Protein Alignment CG13708 and DNAAF1

DIOPT Version :10

• Sequence 1: NP_647933.1
• Gene: CG13708 / 38582
• FlyBaseID: FBgn0035577
• Length: 1301
• Species: Drosophila melanogaster
• Sequence 2: XP_011521155.1
• Gene: DNAAF1 / 123872
• HGNCID: 30539
• Length: 772
• Species: Homo sapiens
• Alignment Length: 749
• Identity: 170/749 - (22%)
• Similarity: 252/749 - (33%)
• Gaps: 211/749 - (28%)

  Fly   414 QSCDEGSALHNSNLSLYGGCGEEEESPSVMTSISALEQLSIKNKQLSLSASYGSIFQQLVFLDLY 478
            ||.|.||..|      :....|:.|......:.|:|::|..::|.....|...:::       |:
Human    64 QSGDNGSGGH------FAHPREDREDRGPRMTKSSLQKLCKQHKLYITPALNDTLY-------LH 115

  Fly   479 DNQIERIANLDGLPSLSVLLLGKNRITDIGGLSSLKDTLRVLDLHGNKLTSLGSRINCLQQLKSL 543
            ....:||.||:....|..|.|..|.|..|..|.: :..||.|.|..|.|..: ..:..||:|.:|
Human   116 FKGFDRIENLEEYTGLRCLWLQSNGIQKIENLEA-QTELRCLFLQMNLLRKI-ENLEPLQKLDAL 178

  Fly   544 NLAGNQIRQINQQDFLGLRCLRELN---LKRNKLRRINGFQHLVALERLW---LCHNDLHRVDDM 602
            ||:.|.|:.|.     .|.||..||   :..|.|..:...|||....||.   |.||.|...:.:
Human   179 NLSNNYIKTIE-----NLSCLPVLNTLQMAHNHLETVEDIQHLQECLRLCVLDLSHNKLSDPEIL 238

  Fly   603 ASIARATRLLEVTIENNPVSLAGDCVSFLVSY-------LPLLQTLSQMPITEQVRRAALAWRQ- 659
            :.:.....|..:.:..|||      :..:.:|       |..|..|...|:..:.|..|.||.:
Human   239 SILESMPDLRVLNLMGNPV------IRQIPNYRRTVTVRLKHLTYLDDRPVFPKDRACAEAWARG 297

  Fly   660 ----HKEQAQ--------AAPGSSEAYHNIR-REEVISNARTNWEL-LRSQQTVVGRPKSRLTSE 710
                .||:.|        ....|.||...|: |.|.....|.:.|. :||.:....|...|| .|
Human   298 GYAAEKEERQQWESRERKKITDSIEALAMIKQRAEERKRQRESQERGMRSAEDNSPRVPLRL-GE 361

  Fly   711 LAKINESNEGPAGEEGEMESEESQQPKELMDELQALIKLPPIAKDLRNPHE------------ED 763
            :...::....||..||:   ||....:|...:::..:|....|||...|.:            ||
Human   362 MTSSDDGENVPASAEGK---EEPPGDRETRQKMELFVKESFEAKDELCPEKPSGEEPPVEAKRED 423

  Fly   764 GASSEASSLGPNVDSCSSCYSSDNEDGGAKNKPQTPQIDENSNKVGLTEKPPSSPVTV----ASQ 824
            |......:|.......||......|||..:.:...|          ....||..||.|    ..|
Human   424 GGPEPEGTLPAETLLLSSPVEVKGEDGDGEPEGTLP----------AEAPPPPPPVEVKGEDGDQ 478

  Fly   825 SP------EVAIVTPSAPV--------------SSSPSPPALTL-----TPPAAPG-----TPVP 859
            .|      |..:::|...|              :.:|.||.|..     ||.|...     |.:.
Human   479 EPEGTLPAETLLLSPPVKVKGEDGDREPEGTLPAEAPPPPPLGAAREEPTPQAVATEGVFVTELD 543

  Fly   860 GTTSPS-------------------------------------PSTTIIS-------------TL 874
            ||.:..                                     |...:||             :|
Human   544 GTRTEDLETIRLETKETFCIDDLPDLEDDDETGKSLEDQNMCFPKIEVISSLSDDSDPELDYTSL 608

  Fly   875 PV----PATASSNASRPTSSKQRSRHAPITQL-------GLQINQRGGAAASSKRYM-------- 920
            ||    |....||....:....::...|.|.:       .|:|.::.   ..|.|.:
Human   609 PVLENLPTDTLSNIFAVSKDTSKAARVPFTDIFKKEAKRDLEIRKQD---TKSPRPLIQELSDED 670

  Fly   921 -AGSLVRAQT--------VSSSTSNS----SSSNSAGRGKATNNGLNLVATQTKAATSGNNQSSA 972
             :|.|:...|        .||...:|    :||...|.......||.|:       |||:..:||
Human   671 PSGQLLMPPTCQRDAAPLTSSGDRDSDFLAASSPEMGFHHVDQAGLELL-------TSGDLFASA 728

  Fly   973 GAAAGTGGSTTAAPPAGAAATPNAAITVSKPSAA 1006
            ..:||     ...|...||..|...:.|::||.|
Human   729 SQSAG-----ITVPTESAATPPETCVGVAQPSQA 757

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG13708	NP_647933.1	leucine-rich repeat	449..471	CDD:275380	4/21 (19%)
		PPP1R42	467..661	CDD:455733	56/211 (27%)
		leucine-rich repeat	472..493	CDD:275380	5/20 (25%)
		leucine-rich repeat	494..516	CDD:275380	7/21 (33%)
		leucine-rich repeat	517..539	CDD:275380	7/21 (33%)
		leucine-rich repeat	540..563	CDD:275380	8/22 (36%)
		leucine-rich repeat	564..585	CDD:275380	8/23 (35%)
		leucine-rich repeat	611..637	CDD:275380	6/32 (19%)
DNAAF1	XP_011521155.1	leucine-rich repeat	111..130	CDD:275380	5/25 (20%)
		PPP1R42	112..296	CDD:455733	56/203 (28%)
		leucine-rich repeat	153..174	CDD:275380	7/21 (33%)
		leucine-rich repeat	175..196	CDD:275380	10/25 (40%)
		leucine-rich repeat	197..221	CDD:275380	7/23 (30%)
		leucine-rich repeat	222..243	CDD:275380	5/20 (25%)
		leucine-rich repeat	247..274	CDD:275380	6/32 (19%)
		PHA03169	296..>508	CDD:223003	49/225 (22%)