DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dnah3 and DYNC1H1

DIOPT Version :9

Sequence 1:	NP_647937.2	Gene:	Dnah3 / 38586	FlyBaseID:	FBgn0035581	Length:	4385	Species:	Drosophila melanogaster
Sequence 2:	NP_001367.2	Gene:	DYNC1H1 / 1778	HGNCID:	2961	Length:	4646	Species:	Homo sapiens

Alignment Length:	4891	Identity:	1195/4891 - (24%)
Similarity:	2100/4891 - (42%)	Gaps:	938/4891 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQKKVAPERRPYCDPRLQDDKLRRKRTLHLPRVS------------QAQKKGEKRQLNDC----- 48
            ::||:|         .|:...|..::.:.:|.:|            |..::|||.::.|.
Human   182 VEKKIA---------ELEMGLLHLQQNIEIPEISLPIHPMITNVAKQCYERGEKPKVTDFGDKVE 237

  Fly    49 --PFYN-LTYGFD----------QLPLDPVKEFLQEKISH--------------------MQTDK 80
              .|.| |..|.:          :|..||......::||.                    :.|..
Human   238 DPTFLNQLQSGVNRWIREIQKVTKLDRDPASGTALQEISFWLNLERALYRIQEKRESPEVLLTLD 302

  Fly    81 IVGHCNREFDFH---RYDLD-NVKDEYDECDDDS--LQELQLEDIIMPEQFEMLRDAK----DHL 135
            |:.|..|   ||   .:|.| .:|...:..:|.:  :::..|.|::...:.:.:|.|.    .||
Human   303 ILKHGKR---FHATVSFDTDTGLKQALETVNDYNPLMKDFPLNDLLSATELDKIRQALVAIFTHL 364

  Fly   136 YNFDSTACNQFPWIDKWMTGVRPSEQEIYEMTSHLLEIYCNRR-VRIFYP-------GCGTSSSL 192
            ....:|   ::| |.:   .:|..|....:::|.||::...|: :.:.|.       .|......
Human   365 RKIRNT---KYP-IQR---ALRLVEAISRDLSSQLLKVLGTRKLMHVAYEEFEKVMVACFEVFQT 422

  Fly   193 WTNQLRRQHGSPSELIGAYR----------TPSARHM--RVNNMRGPPKKEKFTAGDHYAFRTPQ 245
            |.::..:......:::...|          .|:.|.:  |::.||      ||.       |..:
Human   423 WDDEYEKLQVLLRDIVKRKREENLKMVWRINPAHRKLQARLDQMR------KFR-------RQHE 474

  Fly   246 ECRNELMRVGKIIDELIEPVLKAAEHKIGHGLTKYPDPPSCK---------------------DN 289
            :.|..::||      |...|...|:...|    :.|:|...|                     :|
Human   475 QLRAVIVRV------LRPQVTAVAQQNQG----EVPEPQDMKVAEVLFDAADANAIEEVNLAYEN 529

  Fly   290 TNRILRSAGILVGKKKNCYVGKCRIHRKDFATNEEFLRCLKRMEATHFPYMQPLQPVDPDDQKIK 354
            ...:   .|:.|.|:                ..|.:...:||       |.:.:..|:     .:
Human   530 VKEV---DGLDVSKE----------------GTEAWEAAMKR-------YDERIDRVE-----TR 563

  Fly   355 MLAKYRVELA---RAEKLFTLKIQKRYQCLLKSMSI-VQLATYPSHLIRKA----------FRRI 405
            :.|:.|.:|.   .|.::|  :|..|:..|.....| ..:..|.:.||::.          |:..
Human   564 ITARLRDQLGTAKNANEMF--RIFSRFNALFVRPHIRGAIREYQTQLIQRVKDDIESLHDKFKVQ 626

  Fly   406 NPRSALLQDAYQFIVKEKRDWPKLPPEVI--------LMDYL-------------FVGDRGVRQD 449
            .|:|...:      :...||.|.:...:|        |..|:             .|..:.::||
Human   627 YPQSQACK------MSHVRDLPPVSGSIIWAKQIDRQLTAYMKRVEDVLGKGWENHVEGQKLKQD 685

  Fly   450 LAILIIVCLIDLQEDFRHYVKRSFLNYLLSSNMERRRLQLEREPPEFPILTI-SPPVSWRS-NLL 512
            .....:  .::.||.|..:.::          :::|.|.:...     |.|| |..|..|: |:|
Human   686 GDSFRM--KLNTQEIFDDWARK----------VQQRNLGVSGR-----IFTIESTRVRGRTGNVL 733

  Fly   513 RGKARIGEVLMTTHPTVQALNRLWHDLYEDLVVVD----LGQLL---------------LAQRPL 558
            :.|......::|....|:  |..|......|.:|:    ..||.               ..::..
Human   734 KLKVNFLPEIITLSKEVR--NLKWLGFRVPLAIVNKAHQANQLYPFAISLIESVRTYERTCEKVE 796

  Fly   559 DADTVQVFIEKSCADVRDLL------------LNDWLPRCADLMNEMRGTWKDLVPMSGKYGGRA 611
            :.:|:.:.:.....:|:.|:            |:.::.|.|:.:...:....||:.:..|.....
Human   797 ERNTISLLVAGLKKEVQALIAEGIALVWESYKLDPYVQRLAETVFNFQEKVDDLLIIEEKIDLEV 861

  Fly   612 AMLFRCI--HSAMSRHLNSLISKSINYLFKVLCAFKGGNRIEKYSMFDAKLKRIPLMTLIASVVG 674
            ..|..|:  |...|..||. :.|:::.|           .:..||.....:.::.:.  |..::|
Human   862 RSLETCMYDHKTFSEILNR-VQKAVDDL-----------NLHSYSNLPIWVNKLDME--IERILG 912

  Fly   675 AHFDHEPINMGPGVRPASNIYV-YDEDDAD---PFQQPQVNQFVENVPDIDDVAQFELDHSNK-L 734
                   :.:..|:|..:.:.: ..||.|:   ....|||:......|.|.:|.. ||..:|: :
Human   913 -------VRLQAGLRAWTQVLLGQAEDKAEVDMDTDAPQVSHKPGGEPKIKNVVH-ELRITNQVI 969

  Fly   735 YIYPYMQE------------------LPRIFTEHFKSILAVGYEIPRLEFVMSGGEPETKGFLHF 781
            |:.|.::|                  ||||.::.::  :.|.||:...|................
Human   970 YLNPPIEECRYKLYQEMFAWKMVVLSLPRIQSQRYQ--VGVHYELTEEEKFYRNALTRMPDGPVA 1032

  Fly   782 IDEDHVDFLELCEKVEQIVKVNWQGVHVYLKPVYKYYFGLFQKLILPMVQKVW---TENNLPELG 843
            ::|.:...:.:..:|||.||| |          .:|             |.:|   .||....||
Human  1033 LEESYSAVMGIVSEVEQYVKV-W----------LQY-------------QCLWDMQAENIYNRLG 1073

  Fly   844 -------AVQELLKKLQAVSDTTYYLRDFIP-----------LNLFMLDNRHVKLSLRMYVREIY 890
                   |:...::|.:...|.....::|.|           :|| ..|:.| |..|..:.:.:.
Human  1074 EDLNKWQALLVQIRKARGTFDNAETKKEFGPVVIDYGKVQSKVNL-KYDSWH-KEVLSKFGQMLG 1136

  Fly   891 DFIIDFYKALNWNENRAICEELEEMSMKAGERPEETPEVVALQNYINDCREMRIFAIKDEIKNVL 955
            ..:.:|:..::.:.     :|||:.|:...    .|.:.|....|:.        ::|.:||...
Human  1137 SNMTEFHSQISKSR-----QELEQHSVDTA----STSDAVTFITYVQ--------SLKRKIKQFE 1184

  Fly   956 KRVVFLLTHTYLSSDELHLNSRTFILP----------GELEEVLDLSAARLAVVRD---NLELAL 1007
            |:|     ..|.:...| |..:.|..|          ||.....|:...:.:.::.   ||::.:
Human  1185 KQV-----ELYRNGQRL-LEKQRFQFPPSWLYIDNIEGEWGAFNDIMRRKDSAIQQQVANLQMKI 1243

  Fly  1008 -RERRMEFEKLLAQEKRTMD-------------GFRIREIRDVLTLEELKERVDTVDLLFTTIEN 1058
             :|.|       |.|.||.|             ..|..|....||:.|.|         |..:::
Human  1244 VQEDR-------AVESRTTDLLTDWEKTKPVTGNLRPEEALQALTIYEGK---------FGRLKD 1292

  Fly  1059 LSREAKAINTEETLLQIDVSAFPLLAE----IIEKMEPIEKLWKTSYEFEKDYLIWMFERFECLN 1119
             .|| |....:|.|...|........|    .:|:::.::.:|.   |..|   :|.       .
Human  1293 -DRE-KCAKAKEALELTDTGLLSGSEERVQVALEELQDLKGVWS---ELSK---VWE-------Q 1342

  Fly  1120 ADGVREQV----------ENMHKIMYKLS------RQLAYNPVAKRAAEQMRMKIEKFRVYLPVL 1168
            .|.::||.          :|:..::.:|.      ||.|.....:|..:.. |||....:.|.
Human  1343 IDQMKEQPWVSVQPRKLRQNLDALLNQLKSFPARLRQYASYEFVQRLLKGY-MKINMLVIELK-- 1404

  Fly  1169 DSICRHGLEKRHWDQISKILGRKVN---PKLFPTLKDMIDVDIMSILPQLEEIANAAGKEYDLNN 1230
                ...|:.|||.|:.|.|  .||   .:|  ||..:.|||:......::::...|..|..|..
Human  1405 ----SEALKDRHWKQLMKRL--HVNWVVSEL--TLGQIWDVDLQKNEAIVKDVLLVAQGEMALEE 1461

  Fly  1231 GLRIMQADWRDVMFEVLQYRDSDTHILASLDDIQTLLDDHIMRTQAMKRSPFITALGSKADDWEA 1295
            .|:.::..|.....:::.|::. ..::...||:...:.:||....|||.||:.......|..||.
Human  1462 FLKQIREVWNTYELDLVNYQNK-CRLIRGWDDLFNKVKEHINSVSAMKLSPYYKVFEEDALSWED 1525

  Fly  1296 RLLLIQNIIDAWTQVQITWMYLEPIFS-SEDIMRQMPLEGRNFKAVDKLWRKIMKHTLKDRHVMA 1359
            :|..|..:.|.|..||..|:|||.||: |.||...:|:|.:.|:::...:..:||...|...||.
Human  1526 KLNRIMALFDVWIDVQRRWVYLEGIFTGSADIKHLLPVETQRFQSISTEFLALMKKVSKSPLVMD 1590

  Fly  1360 ATEYPEMLEVFTKAIEDLETVTKGLNTYLEQKRLFFARFFFLSNDELLEILSETKDPMRVQPHLR 1424
            ......:.....:..:.|..:.|.|..|||::|..|.||:|:.:::||||:..:|:..::|.|.:
Human  1591 VLNIQGVQRSLERLADLLGKIQKALGEYLERERSSFPRFYFVGDEDLLEIIGNSKNVAKLQKHFK 1655

  Fly  1425 KCFEGIGSLTFDDNMEIVEMVSDEEERVALVR---------KINPQLANGLVEMWLKEVEMVMLD 1480
            |.|.|:.|:..:::..:|..:|..|....:.:         |||..|.  |||   ||:.:.:..
Human  1656 KMFAGVSSIILNEDNSVVLGISSREGEEVMFKTPVSITEHPKINEWLT--LVE---KEMRVTLAK 1715

  Fly  1481 SVKEQMREAWEDYAMVER------ISWVVSWPGQVVQGISCMAWTYEVEEAIET-----KELPAY 1534
            .:.|.:.|. |.:.....      |:|:..:..|:|...:.:||:..||.|:.:     ...|.:
Human  1716 LLAESVTEV-EIFGKATSIDPNTYITWIDKYQAQLVVLSAQIAWSENVETALSSMGGGGDAAPLH 1779

  Fly  1535 LEKSNLQI-----ADLVQLVRTDLQAGVRIAVEALIVLDVHDRDVVKYLTDCRITNIQDFDWISQ 1594
            ...||:::     ||.|.:.:..|:   |..:|.||...||.|||.:.|...:|.|.:.|:|:||
Human  1780 SVLSNVEVTLNVLADSVLMEQPPLR---RRKLEHLITELVHQRDVTRSLIKSKIDNAKSFEWLSQ 1841

  Fly  1595 LRYYWKVNEKNED---WVCVSMVVTDVEYGMEYLGNLPRLVVTPLTDRCYRTLMGALKLCLGGAP 1656
            :|:|:  :.|..|   .:.:.|......||.||||...:||.||||||||.|:..||:..|||:|
Human  1842 MRFYF--DPKQTDVLQQLSIQMANAKFNYGFEYLGVQDKLVQTPLTDRCYLTMTQALEARLGGSP 1904

  Fly  1657 EGPAGTGKTETCKDLAKAVAKKCVVFNCSDGLDYKALGKFFKGLAQSGAWACFDEFNRIELEVLS 1721
            .|||||||||:.|.|...:.:..:||||.:..|::|:|:.|.||.|.|||.|||||||:|..:||
Human  1905 FGPAGTGKTESVKALGHQLGRFVLVFNCDETFDFQAMGRIFVGLCQVGAWGCFDEFNRLEERMLS 1969

  Fly  1722 VVAQQILTIQRAIGRKVVKFFFEDT-----------MLKLDPTCSIFITMNPGYAGRTELPDNLK 1775
            .|:||:..||.|: |:.....::.|           .:|:.|..:||||||||||||:.||||||
Human  1970 AVSQQVQCIQEAL-REHSNPNYDKTSAPITCELLNKQVKVSPDMAIFITMNPGYAGRSNLPDNLK 2033

  Fly  1776 VLFRTVAMMVPDYAMIGEITLYSNGFDMARNLSQKIVQAYKLCSEQLSSQSHYDYGMRAVKSVLL 1840
            .|||::||..||..:|.::.|||.||..|..|:.|||..:|||.||||||||||:|:||:||||:
Human  2034 KLFRSLAMTKPDRQLIAQVMLYSQGFRTAEVLANKIVPFFKLCDEQLSSQSHYDFGLRALKSVLV 2098

  Fly  1841 ASASLRR---------------------LYVDLPEPEIVLRAIVDVNLPKFLEQDISLFIGIYMD 1884
            ::.:::|                     :..:|||.||:::::.:..:||.:.:||.|...:..|
Human  2099 SAGNVKRERIQKIKREKEERGEAVDEGEIAENLPEQEILIQSVCETMVPKLVAEDIPLLFSLLSD 2163

  Fly  1885 LFPGVELPMPQRGD----------ILKWLHINLADRNLQATPWYLEKILQIYEMLLVRHGLMIVG 1939
            :||||:.   .||:          :.:.:::...|.......| :||:||:|::..:.||||:||
Human  2164 VFPGVQY---HRGEMTALREELKKVCQEMYLTYGDGEEVGGMW-VEKVLQLYQITQINHGLMMVG 2224

  Fly  1940 GSMGGKTTAYQVLAQTLRNVSTDEEATLKEFPVTFRIINPKAITMGQLYGRFDPVSHEWYDGVLA 2004
            .|..||:.|::||.:.|..:...|...        .||:||||:...|||..||.:.||.||:..
Human  2225 PSGSGKSMAWRVLLKALERLEGVEGVA--------HIIDPKAISKDHLYGTLDPNTREWTDGLFT 2281

  Fly  2005 KTFREQVQGPKGE---RAWVMFDGPVDAVWIENLNTVLDDNKKLCLMSGEIMQMTKLMNMMFEPA 2066
            ...|:.:...:||   |.|::|||.||..|:||||:||||||.|.|.:||.:.:...:.:|||..
Human  2282 HVLRKIIDSVRGELQKRQWIVFDGDVDPEWVENLNSVLDDNKLLTLPNGERLSLPPNVRIMFEVQ 2346

  Fly  2067 DLEQASPATVSRCGMIYMEPSQLGWRALHKSFINVLVNKVGLGDIYMTLFED------------- 2118
            ||:.|:.||||||||::.....|....:..:|:      ..|..|.:...||
Human  2347 DLKYATLATVSRCGMVWFSEDVLSTDMIFNNFL------ARLRSIPLDEGEDEAQRRRKGKEDEG 2405

  Fly  2119 ----------------------MTEWLVPAALEFLPQCKQMLELSPIYQYQTFSRFF--LH---- 2155
                                  .:..||..|||...|.:.:::|:   :.:.....|  ||
Human  2406 EEAASPMLQIQRDAATIMQPYFTSNGLVTKALEHAFQLEHIMDLT---RLRCLGSLFSMLHQACR 2467

  Fly  2156 ----FLEKHKQFN------QAWFQQMFLFCFAWAYCSALTGQGQKTFDALLRKVIYGSNENFPKP 2210
                :...|..|.      :.:.|:..::...|    :|:|..:....|.|.:.|.... ..|.|
Human  2468 NVAQYNANHPDFPMQIEQLERYIQRYLVYAILW----SLSGDSRLKMRAELGEYIRRIT-TVPLP 2527

  Fly  2211 KYFSLNRGQMFPEKLLFLDYRFDEAENWWTWQKSDDSASTTSNFPENAQISELIVPTKET----G 2271
            .          ...:..:||....:..|..||.........::   .....:::|||.:|    .
Human  2528 T----------APNIPIIDYEVSISGEWSPWQAKVPQIEVETH---KVAAPDVVVPTLDTVRHEA 2579

  Fly  2272 YISYWQEFCISKSYAMLVVGPTGTGKSAIITSNLLAMPKFANLVNVINFSARTSAQMVQDTIMSK 2336
            .:..|    :::...:::.||.|:||:..:.|.|.|:|...  |..:|||:.|:.:::..|....
Human  2580 LLYTW----LAEHKPLVLCGPPGSGKTMTLFSALRALPDME--VVGLNFSSATTPELLLKTFDHY 2638

  Fly  2337 LDRRRKG---VFGP-SLGKKCTVFCDDVAMPSKDTYGSQAPLELLRTWLDHGYWSDLVDTT--KI 2395
            .:.||..   |..| .|||...:|||::.:|..|.||:|..:..:|..::||.:....|.|  |:
Human  2639 CEYRRTPNGVVLAPVQLGKWLVLFCDEINLPDMDKYGTQRVISFIRQMVEHGGFYRTSDQTWVKL 2703

  Fly  2396 ELVDMTLMCAMGTLGGSNFIFPRLYRHMFVVAVDSFEDSTIVRIFTTIGDWHFSKGYPEKVALL- 2459
            |.:.....|...|..|...:..|..||:.||.||....:::.:|:.|     |::.....:..|
Human  2704 ERIQFVGACNPPTDPGRKPLSHRFLRHVPVVYVDYPGPASLTQIYGT-----FNRAMLRLIPSLR 2763

  Fly  2460 --SRGLSEAMVSVYRDAIRSFLPTPAKSHYSFSLRDITRVFQGI--VMVPPKRMPDPEKLGRLWA 2520
              :..|:.|||..|..:...| ....:.||.:|.|::||..:||  .:.|.:.:| .|.|.|:||
Human  2764 TYAEPLTAAMVEFYTMSQERF-TQDTQPHYIYSPREMTRWVRGIFEALRPLETLP-VEGLIRIWA 2826

  Fly  2521 HETYRVFYDRLVDQQDRDRLLVMAVD--ACKSNLRFPLEQAFGERIEPGEKLTDNDLRNLFYGNY 2583
            ||..|:|.||||:.::| |.....:|  |.|.......|:|..              |.:.|.|:
Human  2827 HEALRLFQDRLVEDEER-RWTDENIDTVALKHFPNIDREKAMS--------------RPILYSNW 2876

  Fly  2584 MEPDAEPKFYDEGDTYEKLEKLMKYYLREYNSFSSTPMDLVMFRFAIEHVSRVSRVLQMPRGNIL 2648
            :..|..|...:|...|.| .:|..:|..|.:      :.||:|...::||.|:.|:.:.|:|::|
Human  2877 LSKDYIPVDQEELRDYVK-ARLKVFYEEELD------VPLVLFNEVLDHVLRIDRIFRQPQGHLL 2934

  Fly  2649 MVGMGGSGRRSSARLAAYIADCRLMTVQVSKSYTITDWRDDLKKILMSASFNLNHTVFLFSDAQA 2713
            ::|:.|:|:.:.:|..|::....:..::|.:.||..|:.:||:.:|..:........|:..::..
Human  2935 LIGVSGAGKTTLSRFVAWMNGLSVYQIKVHRKYTGEDFDEDLRTVLRRSGCKNEKIAFIMDESNV 2999

  Fly  2714 TDEGYVEDINGILNTGDLPNLYQLEDKATIMENMANVAKQLGKILDTLPSEVYAYYIDRIREQLH 2778
            .|.|::|.:|.:|..|::|.|::.::.||:|......|::.|.:||: ..|:|.::..::...||
Human  3000 LDSGFLERMNTLLANGEVPGLFEGDEYATLMTQCKEGAQKEGLMLDS-HEELYKWFTSQVIRNLH 3063

  Fly  2779 IALAFSPIGDSFKERIRVYPSLINCCTIDWYMPWPEEALSRVGVYFVSSMNLNRPH--GEETQEP 2841
            :....:|..:..|:|....|:|.|.|.::|:..|..|||.:||..|.|.|:|.:|:  ..:....
Human  3064 VVFTMNPSSEGLKDRAATSPALFNRCVLNWFGDWSTEALYQVGKEFTSKMDLEKPNYIVPDYMPV 3128

  Fly  2842 VQSKDAADPDEEEVRRETVGVEREQTQLEADLVDCVMYFHQSVVDASEKCYLELNRRNYVTPSAY 2906
            |..|....|...|.                 :|:..::.||::..|:.:......|...:||..|
Human  3129 VYDKLPQPPSHREA-----------------IVNSCVFVHQTLHQANARLAKRGGRTMAITPRHY 3176

  Fly  2907 LELLKAFRTFYTRKLDEITRLRDRYTTGLEKLDFAAGQVGEMQTNLYDLQPKLKVLSEETDRIMV 2971
            |:.:..:...:..|..|:...:.....||.|:.....||.|::.:|.....:|:|.:...:..:.
Human  3177 LDFINHYANLFHEKRSELEEQQMHLNVGLRKIKETVDQVEELRRDLRIKSQELEVKNAAANDKLK 3241

  Fly  2972 NIERETAEAEKKK--------------EVVGADEAAANEAAAAAQAIKDDCETDLAEAIPAMEAA 3022
            .:.::..||||||              ||:...:.:..|              ||.:..||:..|
Human  3242 KMVKDQQEAEKKKVMSQEIQEQLHKQQEVIADKQMSVKE--------------DLDKVEPAVIEA 3292

  Fly  3023 LEALNTLKPADIFIVKSMKNPPYGVKLTMEAVCVIRGIKPDRKPDPSGHMVEDYWGPSMRMLSDM 3087
            ..|:.::|...:..|:||.|||..|||.:|::|::.|   :...|         |.....::...
Human  3293 QNAVKSIKKQHLVEVRSMANPPAAVKLALESICLLLG---ESTTD---------WKQIRSIIMRE 3345

  Fly  3088 KFLDSLKTFDKDNIPPPIIKRIREKYIADRDFVPEKIKAASMACEGICRWVRAMDVYDKVARIVM 3152
            .|:.::..|..:.|...|.:::::.|:::..:..|.:..||:||..:.:|..|...|..:.:.|.
Human  3346 NFIPTIVNFSAEEISDAIREKMKKNYMSNPSYNYEIVNRASLACGPMVKWAIAQLNYADMLKRVE 3410

  Fly  3153 PKKAALAEAEGELSQQMEKLNAKRAELQVILDKLQKLNDFFAEKSREKKRLEDEIDNCEKKLNRA 3217
            |.:..|.:.|.:.....:|.|.....::.:...:.:..:.:|....|.:.::.::...|.|:||:
Human  3411 PLRNELQKLEDDAKDNQQKANEVEQMIRDLEASIARYKEEYAVLISEAQAIKADLAAVEAKVNRS 3475

  Fly  3218 EKLLGGLGGEKTRWSEAAKNLHESISNIVGDVLLAGGCTAYLGYFTTEYRVNILDDWNALCKRKH 3282
            ..||..|..|:.||.:.::.....:|.|.||.||:....||.|||..:.|.|:...|:...::.:
Human  3476 TALLKSLSAERERWEKTSETFKNQMSTIAGDCLLSAAFIAYAGYFDQQMRQNLFTTWSHHLQQAN 3540

  Fly  3283 IPSSETFSLATTLGHPMTIRAWSLAGLPADNFSVENGIIVTNSSRYSLLIDPQVQANKWIKNMEK 3347
            |......:....|.:......|..:.||||:...||.|::...:||.|:|||..||.::|.|..|
Human  3541 IQFRTDIARTEYLSNADERLRWQASSLPADDLCTENAIMLKRFNRYPLIIDPSGQATEFIMNEYK 3605

  Fly  3348 NNNLKVIKQSDANYMQVLELAITFGQPVLIENVGEKLDSNLTPILEKNVIKHKGGLFIKSGDQMI 3412
            :..:......|..:.:.||.|:.||.|:|:::| |..|..|.|:|.:.|.:..|.:.|..|||.|
Human  3606 DRKITRTSFLDDAFRKNLESALRFGNPLLVQDV-ESYDPVLNPVLNREVRRTGGRVLITLGDQDI 3669

  Fly  3413 EYNPNFRLYITTCLRNP--RYPPEVMVMVTVLNFMITEQGLREQLLAIVVAHERPDLQEKKEQLI 3475
            :.:|:|.::::|  |:|  .:||::...||.:||.:|...|:.|.|..|:..||||:.||:..|:
Human  3670 DLSPSFVIFLST--RDPTVEFPPDLCSRVTFVNFTVTRSSLQSQCLNEVLKAERPDVDEKRSDLL 3732

  Fly  3476 IESARNRDALYTIESKILEVLSTSEGNVLEDENAINILSSSKILSEDIQEKQVIAVATEI---EI 3537
            ......:..|..:|..:|:.|:..:|.:|:|:..|..|.:.|..:.::..|   ...|:|   |:
Human  3733 KLQGEFQLRLRQLEKSLLQALNEVKGRILDDDTIITTLENLKREAAEVTRK---VEETDIVMQEV 3794

  Fly  3538 DAARQQYIPVSKHSAILFFCISELANVDPMYQYSLSWFLNLFVNTILKAPKSDQLSERLKNLNDY 3602
            :...|||:|:|...:.::|.:..|..:..:|||||.:||:::.|.:.:.|....:::..:.|: .
Human  3795 ETVSQQYLPLSTACSSIYFTMESLKQIHFLYQYSLQFFLDIYHNVLYENPNLKGVTDHTQRLS-I 3858

  Fly  3603 FTKSI----YTNVCRSLFEKDKLVISLVMCLGILVSQGRVEK----AALLFFLTGGIGYKTIPPN 3659
            .||.:    :..|.|.:..:|.  |:..|.|..:..:|.|.:    |....||.|.....:....
Human  3859 ITKDLFQVAFNRVARGMLHQDH--ITFAMLLARIKLKGTVGEPTYDAEFQHFLRGNEIVLSAGST 3921

  Fly  3660 PLGAWLPDKSWASVCKAADLEGLKNLPQMMETYSDEWHNFY-DASNPDQLQLP------APHNTV 3717
            |....|..:...:|.:.:.|...|:|  :.:..:||....: |:|:|:| .:|      .|...:
Human  3922 PRIQGLTVEQAEAVVRLSCLPAFKDL--IAKVQADEQFGIWLDSSSPEQ-TVPYLWSEETPATPI 3983

  Fly  3718 ND-MYFLIVIKSLRPDKLVPAVRAFITRNLDRSF--VEPPPFDLAASF-ADSSPKIPLVFLLSAG 3778
            .. ::.|::|::.|||:|:.....|::.||..||  :...|.||.... .:..|..|::.....|
Human  3984 GQAIHRLLLIQAFRPDRLLAMAHMFVSTNLGESFMSIMEQPLDLTHIVGTEVKPNTPVLMCSVPG 4048

  Fly  3779 SDPMASLFMFAKQRNMYDKLKTISLGQGQG-PRAEKMIMEAARHGQWVVLQNCHVAISWMGDLER 3842
            .|....:...|.::|  .::.:|::|..:| .:|:|.|..|.:.|:||:|:|.|:|..|:..||:
Human  4049 YDASGHVEDLAAEQN--TQITSIAIGSAEGFNQADKAINTAVKSGRWVMLKNVHLAPGWLMQLEK 4111

  Fly  3843 --------ICNDTTLTDGANHDYRLWCTSYPSAVFPVSVLQNSVKMTNEPPKGLRANMHRSFTSD 3899
                    .|            :||:.|...:...||::|:.......|||.|::|||.|:|:|.
Human  4112 KLHSLQPHAC------------FRLFLTMEINPKVPVNLLRAGRIFVFEPPPGVKANMLRTFSSI 4164

  Fly  3900 PLMRDKFFTNAFLFSDSANKCWLRGVFALVFFHAVVQERREFGPLGWNIPYEFNESDLKISLLQL 3964
            |:.|         ...|.|: ..|..|.|.:|||::|||..:.||||:..|||.||||:.:...:
Human  4165 PVSR---------ICKSPNE-RARLYFLLAWFHAIIQERLRYAPLGWSKKYEFGESDLRSACDTV 4219

  Fly  3965 KMFINQS---------QSIPFRGHVYLTGECNYGGRVTDDKDRRLILSLLNMIYNPNTIE-EDNY 4019
            ..:::.:         ..||:.....|..:..|||||.::.|:||:.:.|..::...:.: |...
Human  4220 DTWLDDTAKGRQNISPDKIPWSALKTLMAQSIYGGRVDNEFDQRLLNTFLERLFTTRSFDSEFKL 4284

  Fly  4020 ALSQSG--TYRVPLSPTRLNSIEYVSSFPLSPHPEVYGLHENADINRNVKETNALISGVLLTQ-- 4080
            |....|  ..::|....|...:::|...|.:..|...||..||:             .||||.
Human  4285 ACKVDGHKDIQMPDGIRREEFVQWVELLPDTQTPSWLGLPNNAE-------------RVLLTTQG 4336

  Fly  4081 TDLMASVKASSSGGAKEDPAIAICKQVLKQLPEEFNIDEVSKTYP----VIYTNSMN-------- 4133
            .|:::.:........::|.|.|       :..::...|..|...|    .::|.:.|
Human  4337 VDMISKMLKMQMLEDEDDLAYA-------ETEKKTRTDSTSDGRPAWMRTLHTTASNWLHLIPQT 4394

  Fly  4134 ------TV--LRQELIRF--------NRLLSYIRKSLVNVGKAVVGQIAMIPELERTHASMVIGK 4182
                  ||  ::..|.||        .:||..:|:.|.:|.:...|:......|......:|.|.
Human  4395 LSHLKRTVENIKDPLFRFFEREVKMGAKLLQDVRQDLADVVQVCEGKKKQTNYLRTLINELVKGI 4459

  Fly  4183 LPADWLKKSYPSLKPLGSYVSDLLARLAFFQ-----------EWIDNGEPMVYWISGFYFTQSFI 4236
            ||..|...:.|:...:..:|||...|:...|           :.:.|   :...:.|.:..:::|
Human  4460 LPRSWSHYTVPAGMTVIQWVSDFSERIKQLQNISLAAASGGAKELKN---IHVCLGGLFVPEAYI 4521

  Fly  4237 TGVLQNYSRKNRFQIDMILIEFAVTKFEVQVPGTPDIGAY-IRGIFIEGARWNRKTKEVDESFSK 4300
            |...|..::.|.:.::.:.:|..||..:   ..|.|..:: :.|:.::||..|....    |.|.
Human  4522 TATRQYVAQANSWSLEELCLEVNVTTSQ---GATLDACSFGVTGLKLQGATCNNNKL----SLSN 4579

  Fly  4301 VLFDTLPVIYLRPVLKALEDLPRSTAGGEPETIYDCPVYKTSERRGVLSTTGHSTNFVMYLQLRC 4365
            .:...||:..||.|        :.|...:..::...|||....|..::        |.:..::..
Human  4580 AISTALPLTQLRWV--------KQTNTEKKASVVTLPVYLNFTRADLI--------FTVDFEIAT 4628

  Fly  4366 SRKPMHWINRGTACLC 4381
            ...|..:..||.|.||
Human  4629 KEDPRSFYERGVAVLC 4644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dnah3	NP_647937.2	DHC_N2	1086..1489	CDD:285579	109/431 (25%)
		P-loop_NTPase	1620..1847	CDD:304359	124/237 (52%)
		P-loop_NTPase	1934..2079	CDD:304359	63/147 (43%)
		P-loop_NTPase	2264..2522	CDD:304359	77/272 (28%)
		P-loop_NTPase	2613..2916	CDD:304359	74/304 (24%)
		MT	2929..3272	CDD:289543	83/356 (23%)
		AAA_9	3304..3519	CDD:289547	73/216 (34%)
		Dynein_heavy	3659..4373	CDD:281078	181/787 (23%)
DYNC1H1	NP_001367.2	Stem. /evidence=ECO:0000250	53..1867		387/1911 (20%)
		DHC_N1	242..832	CDD:400611	114/680 (17%)
		Interaction with DYNC1I2. /evidence=ECO:0000250	448..703		54/318 (17%)
		Interaction with DYNC1LI2. /evidence=ECO:0000250	651..802		28/169 (17%)
		DYN1	1046..4329	CDD:227570	955/3553 (27%)
		AAA 1. /evidence=ECO:0000250	1868..2099		124/231 (54%)
		AAA 2. /evidence=ECO:0000250	2180..2452		88/289 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2390..2411		2/20 (10%)
		AAA 3. /evidence=ECO:0000250	2556..2805		68/263 (26%)
		AAA 4. /evidence=ECO:0000250	2899..3168		71/292 (24%)
		Stalk. /evidence=ECO:0000250	3189..3500		72/336 (21%)
		AAA 5. /evidence=ECO:0000250	3553..3782		74/231 (32%)
		AAA 6. /evidence=ECO:0000250	4005..4221		72/239 (30%)
		Dynein_C	4333..4644	CDD:408026	65/343 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5245
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100025
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.710