DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32237 and Fscb

DIOPT Version :9

Sequence 1:	NP_729037.1	Gene:	CG32237 / 38584	FlyBaseID:	FBgn0052237	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_001156743.1	Gene:	Fscb / 623046	MGIID:	3646964	Length:	1062	Species:	Mus musculus

Alignment Length:	972	Identity:	217/972 - (22%)
Similarity:	318/972 - (32%)	Gaps:	379/972 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 IPVEQARHRRDVS----------EIVNEYIPPAEEVGAELAQDPAAL-------------GDDGY 59
            ||::......:.|          ::|:...|||:::.:  .:.||.:             .|..|
Mouse   269 IPIQAPSPAEETSAAETATTTAKDVVDIQAPPADKLSS--VEAPADISPTLVQGALSDKPSDQQY 331

  Fly    60 RYKTVRRLKLRQRRDVSEIANEYLPPTEEVVADAPVEEVPVEEASQDSAVLAADGYQYKTVRRLK 124
            ...|..........|:...:.|.|...:.:..|:.:|::.:.|
Mouse   332 PQGTEMAPSELPVEDLDPFSEEVLEKVQALTTDSMLEDLGIAE---------------------- 374

  Fly   125 YRQRRDVSDIANE-----YLPPTEEVVADAPVE-EVPVEEASQDSAVLAADGYKYKTVRRLKYRQ 183
                   |.||.|     ..|.:||...:.|.| ..|:....::||:|..:  |:.|
Mouse   375 -------STIAEETSGKVQHPLSEETSKEVPAEVHFPIAADFEESAILINE--KFAT-------- 422

  Fly   184 RRDVSEIANEYLPP-TEEVVADTPVEEV---PVEEASQD---SAVLAADGYKYKTVRRLKYRQRR 241
                .|:..||.|| .|||.||....||   ..|:||::   |.||...            .::.
Mouse   423 ----DEVFEEYKPPIIEEVSADKATAEVQPPSAEDASEEVAPSEVLPPS------------TEQG 471

  Fly   242 DVSEIANEYL-PPTEDAATEA---PIEEAPV-------EEASQDSAVLAADGYQYKTVRRLKYRQ 295
            .|.::..|.| .|||:..||.   |.||.|.       ||...:.....|:
Mouse   472 TVEDLTAEVLSTPTEEGPTEVPPQPTEEGPAEVPPPLSEEGPAEVPPAPAE-------------- 522

  Fly   296 RRDVSEIANEYL-PPTEEVVADAP---VEEVPVEEASQDSAVLAADGYKYKTVRRLKYRQRRDVS 356
                 |...|.| ||.||..|:.|   .||.|.|
Mouse   523 -----EAPAEVLPPPAEEAPAEVPPPLTEEGPAE------------------------------- 551

  Fly   357 EIANEYLPP--TEEVVAD---APVEEVPVEEASQDSAVLAADGYQYKTVRRLKYRQRRDVSEIAN 416
                  :||  |||..|:   ||.||||.|       ||.
Mouse   552 ------VPPTLTEEGPAEVPLAPAEEVPAE-------VLP------------------------- 578

  Fly   417 EYLPPTEEVVADAP---VEEVP-------VEEASQDSAVLAADGYKYKTVRRLKYRQRRDVSEIA 471
               ||.|||.|:.|   .||.|       .||..::...|.|:....|.......:...:||.
Mouse   579 ---PPAEEVPAEVPPPLTEEGPAEVPPPLTEEGPEEVPPLPAEEAPTKVPPSPAEKGSAEVSP-- 638

  Fly   472 NEYLPPTEEVVADA---PVEEVPVEEASQDSAVLAADGYQYKTVRRLKYRQRRDVSEIANEYLPP 533
                |.|||..|:.   |.||.|.|..|..    |.:|                .||:.   |||
Mouse   639 ----PQTEEGPAEVPPPPAEEFPTEVPSSS----AEEG----------------SSEVP---LPP 676

  Fly   534 TEDAATEAP---IEEAPVE---EASQDSAV-----LAADGYQYKTVRRLKYRQRRDVSEIANEYL 587
            |.:...|||   .||||||   .|::::.|     .|.:|                   :|....
Mouse   677 TAERPEEAPPPATEEAPVEVLPPATEEAPVEVQSPAAEEG-------------------LAEVPP 722

  Fly   588 PPTEEVVADAPVEEVPVE----EASQD-SAVLAADGYKYKTVRRLKYRQRRDVSEIANEYLPPTE 647
            |||||    :|..:||.|    :|.:. ..||...|             .....|.:.:..||:.
Mouse   723 PPTEE----SPTHDVPTEVQVPQAKESPGQVLPLSG-------------ESTAEEASAQVQPPSF 770

  Fly   648 DAATEAPIEEAPVEEASQDSAVLAADGYQYKTVRRLKYRQRRDVSEIANEYLP------PTEEVV 706
            :   :||:|..|:||                            |.:|..:.||      |||::.
Mouse   771 E---KAPLESLPLEE----------------------------VEKIHLDNLPFEVQPLPTEDIA 804

  Fly   707 ADAPVEE--VPVEE--ASQDSAVLAADGYKYKTVRRLKYRQRRDVSEIANEYLPPTEDAATEAPI 767
            ...|.|.  :|.:|  |.:|:.......::...:...........||...    ..||:|.. |.
Mouse   805 IGVPAESQALPADENPAREDTVETQPSSFEGAPIAENPIEAPLPASEADT----GREDSAVH-PS 864

  Fly   768 EEAPVEEASQDSAVLAADGYQYKTVRRLKYRQRRDVSEIANEYLPPSE---EVVTEA-------- 821
            ..||.:||..:..:|..|...            .::|.:.|:.||..|   |||:|.
Mouse   865 SLAPTDEAPAEIQILQTDDIP------------TEMSPVENQPLPAEEGFPEVVSEEEATAAEVR 917

  Fly   822 -PLEE-APVEEASQDSAVLAADGYQYKTVRRLKYRQRRDVSEIASDYLPPAEETVVADAPVE 881
             ||.| ||.:||:.::        |..:|.....|...||..::.:  .|.||:...|.|::
Mouse   918 FPLSEGAPAQEATVEA--------QLTSVEESPKRASVDVQPLSPE--TPVEESPGVDLPLK 969

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32237	NP_729037.1	GYR	56..73	CDD:128953	3/16 (19%)
		GYR	168..185	CDD:128953	2/16 (13%)
		GYR	224..241	CDD:128953	0/16 (0%)
		GYR	336..353	CDD:128953	0/16 (0%)
		GYR	448..465	CDD:128953	2/16 (13%)
		GYR	616..633	CDD:128953	1/16 (6%)
		GYR	728..745	CDD:128953	0/16 (0%)
		GYR	892..909	CDD:128953
Fscb	NP_001156743.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..73
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	272..294		1/21 (5%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	317..343		3/25 (12%)
		PHA03247	<434..887	CDD:223021	153/668 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	806..970		44/191 (23%)
		rne	<828..997	CDD:236766	38/169 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1014..1042
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR36135
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100