  Fly  4059 NADINRNVKETNALISGVLLTQTDLMASVKASSSGGAKEDPAIA--ICKQVLKQLPEEFNIDEVS 4121
            ||||.::..||..|...:||||:       .|:..|||....:.  :...:|.:||..|:|:...
Human  3713 NADITKDQSETQLLFDNILLTQS-------RSAGAGAKSSDEVVNEVASDILGKLPNNFDIEAAM 3770

  Fly  4122 KTYPVIYTNSMNTVLRQELIRFNRLLSYIRKSLVNVGKAVVGQIAMIPELERTHASMVIGKLPAD 4186
            :.||..||.||||||.||:.|||:||..||.|.||:.||:.|...|..:||...:|::..|:|..
Human  3771 RRYPTTYTQSMNTVLVQEMGRFNKLLKTIRDSCVNIQKAIKGLAVMSTDLEEVVSSILNVKIPEM 3835

  Fly  4187 WLKKSYPSLKPLGSYVSDLLARLAFFQEWIDNGEPMVYWISGFYFTQSFITGVLQNYSRKNRFQI 4251
            |:.|||||||||||||:|.||||.|.|:|.:.|.|.|:|:|||:|||:|:||..|||:||....|
Human  3836 WMGKSYPSLKPLGSYVNDFLARLKFLQQWYEVGPPPVFWLSGFFFTQAFLTGAQQNYARKYTIPI 3900

  Fly  4252 DMILIEFAVTKFEVQVPGTPDIGAYIRGIFIEGARWNRKTKEVDESFSKVLFDTLPVIYLRPVLK 4316
            |::..::.|.: :.:....|:.|.:|.|:|::||.||||.|::.||..|:|:||:||::|:|..:
Human  3901 DLLGFDYEVME-DKEYKHPPEDGVFIHGLFLDGASWNRKIKKLAESHPKILYDTVPVMWLKPCKR 3964

  Fly  4317 ALEDLPRSTAGGEPETIYDCPVYKTSERRGVLSTTGHSTNFVMYLQLRCSRKPMHWINRGTACLC 4381
            |  |:|:..:       |..|:||||||||||||||||||||:.:.|...:...|||.||.|.||
Human  3965 A--DIPKRPS-------YVAPLYKTSERRGVLSTTGHSTNFVIAMTLPSDQPKEHWIGRGVALLC 4020

  Fly  4382 QLD 4384
            ||:
Human  4021 QLN 4023

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dnah3	NP_647937.2	DHC_N2	1086..1489	CDD:285579	183/402 (46%)
		P-loop_NTPase	1620..1847	CDD:304359	183/226 (81%)
		P-loop_NTPase	1934..2079	CDD:304359	90/144 (63%)
		P-loop_NTPase	2264..2522	CDD:304359	119/267 (45%)
		P-loop_NTPase	2613..2916	CDD:304359	124/304 (41%)
		MT	2929..3272	CDD:289543	188/344 (55%)
		AAA_9	3304..3519	CDD:289547	132/214 (62%)
		Dynein_heavy	3659..4373	CDD:281078	342/727 (47%)
DNAH7	NP_061720.2	Stem. /evidence=ECO:0000250	1..1289		376/1203 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	49..121
		DHC_N2	763..1162	CDD:285579	182/398 (46%)
		P-loop_NTPase	1290..1520	CDD:304359	183/229 (80%)
		AAA 1. /evidence=ECO:0000250	1290..1511		181/220 (82%)
		AAA 2. /evidence=ECO:0000250	1571..1802		134/238 (56%)
		P-loop_NTPase	1604..1747	CDD:304359	90/144 (63%)
		AAA 3. /evidence=ECO:0000250	1938..2189		114/259 (44%)
		P-loop_NTPase	1942..2211	CDD:304359	120/274 (44%)
		AAA 4. /evidence=ECO:0000250	2302..2555		114/287 (40%)
		P-loop_NTPase	2303..2574	CDD:304359	124/305 (41%)
		Stalk. /evidence=ECO:0000250	2572..2873		157/300 (52%)
		MT	2586..2933	CDD:289543	188/346 (54%)
		AAA 5. /evidence=ECO:0000250	2954..3184		139/229 (61%)
		AAA_9	2962..3178	CDD:289547	132/215 (61%)
		Dynein_heavy	3322..4012	CDD:281078	339/719 (47%)
		AAA 6. /evidence=ECO:0000250	3397..3620		128/235 (54%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5245
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	1	Normalized mean entropy	S4613
OMA	1	1.010	-	-		QHG56321
OrthoDB	1	1.010	-	-		D1872at33208
OrthoFinder	1	1.000	-	-		FOG0000321
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100025
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1547
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.680