DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32237 and Fscb

DIOPT Version :9

Sequence 1:	NP_729037.1	Gene:	CG32237 / 38584	FlyBaseID:	FBgn0052237	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_001258036.1	Gene:	Fscb / 500659	RGDID:	1561721	Length:	812	Species:	Rattus norvegicus

Alignment Length:	975	Identity:	190/975 - (19%)
Similarity:	317/975 - (32%)	Gaps:	386/975 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 QDPAALGDDGYRYKTVRRLKLRQRRDVSEIANE------YLPPTEEVVADAPVEEVPVEEAS--- 104
            :.|.:||...||.:.:....:..:...:||..:      ..||..:  |...:..:|..:|:
  Rat     8 EQPISLGRQEYRRRRLPSQPMVDKSQQTEIGEKKKGMAAVQPPAPK--ATHSIGNIPGGKANYSG 70

  Fly   105 --QDSAVLAADGYQYKTVRRLKYRQRRDVSD---------------------------IANEYLP 140
              .:|.:|::...|    ..:|.:|.::::|                           ...|..|
  Rat    71 KEYESLILSSQLQQ----TWMKRKQGQEMTDKSFQTDTSVEEKVEVIFMDKALEENSASVGEIAP 131

  Fly   141 PTEEVVADA--PVEEVP---VEEASQDS--------AVLAADGYKYKTVRRLKYRQRRDVSEIAN 192
            .:.:.|::.  |....|   ::.|.|.|        ::.:.|                .|.:...
  Rat   132 ASPQGVSEVEIPTSRPPSLLIDRAQQTSCTGDWSLISICSKD----------------KVDKEQQ 180

  Fly   193 EYLPPTEEVVADTP--------VEEVPVEEASQDSAVLAADGYKYKTVRRLKYRQRRDVSEIANE 249
            .|....|..|...|        .|.||:.|   |.:::..||             ..::..::.|
  Rat   181 TYFSELETTVKSMPGSSLIKSKEETVPIAE---DGSLVEIDG-------------SLEIEVLSTE 229

  Fly   250 YLPPTEDAATE---------APIEEAPV-------EEASQDSAVLAADGYQYKTVRRLKYRQRRD 298
            .:|....:.||         .|.:||.|       ||.|..:..||.:....:|..:.. ::..|
  Rat   230 KIPDVVMSFTEGEISGELQAVPDDEATVKAEHFFTEETSIQAPSLAKETSAAETTAKTP-KEFVD 293

  Fly   299 VSEIANEYLPPTE--------------------------EVVA--DAPVEE-VPV-EEASQDSAV 333
            :..:..:.|..||                          .|||  :.|||: ||: ||..:....
  Rat   294 IQALPADELSSTEPPADIRPPLVKGTLSEEPSDQQYPKGTVVAPSELPVEDLVPLSEEVLEKVQA 358

  Fly   334 LAADGYKYKTVRRLKYRQRRDVSEIANEYLPP-TEEVVADAPVE-EVPVEEASQDSAVLAADGYQ 396
            ||.|.....:.|    .:...|.|...|..|| :||:..:.|.| .:|:...|::..::....:
  Rat   359 LAIDTILDDSGR----AESTTVEEATGEVQPPLSEEITKEVPAEVHLPIATHSKEIVIIIDKEF- 418

  Fly   397 YKTVRRLKYRQRRDVSEIAN-----EYLPPTEEVVADAPVEEVPVEEASQDSAVLAADGYKYKTV 456
              .:......|...::|:|.     |..||:.|   |||.|..|.|.....:
  Rat   419 --AIDEDFEDQPPFITEVAEDEATAEVQPPSAE---DAPEEVAPSEVLPPPT------------- 465

  Fly   457 RRLKYRQRRDVSEIANEYLPPTEEV----VADAPVEEVPVEEASQDSAVLAADGYQYKTVRRLKY 517
                  ::..|..:..|.|.|:.||    |...|.||.|:...:::|..
  Rat   466 ------EQGTVEHMTAEVLSPSTEVGPAEVPPLPTEEWPLPPVTEESPA---------------- 508

  Fly   518 RQRRDVSEIANEYLPPTEDAATEAPIEEAPVEEASQDSAVLAADGYQYKTVRRLKYRQRRDVSEI 582
                       |..||..:   |.|||  |.||..:|..:|..:                   ||
  Rat   509 -----------EVTPPETE---EGPIE--PAEEGPEDGLLLPTE-------------------EI 538

  Fly   583 ANEYLPPT------EEVV----ADAPVEEVPVEE---ASQDSAVLAADGYKYKTVRRLKYRQRRD 634
            .:|..||:      ||||    .:.|::::|:|.   .:::.|....|.::...|
  Rat   539 PSEVQPPSLEKVPLEEVVIPQAEEVPLDDLPIEVQPLPAENIAGWVPDEFQAFPV---------- 593

  Fly   635 VSEIANEYLPPTEDAATEAP--IEEAPVEEASQDSAVLAADGYQYKTVRRLKYRQRRDVSEIANE 697
                 :|| |..||.....|  :|.||:||:|.::.:|||:.               |.:||
  Rat   594 -----DEY-PAREDTVEVQPSSLESAPIEESSVEAQLLAAEA---------------DTAEI--- 634

  Fly   698 YLPPTEEVVADAPVEEVPVEEASQDSAVLAADGYKYKTVRRLKYRQRRDVSEIANEY-----LPP 757
                          ||.|.|.|..:..:|.|:....|.             |:|..:     |||
  Rat   635 --------------EETPTEVAPAEDQLLPAEEVVLKV-------------EVATAWSPLSELPP 672

  Fly   758 TEDAATEAPIEEAPVEEASQDSAVLAADGYQYKTVRRLKYRQRRDVSEIANEYLPPSEEVVTEA- 821
            .|:|..||.:  ..|||:.:.::|                    ||..      ||.:.:..|:
  Rat   673 AEEATVEAQL--TSVEESLKRTSV--------------------DVQP------PPLDTLAEESP 709

  Fly   822 -----------PLEEAPVEEASQDSAVLAADGYQYKTVRRLKYRQRRDVSEIASDYLPPAEETVV 875
                       |:.|.|.||.:                              |.|.|||:.:|.|
  Rat   710 AVKQPLKTDVVPMPEFPGEEMT------------------------------AQDPLPPSVKTTV 744

Fly 876 875
Rat 745 744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32237	NP_729037.1	GYR	56..73	CDD:128953	2/16 (13%)
		GYR	168..185	CDD:128953	1/16 (6%)
		GYR	224..241	CDD:128953	2/16 (13%)
		GYR	336..353	CDD:128953	2/16 (13%)
		GYR	448..465	CDD:128953	0/16 (0%)
		GYR	616..633	CDD:128953	2/16 (13%)
		GYR	728..745	CDD:128953	2/16 (13%)
		GYR	892..909	CDD:128953
Fscb	NP_001258036.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..66		11/59 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	269..333		7/64 (11%)
		PTZ00449	<278..541	CDD:185628	69/343 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	367..388		6/24 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	424..547		42/195 (22%)
		rne	<461..664	CDD:236766	67/333 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	672..741		24/126 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR36135
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100